GlyCosmos Portal

Submissions

Dihydropyrimidine dehydrogenase [NADP(+)]

Summary

UniProt ID

Q12882

Gene Symbol

DPYD

Organism

Homo sapiens (human)

External Links

GlyGen: Q12882
PubChem: Q12882
The Human Metabolome Database: HMDBP00727
The O-GlcNAc Database: Q12882
O-GlcNAcAtlas: Q12882

Annotation

Keyword

4Fe-4S
Acetylation
Alternative splicing
Cytoplasm
Direct protein sequencing
Disease variant
FAD
FMN
NADP
Nucleotide-binding
Oxidoreductase
Phosphoprotein
Reference proteome
Repeat

Gene Ontology (GO)

Displaying **all 10** entries
GO Term
beta-alanine biosynthetic process
UMP catabolic process
dUMP catabolic process
purine nucleobase catabolic process
pyrimidine nucleobase catabolic process
thymine catabolic process
uracil catabolic process
thymidine catabolic process
CMP catabolic process
dCMP catabolic process

Displaying **all 2** entries
GO Term
cytoplasm
cytosol

Displaying **all 7** entries
GO Term
uracil binding
metal ion binding
flavin adenine dinucleotide binding
NADP binding
4 iron, 4 sulfur cluster binding
dihydropyrimidine dehydrogenase (NADP+) activity
protein homodimerization activity

Annotation information from UniProt.

Sequence

MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKMIFSDNPLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEVFKAMSIPQIRNPSLPPPEKMSEAYSAKIALFGAGPASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDVVNFEIELMKDLGVKIICGKSLSVNEMTLSTLKEKGYKAAFIGIGLPEPNKDAIFQGLTQDQGFYTSKDFLPLVAKGSKAGMCACHSPLPSIRGVVIVLGAGDTAFDCATSALRCGARRVFIVFRKGFVNIRAVPEEMELAKEEKCEFLPFLSPRKVIVKGGRIVAMQFVRTEQDETGKWNEDEDQMVHLKADVVISAFGSVLSDPKVKEALSPIKFNRWGLPEVDPETMQTSEAWVFAGGDVVGLANTTVESVNDGKQASWYIHKYVQSQYGASVSAKPELPLFYTPIDLVDISVEMAGLKFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDWTELAKKSEDSGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSIARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGVSGTAIRPIALRAVTSIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYLKSIEELQDWDGQSPATVSHQKGKPVPRIAELMDKKLPSFGPYLEQRKKIIAENKIRLKEQNVAFSPLKRNCFIPKRPIPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCYMTCNDSGYQAIQFDPETHLPTITDTCTGCTLCLSVCPIVDCIKMVSRTTPYEPKRGVPLSVNPVC

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites