GlyCOVID
GlyCOVID is a dataset of RDFized COVID-19 data related to glycans. Resources will be added incrementally as publications are curated.
Longitudinal Development of Antibody Responses in COVID-19 Patients of Different Severity with ELISA, Peptide, and Glycan Arrays: An Immunological Case Series.
Heidepriem J, et al.
Pathogens. 2021; 10(4):438. https://doi.org/10.3390/pathogens10040438
A longitudinal analysis of three COVID-19 patients with moderate (#1) and mild disease (#2 and #3) was published. Antibody serum responses were analyzed using spike glycoprotein enzyme linked immunosorbent assay (ELISA), full-proteome peptide, and glycan microarrays. In this Glycovid dataset, the data from these glycan microarray experiments have been RDFized. Fluorescence intensity is given in arbitrary fluorescence units (AFU) as reported in this publication.
| Antibody | Patient | Onset (days) | Symptom | GlyTouCan ID | Arbitrary Fluorescence Units (AFU) |
|---|---|---|---|---|---|
|
IgG
|
Patient 1
|
22
|
moderate
|
106
|
|
|
IgG
|
Patient 3
|
4
|
mild
|
105
|
|
|
IgG
|
Patient 3
|
-180
|
mild
|
159
|
|
|
IgM
|
Patient 2
|
3
|
mild
|
71
|
|
|
IgA
|
Patient 2
|
15
|
mild
|
372
|
|
|
IgA
|
Patient 1
|
22
|
moderate
|
426
|
|
|
IgM
|
Patient 1
|
10
|
moderate
|
33
|
|
|
IgG
|
Patient 2
|
15
|
mild
|
49
|
|
|
IgM
|
Patient 2
|
24
|
mild
|
46
|
|
|
IgG
|
Patient 3
|
-180
|
mild
|
1230
|
International Collaboration
GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.
Acknowledgements
Supported by JST NBDC Grant Number JPMJND2204
Partly supported by NIH Common Fund Grant #1U01GM125267-01
