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Major prion protein

Summary

UniProt ID

P13852

Gene Symbol

Prnp
Prn
Prp

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: P13852

Annotation

Keyword

Cell membrane
Copper
Direct protein sequencing
Disulfide bond
GPI-anchor
Golgi apparatus
Metal-binding
Prion
Reference proteome
Repeat
Signal
Zinc

Gene Ontology (GO)

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GO Term
negative regulation of protein phosphorylation
response to oxidative stress
learning or memory
negative regulation of type II interferon production
negative regulation of catalytic activity
negative regulation of interleukin-17 production
negative regulation of interleukin-2 production
regulation of protein localization
negative regulation of apoptotic process
positive regulation of neuron apoptotic process

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GO Term
mitochondrial outer membrane
cell surface
postsynaptic density
side of membrane
dendrite
inclusion body
cytosol
membrane raft
endoplasmic reticulum
Golgi apparatus

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GO Term
protease binding
glycosaminoglycan binding
microtubule binding
tubulin binding
signaling receptor activity
protein-containing complex binding
metal ion binding
molecular adaptor activity
protein-folding chaperone binding
aspartic-type endopeptidase inhibitor activity

Annotation information from UniProt.

Sequence

MANLGYWLLALFVTTCTDVGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQSGGTWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWSQGGGTHNQWNKPSKPKTNLKHVAGAAAAGAVVGGLGGYMLGSAMSRPMLHFGNDWEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAYYDGRRSSAVLFSSPPVILLISFLIFLIVG

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites