GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name ▲	Lectin Name All	UniProt ID	PDB IDs	Species	Taxonomy ID	GO Labels	GO IDs
GL_001834	Signal transducer CD24	Signal transducer CD24	P24807		Mus musculus	10090	B cell apoptotic process B cell proliferation B cell receptor transport into membrane raft CD4-positive, alpha-beta T cell proliferation Hsp70 protein binding Hsp90 protein binding T cell costimulation T cell homeostatic proliferation apoptotic mitochondrial changes apoptotic nuclear changes apoptotic signaling pathway calcium-mediated signaling carbohydrate binding cell activation cell migration cell surface cell surface receptor signaling pathway chemokine receptor transport out of membrane raft cholesterol homeostasis ciliary membrane external side of plasma membrane glomerular parietal epithelial cell differentiation heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules homotypic cell-cell adhesion innate immune response integrin activation intracellular membrane-bounded organelle leukocyte cell-cell adhesion leukocyte migration involved in inflammatory response membrane membrane raft microvillus membrane motile cilium negative regulation of B cell proliferation negative regulation of T cell homeostatic proliferation negative regulation of erythrocyte aggregation negative regulation of erythrocyte clearance negative regulation of inflammatory response to wounding negative regulation of interleukin-6 production negative regulation of monocyte chemotactic protein-1 production negative regulation of neuroblast proliferation negative regulation of neurogenesis negative regulation of neuron differentiation negative regulation of transforming growth factor beta3 production negative regulation of tumor necrosis factor production neuroblast proliferation neuromuscular synaptic transmission neuron projection development plasma membrane podocyte differentiation positive regulation of B cell apoptotic process positive regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of MAP kinase activity positive regulation of T cell homeostatic proliferation positive regulation of T cell mediated immune response to tumor cell positive regulation of activated T cell proliferation positive regulation of alpha-beta T cell proliferation positive regulation of calcium-mediated signaling positive regulation of cell adhesion mediated by integrin positive regulation of cell-cell adhesion positive regulation of cell-cell adhesion mediated by integrin positive regulation of cytosolic calcium ion concentration positive regulation of inflammatory response to antigenic stimulus positive regulation of inflammatory response to wounding positive regulation of integrin activation positive regulation of nephron tubule epithelial cell differentiation positive regulation of neuron projection development positive regulation of peptidyl-tyrosine phosphorylation pre-B cell differentiation presynapse protein kinase binding protein tyrosine kinase activator activity regulation of B cell differentiation regulation of MAPK cascade regulation of cell-cell adhesion regulation of cell-cell adhesion mediated by integrin regulation of cytokine-mediated signaling pathway regulation of phosphorylation respiratory burst response to estrogen response to hypoxia response to molecule of bacterial origin synaptic vesicle endocytosis	GO:0001666 GO:0001775 GO:0001777 GO:0001783 GO:0001959 GO:0002237 GO:0002329 GO:0002523 GO:0002842 GO:0002863 GO:0002904 GO:0005886 GO:0007157 GO:0007159 GO:0007166 GO:0007204 GO:0007274 GO:0007405 GO:0007406 GO:0008637 GO:0009897 GO:0009986 GO:0010976 GO:0016020 GO:0016477 GO:0019722 GO:0019901 GO:0022407 GO:0022409 GO:0030246 GO:0030262 GO:0030296 GO:0030544 GO:0030889 GO:0031175 GO:0031295 GO:0031514 GO:0031528 GO:0032597 GO:0032600 GO:0032715 GO:0032720 GO:0032913 GO:0033622 GO:0033625 GO:0033630 GO:0033632 GO:0033634 GO:0034107 GO:0034109 GO:0034119 GO:0035739 GO:0042100 GO:0042103 GO:0042104 GO:0042325 GO:0042632 GO:0043231 GO:0043406 GO:0043408 GO:0043627 GO:0045087 GO:0045121 GO:0045577 GO:0045665 GO:0045730 GO:0046014 GO:0046641 GO:0048488 GO:0050731 GO:0050768 GO:0050850 GO:0051879 GO:0060170 GO:0071638 GO:0072112 GO:0072139 GO:0097190 GO:0098793 GO:0106015 GO:0106016 GO:2000563 GO:2000768
GL_001833	Signal transducer CD24	Signal transducer CD24	Q07490		Rattus norvegicus	10116	B cell apoptotic process B cell proliferation B cell receptor transport into membrane raft CD4-positive, alpha-beta T cell proliferation Hsp70 protein binding Hsp90 protein binding T cell costimulation T cell homeostatic proliferation apoptotic mitochondrial changes apoptotic nuclear changes apoptotic signaling pathway calcium-mediated signaling carbohydrate binding cell activation cell migration cell surface cell surface receptor signaling pathway chemokine receptor transport out of membrane raft cholesterol homeostasis ciliary membrane external side of plasma membrane glomerular parietal epithelial cell differentiation heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules homotypic cell-cell adhesion immune response integrin activation leukocyte cell-cell adhesion leukocyte migration involved in inflammatory response membrane membrane raft microvillus membrane motile cilium negative regulation of B cell proliferation negative regulation of T cell homeostatic proliferation negative regulation of erythrocyte aggregation negative regulation of erythrocyte clearance negative regulation of inflammatory response to wounding negative regulation of interleukin-6 production negative regulation of monocyte chemotactic protein-1 production negative regulation of neuroblast proliferation negative regulation of neurogenesis negative regulation of neuron differentiation negative regulation of transforming growth factor beta3 production negative regulation of tumor necrosis factor production neuroblast proliferation neuromuscular synaptic transmission neuron projection development plasma membrane podocyte differentiation positive regulation of B cell apoptotic process positive regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of MAP kinase activity positive regulation of T cell homeostatic proliferation positive regulation of T cell mediated immune response to tumor cell positive regulation of activated T cell proliferation positive regulation of alpha-beta T cell proliferation positive regulation of calcium-mediated signaling positive regulation of cell adhesion mediated by integrin positive regulation of cell-cell adhesion positive regulation of cell-cell adhesion mediated by integrin positive regulation of cytosolic calcium ion concentration positive regulation of inflammatory response to antigenic stimulus positive regulation of inflammatory response to wounding positive regulation of integrin activation positive regulation of nephron tubule epithelial cell differentiation positive regulation of neuron projection development positive regulation of peptidyl-tyrosine phosphorylation pre-B cell differentiation presynapse protein kinase binding protein tyrosine kinase activator activity regulation of B cell differentiation regulation of MAPK cascade regulation of cell-cell adhesion regulation of cell-cell adhesion mediated by integrin regulation of cytokine-mediated signaling pathway regulation of phosphorylation respiratory burst response to estrogen response to hypoxia response to molecule of bacterial origin synaptic vesicle endocytosis	GO:0001666 GO:0001775 GO:0001777 GO:0001783 GO:0001959 GO:0002237 GO:0002329 GO:0002523 GO:0002842 GO:0002863 GO:0002904 GO:0005886 GO:0006955 GO:0007157 GO:0007159 GO:0007166 GO:0007204 GO:0007274 GO:0007405 GO:0007406 GO:0008637 GO:0009897 GO:0009986 GO:0010976 GO:0016020 GO:0016477 GO:0019722 GO:0019901 GO:0022407 GO:0022409 GO:0030246 GO:0030262 GO:0030296 GO:0030544 GO:0030889 GO:0031175 GO:0031295 GO:0031514 GO:0031528 GO:0032597 GO:0032600 GO:0032715 GO:0032720 GO:0032913 GO:0033622 GO:0033625 GO:0033630 GO:0033632 GO:0033634 GO:0034107 GO:0034109 GO:0034119 GO:0035739 GO:0042100 GO:0042103 GO:0042104 GO:0042325 GO:0042632 GO:0043406 GO:0043408 GO:0043627 GO:0045121 GO:0045577 GO:0045665 GO:0045730 GO:0046014 GO:0046641 GO:0048488 GO:0050731 GO:0050768 GO:0050850 GO:0051879 GO:0060170 GO:0071638 GO:0072112 GO:0072139 GO:0097190 GO:0098793 GO:0106015 GO:0106016 GO:2000563 GO:2000768
GL_001128	Snaclec coagulation factor X-activating enzyme light chain 2 (Fragment)	Snaclec coagulation factor X-activating enzyme light chain 2 (Fragment)	Q7LZ24		Vipera aspis aspis	194601	carbohydrate binding extracellular region metal ion binding toxin activity	GO:0005576 GO:0030246 GO:0046872 GO:0090729
GL_001129	Snaclec jerdonuxin subunit alpha	Snaclec jerdonuxin subunit alpha	E2DQZ6		Protobothrops jerdonii	242841	carbohydrate binding extracellular region toxin activity	GO:0005576 GO:0030246 GO:0090729
GL_001130	Snaclec jerdonuxin subunit beta	Snaclec jerdonuxin subunit beta	E2DQZ5		Protobothrops jerdonii	242841	carbohydrate binding extracellular region toxin activity	GO:0005576 GO:0030246 GO:0090729
GL_001131	Snaclec subunit B	Snaclec subunit B	Q09GK0		Philodryas olfersii	120305	carbohydrate binding extracellular region toxin activity	GO:0005576 GO:0030246 GO:0090729
GL_001835	Sorbitol dehydrogenase	Sorbitol dehydrogenase	Q00796	1PL6 1PL7 1PL8	Homo sapiens	9606	(R,R)-butanediol dehydrogenase activity D-sorbitol dehydrogenase (acceptor) activity D-xylulose reductase activity L-iditol 2-dehydrogenase activity L-xylitol catabolic process L-xylitol metabolic process NAD binding carbohydrate binding cytosol extracellular exosome extracellular space flagellated sperm motility fructose biosynthetic process glucose metabolic process glucuronate catabolic process to xylulose 5-phosphate identical protein binding membrane mitochondrial membrane motile cilium ribitol 2-dehydrogenase activity sorbitol catabolic process zinc ion binding	GO:0000721 GO:0003939 GO:0005615 GO:0005829 GO:0006006 GO:0006062 GO:0008270 GO:0016020 GO:0019640 GO:0030246 GO:0030317 GO:0031514 GO:0031966 GO:0042802 GO:0046370 GO:0046526 GO:0047833 GO:0050255 GO:0051160 GO:0051164 GO:0051287 GO:0070062
GL_001836	Sorbitol operon regulator	Sorbitol operon regulator	P37078	2W48	Klebsiella pneumoniae	573	DNA binding carbohydrate binding	GO:0003677 GO:0030246
GL_001132	Sperm receptor for egg jelly	Sperm receptor for egg jelly	Q26627		Strongylocentrotus purpuratus	7668	calcium channel activity calcium ion binding carbohydrate binding detection of mechanical stimulus membrane plasma membrane	GO:0005262 GO:0005509 GO:0005886 GO:0016020 GO:0030246 GO:0050982
GL_001837	Spike glycoprotein	Spike glycoprotein	P36334	7M51 7PNM 7PNQ 7PO5	Human coronavirus OC43	31631	carbohydrate binding endocytosis involved in viral entry into host cell fusion of virus membrane with host endosome membrane fusion of virus membrane with host plasma membrane host cell endoplasmic reticulum-Golgi intermediate compartment membrane host cell plasma membrane host cell surface receptor binding membrane receptor-mediated virion attachment to host cell viral envelope virion membrane	GO:0016020 GO:0019031 GO:0019064 GO:0020002 GO:0030246 GO:0039654 GO:0044173 GO:0046789 GO:0046813 GO:0055036 GO:0075509