GlyCosmos Portal

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Ficolin-2

Summary

Organism: Rattus norvegicus (Norway rat)

External Links

UniProt: P57756

Annotation

Keyword

Calcium
Collagen
Complement activation lectin pathway
Disulfide bond
Glycoprotein
Lectin
Metal-binding
Reference proteome
Repeat
Secreted
Signal

Gene Ontology (GO)

Displaying **all 9** entries
GO Term
proteolysis
G protein-coupled receptor signaling pathway
cell surface pattern recognition receptor signaling pathway
positive regulation of interleukin-8 production
protein localization to cell surface
complement activation, lectin pathway
recognition of apoptotic cell
negative regulation of viral entry into host cell
positive regulation of opsonization

Displaying **all 5** entries
GO Term
collagen trimer
extracellular space
plasma membrane
collagen-containing extracellular matrix
serine-type endopeptidase complex

Displaying **all 8** entries
GO Term
signaling receptor binding
carbohydrate binding
pattern recognition receptor activity
metal ion binding
antigen binding
sialic acid binding
G protein-coupled receptor binding
carbohydrate derivative binding

Annotation information from UniProt.

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Ficolins bind to repetitive carbohydrate structures on the target cell surface	Rattus norvegicus
Initial triggering of complement	Rattus norvegicus
Lectin pathway of complement activation	Rattus norvegicus
Neutrophil degranulation	Rattus norvegicus

MCAW-DB (Glycan Recognition Profile)

MCAW-DB is a database whereby users can view the multiple alignment analysis results obtained from the MCAW tool, which can computationally find common glycan substructures among a group of glycan structures. The data in MCAW-DB are analysis results of glycan array experiments; those glycans having higher binding affinity to glycan binding proteins (GBPs) have been analyzed and can be viewed as “glycan recognition profiles”. Currently, this database provides published analysis results of glycan array data from the Consortium for Functional Glycomics (CFG).