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Frizzled-4

Summary

UniProt ID

Q61088

Gene Symbol

Fzd4

Organism

Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0005450
PubChem: Q61088

Annotation

Keyword

Cell membrane
Developmental protein
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Signal
Transmembrane helix
Ubl conjugation
Wnt signaling pathway

Gene Ontology (GO)

Displaying entries **11 - 20** of 30 in total

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GO Term
positive regulation of dendrite morphogenesis
retina vasculature development in camera-type eye
retina vasculature morphogenesis in camera-type eye
cerebellum vasculature morphogenesis
retinal blood vessel morphogenesis
cellular response to leukemia inhibitory factor
regulation of vascular endothelial growth factor receptor signaling pathway
extracellular matrix-cell signaling
canonical Wnt signaling pathway
response to hypoxia

Displaying **all 6** entries
GO Term
plasma membrane
cell-cell junction
synapse
dendrite
glutamatergic synapse
cell surface

Displaying entries **1 - 10** of 12 in total

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GO Term
cytokine receptor activity
G protein-coupled receptor activity
cytokine binding
signaling receptor activity
protein-containing complex binding
Wnt-protein binding
PDZ domain binding
ubiquitin protein ligase binding
protein homodimerization activity
Wnt receptor activity

Annotation information from UniProt.

Sequence

MAWPGTGPSSRGAPGGVGLRLGLLLQFLLLLRPTLGFGDEEERRCDPIRIAMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLREFGFAWPDTLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEECHSVGSNSDQYIWVKRSLNCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTTFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWALFRYSADDSNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNSGKVKREKRGNGWVKPGKGNETVV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
59		22823882 23002422
144

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Asymmetric localization of PCP proteins	Mus musculus
Ca2+ pathway	Mus musculus
Cargo recognition for clathrin-mediated endocytosis	Mus musculus
Clathrin-mediated endocytosis	Mus musculus
Regulation of FZD by ubiquitination	Mus musculus
WNT5A-dependent internalization of FZD4	Mus musculus