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Major prion protein

Summary

UniProt ID

P67992

Gene Symbol

PRNP
PRP

Organism

Macaca fascicularis (crab-eating macaque)

External Links

PubChem: P67992

Annotation

Keyword

Cell membrane
Copper
Disulfide bond
GPI-anchor
Golgi apparatus
Metal-binding
Prion
Reference proteome
Repeat
Signal
Zinc

Gene Ontology (GO)

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GO Term
negative regulation of protein phosphorylation
response to oxidative stress
learning or memory
negative regulation of type II interferon production
negative regulation of interleukin-17 production
negative regulation of interleukin-2 production
negative regulation of apoptotic process
positive regulation of neuron apoptotic process
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of protein localization to plasma membrane

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GO Term
Golgi apparatus
plasma membrane
nuclear membrane
terminal bouton
dendrite
inclusion body
cytosol
membrane raft
endoplasmic reticulum
cell surface

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GO Term
protease binding
glycosaminoglycan binding
microtubule binding
signaling receptor activity
protein-containing complex binding
aspartic-type endopeptidase inhibitor activity
type 5 metabotropic glutamate receptor binding
identical protein binding
molecular function activator activity
amyloid-beta binding

Annotation information from UniProt.

Sequence

MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHNQWHKPSKPKTSMKHMAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYEKESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites