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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Proprotein convertase subtilisin/kexin type 5
Summary
- UniProt ID
- P41413
- Gene Symbol
-
- Pcsk5
- Organism
- Rattus norvegicus (Norway rat)
External Links
- PubChem
- P41413
Annotation
- Keyword
-
- Alternative splicing
- Cleavage on pair of basic residues
- Glycoprotein
- Pregnancy
- Reference proteome
- Repeat
- Secreted
- Serine protease
- Signal
- Transmembrane helix
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular space |
| Golgi medial cisterna |
| trans-Golgi network |
| proximal dendrite |
| membrane |
| perikaryon |
| GO Term |
|---|
| peptidase activity |
| peptide binding |
| endopeptidase activity |
| serine-type endopeptidase activity |
Sequence
MDWGWGSRCCRPGRRDLLCVLALLAGCLLPVCRTRVYTNHWAVKIAGGFAEADRIASKYGFINVGQIGALKDYYHFYHSRTIKRSVLSSRGTHSFISMEPKVEWIQQQVVKKRTKRDYDLSRAQSTYFNDPKWPSMWYMHCSDNTHPCQSDMNIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTRCAGEVAATANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSYNPQHVHIYSASWGPDDDGKTVDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKPWYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRDVQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPQQHVCVESTDRQIKTIRPNSAVRSIYKASGCSDNPNHHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANRLFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGAEDYAGPCDPECSEVGCDGPGPDHCTDCLHYHYKLKNNTRICVSSCPPGHFHADKKRCRKCAPNCESCFGSHADQCLSCKYGYFLNEETSSCVAQCPEGSYQDIKKNICGKCSENCKTCTGFHNCTECKGGLSLQGSRCSVTCEDGQFFSGHDCQPCHRFCATCAGAGADGCINCTEGYVMEEGRCVQSCSVSYYLDHSLEGGYKSCKRCDNSCLTCNGPGFKNCSSCPSGYLLDLGMCQMGAICKDGEYIDEQGHCQICDASCAKCWGPTQDDCISCPITRVFDDGRCVMNCPSWKFELKKQCHPCHHTCQGCQGSGPSNCTSCKAGEFQDSEYGECMPCEEGCVGCTVDDPGACTSCATGYYMFERHCYKACPEKTFGEKWECKACGTNCGSCDQHECYWCEEGFFLSSGSCVQDCDPGFYGDQELGECKPCHRACETCTGLGYNQCSSCPEGLQLWHGTCIWPTWPHVEGKVWNEAVPTEKPSLVRSLPQDRRKWKVQIKRDATRQYQPCHSSCKTCNGSLCTSCPAGTYLWLQACVPSCPQGTWLSVRSSSCEKCAEGCASCSGDDLCQRCLSQPSNTLLLHEGRCYHSCPEGFYAKDGVCEHCSSPCKTCKGNATSCHSCEGDFVLDHGVCWETCPEKHVAVEGVCKHCPERCQDCIHEKTCKECMPDFFLYNDMCHHSCPKNFYPDMRQCVPCHKNCLGCNGPKEDDCKACADTSKVLHNGLCLDECPKGTYKDEVNDECRDCPESCLICSSAWTCLTCREGFTVVQDVCTAPKECAAIEYWDVGSHRCQPCHRKCSRCSGPSENQCYTCPRETFLLNTTCVKECPEGYHTDKDSHQCVPCHSSCRTCEGPHSMQCLSCRPGWFQLGKECLLQCRDGYYGESTSGRCEKCDKSCKTCRGPQPTDCQSCDTFFFLLRSKGQCHLACPEHYYADQHAQTCERCHPTCDKCSGKEAWNCLSCVWSYHLLKGICTPECIVGEYRDGKGENFNCKKCHESCMECKGPGSKNCTGCSAGLLLQMDDSRCLRCCNASHPHRSQDCCDCQSSTDECILPASDDTVFHEHTKTALLVTSGAMLLLLLGAAVVVWRKSRSQPVAKGRYEKLAEPTVSYSSYRSSYLDEDQVIEYRDRDYDEDDEDDIVYMGQDGTVYRKFKYGLLDEAEDDELEYDDESYSYQ
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 227 | N-linked (GlcNAc...) asparagine |
|
||
| 383 | N-linked (GlcNAc...) asparagine |
|
||
| 667 | N-linked (GlcNAc...) asparagine |
|
||
| 754 | N-linked (GlcNAc...) asparagine |
|
||
| 804 | N-linked (GlcNAc...) asparagine |
|
||
| 854 | N-linked (GlcNAc...) asparagine |
|
||
| 1642 | N-linked (GlcNAc...) asparagine |
|
||
| 1664 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Assembly of active LPL and LIPC lipase complexes | Rattus norvegicus |
| NGF processing | Rattus norvegicus |
