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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Chondroitin sulfate proteoglycan 4
Summary
- UniProt ID
- Q6UVK1
- Gene Symbol
-
- CSPG4
- MCSP
- Organism
- Homo sapiens (human)
External Links
- GlyConnect
- GlyGen
- Q6UVK1
- PubChem
- Q6UVK1
- The Human Metabolome Database
- HMDBP10791
- The O-GlcNAc Database
- Q6UVK1
Annotation
- Keyword
-
- 3D-structure
- Angiogenesis
- Cell membrane
- Cell projection
- Developmental protein
- Differentiation
- Disulfide bond
- Phosphoprotein
- Proteoglycan
- Reference proteome
- Repeat
- Signal
- Tissue remodeling
- Transducer
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| extracellular exosome |
| apical plasma membrane |
| lamellipodium membrane |
| ruffle |
| nucleoplasm |
| Golgi lumen |
| focal adhesion |
| cell surface |
| lysosomal lumen |
| extracellular region |
| GO Term |
|---|
| protein kinase binding |
| coreceptor activity |
Sequence
MQSGPRPPLPAPGLALALTLTMLARLASAASFFGENHLEVPVATALTDIDLQLQFSTSQPEALLLLAAGPADHLLLQLYSGRLQVRLVLGQEELRLQTPAETLLSDSIPHTVVLTVVEGWATLSVDGFLNASSAVPGAPLEVPYGLFVGGTGTLGLPYLRGTSRPLRGCLHAATLNGRSLLRPLTPDVHEGCAEEFSASDDVALGFSGPHSLAAFPAWGTQDEGTLEFTLTTQSRQAPLAFQAGGRRGDFIYVDIFEGHLRAVVEKGQGTVLLHNSVPVADGQPHEVSVHINAHRLEISVDQYPTHTSNRGVLSYLEPRGSLLLGGLDAEASRHLQEHRLGLTPEATNASLLGCMEDLSVNGQRRGLREALLTRNMAAGCRLEEEEYEDDAYGHYEAFSTLAPEAWPAMELPEPCVPEPGLPPVFANFTQLLTISPLVVAEGGTAWLEWRHVQPTLDLMEAELRKSQVLFSVTRGARHGELELDIPGAQARKMFTLLDVVNRKARFIHDGSEDTSDQLVLEVSVTARVPMPSCLRRGQTYLLPIQVNPVNDPPHIIFPHGSLMVILEHTQKPLGPEVFQAYDPDSACEGLTFQVLGTSSGLPVERRDQPGEPATEFSCRELEAGSLVYVHRGGPAQDLTFRVSDGLQASPPATLKVVAIRPAIQIHRSTGLRLAQGSAMPILPANLSVETNAVGQDVSVLFRVTGALQFGELQKQGAGGVEGAEWWATQAFHQRDVEQGRVRYLSTDPQHHAYDTVENLALEVQVGQEILSNLSFPVTIQRATVWMLRLEPLHTQNTQQETLTTAHLEATLEEAGPSPPTFHYEVVQAPRKGNLQLQGTRLSDGQGFTQDDIQAGRVTYGATARASEAVEDTFRFRVTAPPYFSPLYTFPIHIGGDPDAPVLTNVLLVVPEGGEGVLSADHLFVKSLNSASYLYEVMERPRHGRLAWRGTQDKTTMVTSFTNEDLLRGRLVYQHDDSETTEDDIPFVATRQGESSGDMAWEEVRGVFRVAIQPVNDHAPVQTISRIFHVARGGRRLLTTDDVAFSDADSGFADAQLVLTRKDLLFGSIVAVDEPTRPIYRFTQEDLRKRRVLFVHSGADRGWIQLQVSDGQHQATALLEVQASEPYLRVANGSSLVVPQGGQGTIDTAVLHLDTNLDIRSGDEVHYHVTAGPRWGQLVRAGQPATAFSQQDLLDGAVLYSHNGSLSPRDTMAFSVEAGPVHTDATLQVTIALEGPLAPLKLVRHKKIYVFQGEAAEIRRDQLEAAQEAVPPADIVFSVKSPPSAGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGRVLYLHSRPEAWSDAFSLDVASGLGAPLEGVLVELEVLPAAIPLEAQNFSVPEGGSLTLAPPLLRVSGPYFPTLLGLSLQVLEPPQHGALQKEDGPQARTLSAFSWRMVEEQLIRYVHDGSETLTDSFVLMANASEMDRQSHPVAFTVTVLPVNDQPPILTTNTGLQMWEGATAPIPAEALRSTDGDSGSEDLVYTIEQPSNGRVVLRGAPGTEVRSFTQAQLDGGLVLFSHRGTLDGGFRFRLSDGEHTSPGHFFRVTAQKQVLLSLKGSQTLTVCPGSVQPLSSQTLRASSSAGTDPQLLLYRVVRGPQLGRLFHAQQDSTGEALVNFTQAEVYAGNILYEHEMPPEPFWEAHDTLELQLSSPPARDVAATLAVAVSFEAACPQRPSHLWKNKGLWVPEGQRARITVAALDASNLLASVPSPQRSEHDVLFQVTQFPSRGQLLVSEEPLHAGQPHFLQSQLAAGQLVYAHGGGGTQQDGFHFRAHLQGPAGASVAGPQTSEAFAITVRDVNERPPQPQASVPLRLTRGSRAPISRAQLSVVDPDSAPGEIEYEVQRAPHNGFLSLVGGGLGPVTRFTQADVDSGRLAFVANGSSVAGIFQLSMSDGASPPLPMSLAVDILPSAIEVQLRAPLEVPQALGRSSLSQQQLRVVSDREEPEAAYRLIQGPQYGHLLVGGRPTSAFSQFQIDQGEVVFAFTNFSSSHDHFRVLALARGVNASAVVNVTVRALLHVWAGGPWPQGATLRLDPTVLDAGELANRTGSVPRFRLLEGPRHGRVVRVPRARTEPGGSQLVEQFTQQDLEDGRLGLEVGRPEGRAPGPAGDSLTLELWAQGVPPAVASLDFATEPYNAARPYSVALLSVPEAARTEAGKPESSTPTGEPGPMASSPEPAVAKGGFLSFLEANMFSVIIPMCLVLLLLALILPLLFYLRKRNKTGKHDVQVLTAKPRNGLAGDTETFRKVEPGQAIPLTAVPGQGPPPGGQPDPELLQFCRTPNPALKNGQYWV
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 130 | N-linked (GlcNAc...) asparagine |
|
||
| 348 | N-linked (GlcNAc...) asparagine | |||
| 427 | N-linked (GlcNAc...) asparagine |
|
||
| 685 | N-linked (GlcNAc...) asparagine | |||
| 772 | N-linked (GlcNAc...) asparagine | |||
| 995 | O-linked (Xyl...) (chondroitin sulfate) serine |
|
||
| 1131 | N-linked (GlcNAc...) asparagine | |||
| 1160 |
|
|||
| 1202 | N-linked (GlcNAc...) asparagine | |||
| 1364 | N-linked (GlcNAc...) asparagine |
|
G45395BF
G59324HL
G14972EH
G43223CG
G27915IV
G23505EP
G04657PL
G27058EU
G60033FS
G41071NU
G80920RR
G73968GN
G65184UU
G42124LM
G02886BB
G72790NZ
G10486CT
G02815KT
G92050GC
G03246PF
G49108TO
G20706XG
G95865ZB
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| A tetrasaccharide linker sequence is required for GAG synthesis | Homo sapiens |
| CS/DS degradation | Homo sapiens |
| Chondroitin sulfate biosynthesis | Homo sapiens |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | Homo sapiens |
| Defective B3GAT3 causes JDSSDHD | Homo sapiens |
| Defective B4GALT7 causes EDS, progeroid type | Homo sapiens |
| Defective CHST14 causes EDS, musculocontractural type | Homo sapiens |
| Defective CHST3 causes SEDCJD | Homo sapiens |
| Defective CHSY1 causes TPBS | Homo sapiens |
| Dermatan sulfate biosynthesis | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050558 | Ullrich congenital muscular dystrophy | |
| DOID:0050848 | obstructive sleep apnea | |
| DOID:0060180 | colitis | |
| DOID:0060189 | ileitis | |
| DOID:0060190 | ileocolitis | |
| DOID:0080147 | lymphoblastic lymphoma | |
| DOID:0080348 | Alzheimer's disease 1 | |
| DOID:0110035 | Alzheimer's disease 2 | |
| DOID:0110037 | Alzheimer's disease 5 | |
| DOID:0110038 | Alzheimer's disease 6 |
