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Alpha-actinin-2

Summary

UniProt ID

Q9JI91

Gene Symbol

Actn2

Organism

Mus musculus (house mouse)

External Links

GlyGen: Q9JI91
PubChem: Q9JI91
The O-GlcNAc Database: Q9JI91
RaftProt: Q9JI91

Annotation

Keyword

Actin-binding
Calcium
Cytoplasm
Metal-binding
Phosphoprotein
Reference proteome
Repeat
Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 10** of 16 in total

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GO Term
muscle contraction
actin cytoskeleton organization
regulation of membrane potential
sarcomere organization
muscle cell development
cardiac muscle cell development
protein localization to plasma membrane
positive regulation of cation channel activity
actin filament uncapping
negative regulation of protein localization to cell surface

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GO Term
plasma membrane
sarcomere
cell junction
cell projection
postsynaptic actin cytoskeleton
glutamatergic synapse
Z disc
filopodium
striated muscle thin filament
focal adhesion

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GO Term
calcium ion binding
protein-macromolecule adaptor activity
actin filament binding
phosphatidylinositol-4,5-bisphosphate binding
titin Z domain binding
cytoskeletal protein binding
FATZ binding
LIM domain binding
nuclear receptor coactivator activity
titin binding

Annotation information from UniProt.

Sequence

MNQIEPGVQYNYVYDEDEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERTEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSILAIQNEVEKVIQSYSIRISSSNPYSTVTMDELRNKWDKVKQLVPVRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINEVETQILTRDAKGITQEQMNEFRASFNHFDRRKNGLMDHEDFRACLISMGYDLGEAEFARIMTLVDPNGQGTVTFQSFIDFMTRETADTDTAEQVIASFRILASDKPYILAEELRRELPPDQAQYCIKRMPPYSGPGSVPGALDYTAFSSALYGESDL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
714			G31852PQ	GlyGen
			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Platelet degranulation	Mus musculus
RAF/MAP kinase cascade	Mus musculus
Striated Muscle Contraction	Mus musculus
Unblocking of NMDA receptors, glutamate binding and activation	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Summary

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Annotation

International Collaboration

Acknowledgements