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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Epidermal growth factor receptor
Summary
- UniProt ID
- P04412
- Gene Symbol
-
- Egfr
- DER
- c-erbB
- top
- Organism
- Drosophila melanogaster (fruit fly)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Developmental protein
- Glycoprotein
- Phosphoprotein
- Receptor
- Reference proteome
- Signal
- Transmembrane helix
- Tyrosine-protein kinase
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| apical plasma membrane |
| basal plasma membrane |
| plasma membrane |
| receptor complex |
| GO Term |
|---|
| identical protein binding |
| epidermal growth factor receptor activity |
| ATP binding |
| transmembrane receptor protein tyrosine kinase activity |
Sequence
MLLRRRNGPCPFPLLLLLLAHCICIWPASAARDRYARQNNRQRHQDIDRDRDRDRFLYRSSSAQNRQRGGANFALGLGANGVTIPTSLEDKNKNEFVKGKICIGTKSRLSVPSNKEHHYRNLRDRYTNCTYVDGNLKLTWLPNENLDLSFLDNIREVTGYILISHVDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFVTYSKMYTLEIPDLRDVLNGQVGFHNNYNLCHMRTIQWSEIVSNGTDAYYNYDFTAPERECPKCHESCTHGCWGEGPKNCQKFSKLTCSPQCAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEAVSKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKMDKGGECVPCNGPCPKTCPGVTVLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPERREVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAGTDQCLTCKNFNFNGTCIADCGYISNAYKFDNRTCKICHPECRTCNGAGADHCQECVHVRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRECFQRHPECNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASEEHVNLLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDEKDLIRKLAPTTDGSEAIAKPDDYLQPKAAPGPSHRTDCTDEMPKLNRYCKDPSNKNSSTGDDERDSSAREVGVGNLRLDLPVDEDDYLMPTCQPGPNNNNNMNNPNQNNMAAVGVAAGYMDLIGVPVSVDNPEYLLNAQTLGVGESPIPTQTIGIPVMGGPGTMEVKVPMPGSEPTSSDHEYYNDTQRELQPLHRNRNTETRV
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 128 | N-linked (GlcNAc...) asparagine |
|
||
| 241 | N-linked (GlcNAc...) asparagine |
|
||
| 419 | N-linked (GlcNAc...) asparagine |
|
||
| 443 | N-linked (GlcNAc...) asparagine |
|
||
| 482 | N-linked (GlcNAc...) asparagine |
|
||
| 569 | N-linked (GlcNAc...) asparagine |
|
||
| 599 | N-linked (GlcNAc...) asparagine |
|
||
| 617 | N-linked (GlcNAc...) asparagine |
|
||
| 816 | N-linked (GlcNAc...) asparagine |
|
||
| 823 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Cargo recognition for clathrin-mediated endocytosis | Drosophila melanogaster |
| Clathrin-mediated endocytosis | Drosophila melanogaster |
| Downregulation of ERBB2 signaling | Drosophila melanogaster |
| Downregulation of ERBB2:ERBB3 signaling | Drosophila melanogaster |
| Downregulation of ERBB4 signaling | Drosophila melanogaster |
| Drug-mediated inhibition of ERBB2 signaling | Drosophila melanogaster |
| EGFR Transactivation by Gastrin | Drosophila melanogaster |
| EGFR downregulation | Drosophila melanogaster |
| EGFR interacts with phospholipase C-gamma | Drosophila melanogaster |
| ERBB2 Regulates Cell Motility | Drosophila melanogaster |
