GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	Short Names	Lectin Name All	UniProt ID	PDB IDs	LfDB IDs	Species	Taxonomy ID	MCAW IDs ▲	GO Labels	GO IDs
GL_002341	Mannose-binding protein C		Mannose-binding protein C	P11226	1HUP		Homo sapiens	9606	1641	acute-phase response antiviral innate immune response calcium-dependent protein binding cell surface cell surface pattern recognition receptor signaling pathway collagen trimer complement activation, classical pathway complement activation, lectin pathway defense response to Gram-positive bacterium defense response to bacterium external side of plasma membrane extracellular region extracellular space identical protein binding innate immune response killing by host of symbiont cells mannose binding multivesicular body negative regulation of viral process opsonization positive regulation of opsonization positive regulation of phagocytosis proteolysis response to oxidative stress serine-type endopeptidase complex signaling receptor binding surfactant homeostasis	GO:0001867 GO:0002752 GO:0005102 GO:0005537 GO:0005576 GO:0005581 GO:0005615 GO:0005771 GO:0006508 GO:0006953 GO:0006958 GO:0006979 GO:0008228 GO:0009897 GO:0009986 GO:0042742 GO:0042802 GO:0043129 GO:0045087 GO:0048306 GO:0048525 GO:0050766 GO:0050830 GO:0051873 GO:0140374 GO:1903028 GO:1905370
GL_001078	Ricin B-like lectin		Ricin B-like lectin	B2ZRS9	3NBC 3NBD 3NBE		Clitocybe nebularis	117024	1679 1682 1684 1685 1692 1693 1695 1696 1697	carbohydrate binding protein homodimerization activity	GO:0030246 GO:0042803
GL_000471	Galectin-1		Galectin-1	P16045	4LBQ		Mus musculus	10090	1704 1709 1722	T cell costimulation apoptotic process carbohydrate binding cell surface cell-cell adhesion collagen-containing extracellular matrix cytosol extracellular region extracellular space galactose binding galectin complex heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules identical protein binding lactose binding laminin binding myoblast differentiation negative regulation of cell-substrate adhesion negative regulation of neuron projection development plasma cell differentiation positive regulation of apoptotic process positive regulation of erythrocyte aggregation positive regulation of inflammatory response positive regulation of viral entry into host cell	GO:0002317 GO:0005534 GO:0005576 GO:0005615 GO:0005829 GO:0006915 GO:0007157 GO:0009986 GO:0010812 GO:0010977 GO:0030246 GO:0030395 GO:0031295 GO:0034120 GO:0042802 GO:0043065 GO:0043236 GO:0045445 GO:0046598 GO:0050729 GO:0062023 GO:0098609 GO:1990724
GL_000189	C-type lectin domain family 4 member K		C-type lectin domain family 4 member K	Q9UJ71	3C22 3KQG 3P5D 3P5E 3P5F 3P5G 3P5H 3P5I 3P7F 3P7G 3P7H 4AK8 4N32 4N33 4N34 4N35 4N36 4N37 4N38 5G6U 7WZ8 7YTQ		Homo sapiens	9606	1842 5090	carbohydrate binding clathrin-coated endocytic vesicle membrane defense response to virus early endosome membrane endocytic vesicle external side of plasma membrane mannose binding plasma membrane	GO:0005537 GO:0005886 GO:0009897 GO:0030139 GO:0030246 GO:0030669 GO:0031901 GO:0051607
GL_002327	Type 1 fimbrin D-mannose specific adhesin		Type 1 fimbrin D-mannose specific adhesin	P08191	1KIU 1KLF 1QUN 1TR7 1UWF 1ZE3 2VCO 3RFZ 3ZL1 3ZL2 4ATT 4AUJ 4AUU 4AUY 4AV0 4AV4 4AV5 4AVH 4AVI 4AVJ 4AVK 4CSS 4CST 4J3O 4LOV 4X50 4X5P 4X5Q 4X5R 4XO8 4XO9 4XOA 4XOB 4XOD 5ABZ 5CGB 5F2F 5F3F 5FS5 5FWR 5FX3 5JCQ 5JCR 5L4T 5L4U 5L4V 5L4W 5L4X 5L4Y 5MCA 5MTS 5MUC 6E14 6E15 6G2R 6G2S 6GTX 6GTY 6YHW 7AYN 7BHD 7SZO 8BVD 8BXY 8BY3		Escherichia coli K-12	83333	1890 2517 2518 2520	cell adhesion cell adhesion involved in single-species biofilm formation cell-substrate adhesion host cell membrane mannose binding mechanosensory behavior pilus pilus tip	GO:0005537 GO:0007155 GO:0007638 GO:0009289 GO:0009419 GO:0031589 GO:0033644 GO:0043709
GL_000514	Galectin-9	Galectin-9	Galectin-9 Galectin-9	O00182	2EAK 2EAL 2YY1 2ZHK 2ZHL 2ZHM 2ZHN 3LSD 3LSE 3NV1 3NV2 3NV3 3NV4 3WLU 3WV6	LfDB0274	Homo sapiens	9606	1935 2987	ERK1 and ERK2 cascade carbohydrate binding cellular response to type II interferon cellular response to virus chemotaxis collagen-containing extracellular matrix cytoplasm cytosol disaccharide binding enzyme binding extracellular space female pregnancy galactose binding galactoside binding inflammatory response maternal process involved in female pregnancy natural killer cell tolerance induction negative regulation of CD4-positive, alpha-beta T cell proliferation negative regulation of activated T cell proliferation negative regulation of chemokine production negative regulation of gene expression negative regulation of mast cell degranulation negative regulation of natural killer cell mediated cytotoxicity negative regulation of tumor necrosis factor production negative regulation of type II interferon production nucleus p38MAPK cascade positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response positive regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of ERK1 and ERK2 cascade positive regulation of NF-kappaB transcription factor activity positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell positive regulation of activated T cell autonomous cell death positive regulation of canonical NF-kappaB signal transduction positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway positive regulation of dendritic cell apoptotic process positive regulation of dendritic cell chemotaxis positive regulation of dendritic cell differentiation positive regulation of gene expression positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of monocyte chemotactic protein-1 production positive regulation of non-canonical NF-kappaB signal transduction positive regulation of transforming growth factor beta production positive regulation of tumor necrosis factor production positive regulation of type II interferon production positive regulation of viral entry into host cell response to interleukin-1 response to lipopolysaccharide	GO:0002519 GO:0005534 GO:0005615 GO:0005634 GO:0005737 GO:0005829 GO:0006935 GO:0006954 GO:0007565 GO:0010628 GO:0010629 GO:0016936 GO:0019899 GO:0030246 GO:0032496 GO:0032682 GO:0032689 GO:0032720 GO:0032729 GO:0032731 GO:0032733 GO:0032735 GO:0032736 GO:0032753 GO:0032755 GO:0032757 GO:0032760 GO:0032834 GO:0038066 GO:0043123 GO:0043305 GO:0045953 GO:0046007 GO:0046598 GO:0048030 GO:0051092 GO:0060135 GO:0062023 GO:0070241 GO:0070371 GO:0070374 GO:0070555 GO:0071346 GO:0071636 GO:0071639 GO:0098586 GO:1901224 GO:2000510 GO:2000562 GO:2000563 GO:2000670 GO:2001190 GO:2001200 GO:2001269
GL_002074	Sialic acid-binding Ig-like lectin 5		Sialic acid-binding Ig-like lectin 5	Q920G3			Mus musculus	10090	1943 386	cell adhesion lysosome monosaccharide binding plasma membrane regulation of endocytosis sialic acid binding	GO:0005764 GO:0005886 GO:0007155 GO:0030100 GO:0033691 GO:0048029
GL_001121	Sialic acid-binding Ig-like lectin 7		Sialic acid-binding Ig-like lectin 7	Q9Y286	1NKO 1O7S 1O7V 2DF3 2G5R 2HRL		Homo sapiens	9606	1976 5378 5388	carbohydrate binding cell adhesion plasma membrane sialic acid binding signaling receptor activity	GO:0005886 GO:0007155 GO:0030246 GO:0033691 GO:0038023
GL_000486	Galectin-2		Galectin-2	Q9P4R8	1UL9 1ULC 1ULD 1ULE 1ULF 1ULG 2WKK		Coprinopsis cinerea	5346	2107 2108 5314 5356	carbohydrate binding endomembrane system extracellular region membrane	GO:0005576 GO:0012505 GO:0016020 GO:0030246
GL_002232	Epa1p		Epa1p	Q6VBJ0	4A3X 4AF9 4AFA 4AFB 4AFC		Nakaseomyces glabratus	5478	2353 2354 5353 5365	cell surface metal ion binding	GO:0009986 GO:0046872