GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin ▲	Lectin Name	Short Names	Lectin Name All	UniProt ID	PDB IDs	LfDB IDs	Monosaccharide Specificities	Species	Taxonomy ID	MCAW IDs	GO Labels	GO IDs
GL_002321	Leucoagglutinating phytohemagglutinin	PHA-L	PHA-L Leucoagglutinating phytohemagglutinin	P05087	1FAT 1G8W	LfDB0180	GalNAc	Phaseolus vulgaris	3885		defense response mannose binding toxin activity	GO:0005537 GO:0006952 GO:0090729
GL_002322	Erythroagglutinating phytohemagglutinin	PHA-E	PHA-E Erythroagglutinating phytohemagglutinin	P05088	3WCR 3WCS 3WOG 5AVA	LfDB0179	GalNAc	Phaseolus vulgaris	3885		defense response mannose binding toxin activity	GO:0005537 GO:0006952 GO:0090729
GL_002323	Intercellular adhesion molecule 1		Intercellular adhesion molecule 1	P05362	1D3E 1D3I 1D3L 1IAM 1IC1 1MQ8 1P53 1Z7Z 2OZ4 3TCX 5MZA 6EIT 6S8U 7BG7			Homo sapiens	9606		T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell T cell antigen processing and presentation T cell extravasation adhesion of symbiont to host cell adhesion cell adhesion mediated by integrin cell surface cellular response to amyloid-beta cellular response to glucose stimulus cellular response to leukemia inhibitory factor collagen-containing extracellular matrix establishment of endothelial barrier external side of plasma membrane extracellular exosome extracellular space focal adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules immunological synapse integrin binding leukocyte cell-cell adhesion leukocyte migration membrane membrane raft membrane to membrane docking negative regulation of endothelial cell apoptotic process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors plasma membrane positive regulation of ERK1 and ERK2 cascade positive regulation of cellular extravasation receptor-mediated virion attachment to host cell regulation of leukocyte mediated cytotoxicity regulation of ruffle assembly signaling receptor activity transmembrane signaling receptor activity virus receptor activity	GO:0001618 GO:0001772 GO:0001910 GO:0002291 GO:0002457 GO:0002693 GO:0004888 GO:0005178 GO:0005615 GO:0005886 GO:0005925 GO:0007155 GO:0007157 GO:0007159 GO:0009897 GO:0009986 GO:0016020 GO:0022614 GO:0033627 GO:0038023 GO:0044406 GO:0045121 GO:0046813 GO:0050900 GO:0061028 GO:0062023 GO:0070062 GO:0070374 GO:0071333 GO:0072683 GO:1900027 GO:1902042 GO:1904646 GO:1990830 GO:2000352
GL_002324	C-reactive protein 1.1		C-reactive protein 1.1	P06205				Limulus polyphemus	6850		extracellular region metal ion binding	GO:0005576 GO:0046872
GL_002325	T-cell surface antigen CD2		T-cell surface antigen CD2	P06729	1CDB 1GYA 1HNF 1L2Z 1QA9 2J6O 2J7I			Homo sapiens	9606		Golgi apparatus T cell activation apoptotic process cell surface cell surface receptor signaling pathway cell-cell adhesion cell-cell junction cytoplasmic side of plasma membrane external side of plasma membrane extracellular region heterotypic cell-cell adhesion identical protein binding membrane raft polarization natural killer cell activation natural killer cell mediated cytotoxicity nucleoplasm plasma membrane positive regulation of interleukin-8 production positive regulation of myeloid dendritic cell activation positive regulation of tumor necrosis factor production positive regulation of type II interferon production protein self-association protein-containing complex receptor tyrosine kinase binding regulation of T cell differentiation signaling receptor activity signaling receptor binding	GO:0001766 GO:0005102 GO:0005576 GO:0005654 GO:0005794 GO:0005886 GO:0005911 GO:0006915 GO:0007166 GO:0009897 GO:0009898 GO:0009986 GO:0030101 GO:0030887 GO:0030971 GO:0032729 GO:0032757 GO:0032760 GO:0032991 GO:0034113 GO:0038023 GO:0042110 GO:0042267 GO:0042802 GO:0043621 GO:0045580 GO:0098609
GL_002326	Cation-independent mannose-6-phosphate receptor		Cation-independent mannose-6-phosphate receptor	P08169	1Q25 1SYO 1SZ0 2KVA 2KVB 6UM1 6UM2			Bos taurus	9913		Golgi apparatus Golgi membrane cell surface endocytic vesicle endosome membrane insulin-like growth factor binding kringle domain binding late endosome lysosomal transport mannose binding phosphoprotein binding plasma membrane signaling receptor activity trans-Golgi network	GO:0000139 GO:0005520 GO:0005537 GO:0005770 GO:0005794 GO:0005802 GO:0005886 GO:0007041 GO:0009986 GO:0010008 GO:0030139 GO:0036143 GO:0038023 GO:0051219
GL_002327	Type 1 fimbrin D-mannose specific adhesin		Type 1 fimbrin D-mannose specific adhesin	P08191	1KIU 1KLF 1QUN 1TR7 1UWF 1ZE3 2VCO 3RFZ 3ZL1 3ZL2 4ATT 4AUJ 4AUU 4AUY 4AV0 4AV4 4AV5 4AVH 4AVI 4AVJ 4AVK 4CSS 4CST 4J3O 4LOV 4X50 4X5P 4X5Q 4X5R 4XO8 4XO9 4XOA 4XOB 4XOD 5ABZ 5CGB 5F2F 5F3F 5FS5 5FWR 5FX3 5JCQ 5JCR 5L4T 5L4U 5L4V 5L4W 5L4X 5L4Y 5MCA 5MTS 5MUC 6E14 6E15 6G2R 6G2S 6GTX 6GTY 6YHW 7AYN 7BHD 7SZO 8BVD 8BXY 8BY3			Escherichia coli K-12	83333	1890 2517 2518 2520	cell adhesion cell adhesion involved in single-species biofilm formation cell-substrate adhesion host cell membrane mannose binding mechanosensory behavior pilus pilus tip	GO:0005537 GO:0007155 GO:0007638 GO:0009289 GO:0009419 GO:0031589 GO:0033644 GO:0043709
GL_002328	Hemagglutinin glycoprotein		Hemagglutinin glycoprotein	P08362	2RKC 2ZB5 2ZB6 3ALW 3ALX 3ALZ 3INB			Measles virus strain Edmonston	11235		host cell plasma membrane host cell surface receptor binding membrane viral entry into host cell viral envelope virion attachment to host cell virion membrane	GO:0016020 GO:0019031 GO:0019062 GO:0020002 GO:0046718 GO:0046789 GO:0055036
GL_002329	Mannose-binding protein C		Mannose-binding protein C	P08661	1BV4 1KZA 1KZB 1KZC 1KZD 1KZE 1RDI 1RDJ 1RDK 1RDL 1RDM 1RDN 1RDO			Rattus norvegicus	10116		antiviral innate immune response calcium ion binding calcium-dependent protein binding cell surface pattern recognition receptor signaling pathway collagen trimer complement activation, classical pathway complement activation, lectin pathway defense response to Gram-positive bacterium extracellular space galactose binding identical protein binding innate immune response killing by host of symbiont cells mannose binding multivesicular body negative regulation of viral process phosphatidylinositol-4-phosphate binding positive regulation of complement activation positive regulation of opsonization positive regulation of phagocytosis positive regulation of protein processing protease binding protein self-association protein-containing complex proteolysis serine-type endopeptidase complex signaling receptor binding surfactant homeostasis	GO:0001867 GO:0002020 GO:0002752 GO:0005102 GO:0005509 GO:0005534 GO:0005537 GO:0005581 GO:0005615 GO:0005771 GO:0006508 GO:0006958 GO:0010954 GO:0032991 GO:0042802 GO:0043129 GO:0043621 GO:0045087 GO:0045917 GO:0048306 GO:0048525 GO:0050766 GO:0050830 GO:0051873 GO:0070273 GO:0140374 GO:1903028 GO:1905370
GL_002330	Shiga-like toxin 2 subunit B		Shiga-like toxin 2 subunit B	P09386	1R4P 2GA4 6FE4 7UJJ			Escherichia phage 933W	10730		extracellular region hemolysis by symbiont of host erythrocytes modulation of host virulence by virus toxin activity	GO:0005576 GO:0019836 GO:0090729 GO:0098676