GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	Short Names	Lectin Name All	UniProt ID	PDB IDs	LfDB IDs	Species	Taxonomy ID ▲	MCAW IDs	GO Labels	GO IDs
GL_000149	C-type lectin domain family 14 member A		C-type lectin domain family 14 member A	Q86T13			Homo sapiens	9606		carbohydrate binding cell migration cell migration involved in sprouting angiogenesis collagen-containing extracellular matrix external side of plasma membrane extracellular matrix binding extracellular matrix protein binding lymphangiogenesis vascular endothelial growth factor receptor-2 signaling pathway vascular endothelial growth factor receptor-3 signaling pathway	GO:0001946 GO:0002042 GO:0009897 GO:0016477 GO:0030246 GO:0036324 GO:0036325 GO:0050840 GO:0062023 GO:1990430
GL_001123	Sialic acid-binding Ig-like lectin 9		Sialic acid-binding Ig-like lectin 9	Q9Y336			Homo sapiens	9606		carbohydrate binding cell adhesion cell surface receptor signaling pathway plasma membrane secretory granule membrane sialic acid binding	GO:0005886 GO:0007155 GO:0007166 GO:0030246 GO:0030667 GO:0033691
GL_000516	Galectin-9B		Galectin-9B	Q3B8N2			Homo sapiens	9606		carbohydrate binding cytosol galactoside binding negative regulation of CD4-positive, alpha-beta T cell proliferation negative regulation of type II interferon production nucleus positive regulation of gene expression	GO:0005634 GO:0005829 GO:0010628 GO:0016936 GO:0030246 GO:0032689 GO:2000562
GL_002384	CD83 antigen		CD83 antigen	Q01151	5MIX 5MJ0 5MJ1 5MJ2		Homo sapiens	9606		CD4-positive, alpha-beta T cell differentiation defense response external side of plasma membrane humoral immune response negative regulation of interleukin-4 production plasma membrane positive regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of interleukin-10 production positive regulation of interleukin-2 production response to organic cyclic compound signal transduction	GO:0005886 GO:0006952 GO:0006959 GO:0007165 GO:0009897 GO:0014070 GO:0032713 GO:0032733 GO:0032743 GO:0043367 GO:0043372
GL_002343	Cation-independent mannose-6-phosphate receptor		Cation-independent mannose-6-phosphate receptor	P11717	1E6F 1GP0 1GP3 1GQB 1JPL 1JWG 1LF8 2CNJ 2L29 2L2A 2M68 2M6T 2V5N 2V5O 2V5P 5IEI 6N5X 6N5Y 6P8I 6V02 6Z30 6Z31 6Z32 8AFZ		Homo sapiens	9606		G protein-coupled receptor signaling pathway G-protein alpha-subunit binding Golgi apparatus Golgi membrane animal organ regeneration cell surface clathrin coat clathrin-coated endocytic vesicle membrane early endosome endocytic vesicle endosome endosome membrane enzyme binding extracellular exosome focal adhesion identical protein binding insulin-like growth factor II binding insulin-like growth factor binding insulin-like growth factor receptor activity late endosome liver development lysosomal transport mannose binding membrane nuclear envelope lumen perinuclear region of cytoplasm phosphoprotein binding plasma membrane positive regulation by host of viral process positive regulation of apoptotic process post-embryonic development receptor-mediated endocytosis response to retinoic acid response to tetrachloromethane retinoic acid binding retromer complex binding secretory granule membrane signal transduction signaling receptor activity spermatogenesis trans-Golgi network trans-Golgi network membrane trans-Golgi network transport vesicle transport vesicle	GO:0000139 GO:0001889 GO:0001965 GO:0001972 GO:0005010 GO:0005520 GO:0005537 GO:0005641 GO:0005768 GO:0005769 GO:0005770 GO:0005794 GO:0005802 GO:0005886 GO:0005925 GO:0006898 GO:0007041 GO:0007165 GO:0007186 GO:0007283 GO:0009791 GO:0009986 GO:0010008 GO:0016020 GO:0019899 GO:0030118 GO:0030133 GO:0030139 GO:0030140 GO:0030667 GO:0030669 GO:0031100 GO:0031995 GO:0032526 GO:0032588 GO:0038023 GO:0042802 GO:0043065 GO:0044794 GO:0048471 GO:0051219 GO:0070062 GO:1904772 GO:1905394
GL_000967	Protein eva-1 homolog C		Protein eva-1 homolog C	P58658			Homo sapiens	9606		carbohydrate binding heparin binding membrane	GO:0008201 GO:0016020 GO:0030246
GL_000393	Ficolin-3		Ficolin-3	O75636	2J5Z 2J60 2J64		Homo sapiens	9606		antigen binding blood microparticle carbohydrate binding carbohydrate derivative binding cell surface pattern recognition receptor signaling pathway collagen trimer collagen-containing extracellular matrix complement activation complement activation, lectin pathway defense response to virus external side of plasma membrane extracellular region extracellular space metal ion binding negative regulation of RNA biosynthetic process negative regulation of viral entry into host cell positive regulation of opsonization proteolysis recognition of apoptotic cell serine-type endopeptidase complex signaling receptor binding	GO:0001867 GO:0002752 GO:0003823 GO:0005102 GO:0005576 GO:0005581 GO:0005615 GO:0006508 GO:0006956 GO:0009897 GO:0030246 GO:0043654 GO:0046597 GO:0046872 GO:0051607 GO:0062023 GO:0072562 GO:0097367 GO:1902679 GO:1903028 GO:1905370
GL_000782	Myeloid cell surface antigen CD33		Myeloid cell surface antigen CD33	P20138	5IHB 5J06 5J0B 6D48 6D49 6D4A 6TL8 7AW6		Homo sapiens	9606		Golgi apparatus carbohydrate binding cell adhesion cell surface cell-cell adhesion cell-cell signaling external side of plasma membrane immune response-inhibiting signal transduction negative regulation of calcium ion transport negative regulation of cell population proliferation negative regulation of interleukin-1 beta production negative regulation of interleukin-8 production negative regulation of monocyte activation negative regulation of tumor necrosis factor production nucleoplasm peroxisome plasma membrane positive regulation of protein secretion positive regulation of protein tyrosine phosphatase activity protein phosphatase binding sialic acid binding signal transduction signaling receptor activity specific granule membrane tertiary granule membrane	GO:0002765 GO:0005654 GO:0005777 GO:0005794 GO:0005886 GO:0007155 GO:0007165 GO:0007267 GO:0008285 GO:0009897 GO:0009986 GO:0019903 GO:0030246 GO:0032691 GO:0032717 GO:0032720 GO:0033691 GO:0035579 GO:0038023 GO:0050714 GO:0051926 GO:0070821 GO:0098609 GO:0150102 GO:1903615
GL_001022	Pulmonary surfactant-associated protein D		Pulmonary surfactant-associated protein D	P35247	1B08 1M7L 1PW9 1PWB 2GGU 2GGX 2ORJ 2ORK 2OS9 2RIA 2RIB 2RIC 2RID 2RIE 3DBZ 3G81 3G83 3G84 3IKN 3IKP 3IKQ 3IKR 4E52 4M17 4M18 5OXR 5OXS		Homo sapiens	9606	1417 1452 1477	carbohydrate binding clathrin-coated endocytic vesicle collagen trimer defense response to bacterium endocytic vesicle endoplasmic reticulum membrane extracellular region extracellular space identical protein binding innate immune response lung alveolus development lysosome macrophage chemotaxis multivesicular body negative regulation of T cell proliferation negative regulation of interleukin-2 production positive regulation of phagocytosis reactive oxygen species metabolic process receptor-mediated endocytosis regulation of cytokine production respiratory gaseous exchange by respiratory system surfactant homeostasis	GO:0001817 GO:0005576 GO:0005581 GO:0005615 GO:0005764 GO:0005771 GO:0005789 GO:0006898 GO:0007585 GO:0030139 GO:0030246 GO:0032703 GO:0042130 GO:0042742 GO:0042802 GO:0043129 GO:0045087 GO:0045334 GO:0048246 GO:0048286 GO:0050766 GO:0072593
GL_001380	C-type lectin domain family 4 member M	DCSIGNR CRD Fc	DCSIGNR CRD Fc C-type lectin domain family 4 member M	Q9H2X3	1K9J 1SL6 1XAR 1XPH 3JQH	LfDB0278	Homo sapiens	9606		ICAM-3 receptor activity adaptive immune response antigen processing and presentation calcium-dependent protein binding carbohydrate binding cell-cell recognition cytoplasm external side of plasma membrane extracellular region host cell immune response innate immune response intracellular signal transduction intracellular transport of virus leukocyte cell-cell adhesion mannose binding membrane metal ion binding peptide antigen binding peptide antigen transport plasma membrane receptor-mediated endocytosis of virus by host cell receptor-mediated virion attachment to host cell signaling receptor activity viral entry into host cell viral genome replication virion attachment to host cell virion binding virus receptor activity	GO:0001618 GO:0002250 GO:0005537 GO:0005576 GO:0005737 GO:0005886 GO:0006955 GO:0007159 GO:0009897 GO:0009988 GO:0016020 GO:0019062 GO:0019065 GO:0019079 GO:0019882 GO:0030246 GO:0030369 GO:0035556 GO:0038023 GO:0042605 GO:0043657 GO:0045087 GO:0046718 GO:0046790 GO:0046813 GO:0046872 GO:0046968 GO:0048306 GO:0075733