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Rap guanine nucleotide exchange factor 2

Summary

UniProt ID

Q9Y4G8

Gene Symbol

RAPGEF2
KIAA0313
NRAPGEP
PDZGEF1

Organism

Homo sapiens (human)

External Links

GlyGen: Q9Y4G8
PubChem: Q9Y4G8
The Human Metabolome Database: HMDBP01123
The O-GlcNAc Database: Q9Y4G8
O-GlcNAcAtlas: Q9Y4G8

Annotation

Keyword

3D-structure
Cell junction
Cell membrane
Cytoplasm
Developmental protein
Differentiation
Endosome
Epilepsy
GTPase activation
Guanine-nucleotide releasing factor
Neurogenesis
Phosphoprotein
Reference proteome
Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 10** of 37 in total

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GO Term
regulation of synaptic plasticity
blood vessel development
neuron migration
G protein-coupled receptor signaling pathway
positive regulation of neuron projection development
cAMP-mediated signaling
ventricular system development
neuron projection development
Rap protein signal transduction
positive regulation of ERK1 and ERK2 cascade

Displaying entries **1 - 10** of 14 in total

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GO Term
late endosome
cytosol
apical plasma membrane
endocytic vesicle
perinuclear region of cytoplasm
cytoplasm
plasma membrane
cell-cell junction
membrane
protein-containing complex

Displaying **all 9** entries
GO Term
calcium ion binding
WW domain binding
guanyl-nucleotide exchange factor activity
GTPase activator activity
cAMP binding
diacylglycerol binding
PDZ domain binding
beta-1 adrenergic receptor binding
phosphatidic acid binding

Annotation information from UniProt.

Sequence

MKPLAIPANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEEKRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKTRISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFSATPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATNTLPKNPGDKKPVKSETSPVAPRAGSQQKAQSLPQPQQQPPPAHKINQGLQVPAVSLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQSSPRKGYTLAPSGTVDNFSDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQRHSVSIVETNLGMGRMERRTMIEPDQYSLGSYAPMSEGRGLYATATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWETLPFGHTHFDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSIEAESSSLTSVTTEETKPVPMPAHIAVASSTTKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPARKPPDYNVALQRSRMVARSSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFSTEEDEDEQVSAV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites