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Cathepsin D

Summary

UniProt ID

P24268

Gene Symbol

Ctsd

Organism

Rattus norvegicus (Norway rat)

External Links

GlyGen: P24268
PubChem: P24268
The O-GlcNAc Database: P24268
Re-Glyco: P24268

Annotation

Keyword

3D-structure
Aspartyl protease
Direct protein sequencing
Disulfide bond
Glycoprotein
Lysosome
Reference proteome
Secreted
Signal
Zymogen

Gene Ontology (GO)

Displaying **all 9** entries
GO Term
membrane raft
presynaptic endosome
lysosomal membrane
endosome membrane
endosome lumen
GABA-ergic synapse
extracellular space
lysosome
melanosome

Displaying entries **1 - 10** of 11 in total

1

2

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GO Term
proteolysis
response to nutrient levels
positive regulation of apoptotic process
synaptic vesicle endosomal processing
regulation of establishment of protein localization
vesicle-mediated transport in synapse
autophagosome assembly
insulin receptor recycling
lipoprotein catabolic process
insulin catabolic process

Displaying **all 6** entries
GO Term
hydrolase activity
aspartic-type peptidase activity
endopeptidase activity
aspartic-type endopeptidase activity
peptidase activity
peptide binding

Annotation information from UniProt.

Sequence

MQTPGVLLLILGLLDASSSALIRIPLRKFTSIRRTMTEVGGSVEDLILKGPITKYSMQSSPRTKEPVSELLKNYLDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWVHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCKSDLGGIKVEKQIFGEATKQPGVVFIAAKFDGILGMGYPFISVNKVLPVFDNLMKQKLVEKNIFSFYLNRDPTGQPGGELMLGGTDSRYYHGELSYLNVTRKAYWQVHMDQLEVGSELTLCKGGCEAIVDTGTSLLVGPVDEVKELQKAIGAVPLIQGEYMIPCEKVSSLPIITFKLGGQNYELHPEKYILKVSQAGKTICLSGFMGMDIPPPSGPLWILGDVFIGCYYTVFDREYNRVGFAKAATL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
134	N-linked (GlcNAc...) asparagine		G41247ZX G80966KZ G02815KT G55220VL	UniProt GlyGen
255			G49108TO	The O-GlcNAc Database
258	N-linked (GlcNAc...) asparagine	24090084	G31852PQ G41247ZX G02815KT	UniProt GlyGen
260			G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
Collagen degradation	Rattus norvegicus
Insulin receptor recycling	Rattus norvegicus
MHC class II antigen presentation	Rattus norvegicus
Metabolism of Angiotensinogen to Angiotensins	Rattus norvegicus
Neutrophil degranulation	Rattus norvegicus