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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Malate dehydrogenase, cytoplasmic
Summary
- UniProt ID
- P40925
- Gene Symbol
-
- MDH1
- MDHA
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Alternative splicing
- Cytoplasm
- Direct protein sequencing
- Disease variant
- Epilepsy
- Methylation
- NAD
- Oxidoreductase
- Phosphoprotein
- Reference proteome
- Tricarboxylic acid cycle
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| tricarboxylic acid cycle |
| oxaloacetate metabolic process |
| malate metabolic process |
| NADH metabolic process |
| NADP metabolic process |
| gluconeogenesis |
| GO Term |
|---|
| mitochondrion |
| cytosol |
| centrosome |
| extracellular space |
| cytoplasm |
| extracellular exosome |
| GO Term |
|---|
| malic enzyme activity |
| L-malate dehydrogenase activity |
| diiodophenylpyruvate reductase activity |
| hydroxyphenylpyruvate reductase activity |
Sequence
MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA
Glycosylation Sites
G95177YH
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Malate-aspartate shuttle | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050433 | fatal familial insomnia | |
| DOID:0050572 | cone-rod dystrophy | |
| DOID:0050819 | obsolete Matthew-Wood syndrome | |
| DOID:0110423 | dilated cardiomyopathy 1C | |
| DOID:0110424 | dilated cardiomyopathy 1CC | |
| DOID:0110425 | dilated cardiomyopathy 1A | |
| DOID:0110426 | dilated cardiomyopathy 1D | |
| DOID:0110427 | dilated cardiomyopathy 1V | |
| DOID:0110428 | dilated cardiomyopathy 1AA | |
| DOID:0110429 | dilated cardiomyopathy 1H |
