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Serine hydroxymethyltransferase, cytosolic

Summary

UniProt ID

P50431

Gene Symbol

Shmt1
Shmt

Organism

Mus musculus (house mouse)

External Links

GlyGen: P50431
PubChem: P50431
The O-GlcNAc Database: P50431
O-GlcNAcAtlas: P50431

Annotation

Keyword

3D-structure
Cytoplasm
Direct protein sequencing
One-carbon metabolism
Pyridoxal phosphate
Reference proteome
Transferase

Gene Ontology (GO)

Displaying entries **1 - 10** of 14 in total

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GO Term
cellular response to tetrahydrofolate
protein homotetramerization
cellular response to leukemia inhibitory factor
glycine biosynthetic process from serine
L-serine metabolic process
folic acid metabolic process
dTMP biosynthetic process
L-serine catabolic process
one-carbon metabolic process
purine nucleobase biosynthetic process

Displaying **all 5** entries
GO Term
nucleus
cytoplasm
mitochondrion
cytosol
nucleoplasm

Displaying entries **1 - 10** of 11 in total

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2

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GO Term
serine binding
cobalt ion binding
pyridoxal phosphate binding
identical protein binding
protein homodimerization activity
mRNA 5'-UTR binding
mRNA regulatory element binding translation repressor activity
glycine hydroxymethyltransferase activity
zinc ion binding
L-allo-threonine aldolase activity

Annotation information from UniProt.

Sequence

MADRDATLWASHEKMLSQPLKDSDAEVYSIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDELEMLCQKRALQAYHLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVYPETGYINYDQLEENASLFHPKLIIAGTSCYSRNLDYARLRKIADDNGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVRSVDPKTGKETYYELESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTTEFKIYQLQVLANCRALSDALTELGYKIVTGGSDNHLILMDLRSKGTDGGRAEKVLEACSIACNKNTCPGDKSALRPSGLRLGTPALTSRGLLEEDFQKVAHFIHRGIELTLQIQSHMATKATLKEFKEKLAGDEKIQSAVATLREEVENFASNFSLPGLPDF

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites