GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	Lectin Name All	UniProt ID	PDB IDs	Species	Taxonomy ID ▼	MCAW IDs	GO Labels	GO IDs
GL_001665	Interleukin-2	Interleukin-2	P04351	4YQX 4YUE	Mus musculus	10090		G protein-coupled receptor signaling pathway T cell proliferation activated T cell proliferation adaptive immune response carbohydrate binding cytokine activity extracellular space extrinsic apoptotic signaling pathway in absence of ligand gene expression glycosphingolipid binding growth factor activity interleukin-2 receptor binding interleukin-2-mediated signaling pathway kappa-type opioid receptor binding leukocyte activation involved in immune response lymphocyte proliferation negative regulation of B cell apoptotic process negative regulation of T-helper 17 cell differentiation negative regulation of inflammatory response negative regulation of lymphocyte proliferation negative regulation of protein phosphorylation positive regulation of B cell proliferation positive regulation of T cell differentiation positive regulation of T cell proliferation positive regulation of activated T cell proliferation positive regulation of cytosolic calcium ion concentration positive regulation of dendritic spine development positive regulation of immunoglobulin production positive regulation of interleukin-17 production positive regulation of isotype switching to IgG isotypes positive regulation of plasma cell differentiation positive regulation of protein phosphorylation positive regulation of regulatory T cell differentiation positive regulation of transcription by RNA polymerase II positive regulation of type II interferon production positive regulation of tyrosine phosphorylation of STAT protein protein kinase C-activating G protein-coupled receptor signaling pathway regulation of CD4-positive, alpha-beta T cell proliferation regulation of T cell homeostatic proliferation response to ethanol transcription by RNA polymerase II	GO:0001933 GO:0001934 GO:0002250 GO:0002366 GO:0002639 GO:0002903 GO:0005125 GO:0005134 GO:0005615 GO:0006366 GO:0007186 GO:0007204 GO:0007205 GO:0008083 GO:0010467 GO:0030246 GO:0030890 GO:0031851 GO:0032729 GO:0032740 GO:0038110 GO:0042098 GO:0042102 GO:0042104 GO:0042531 GO:0043208 GO:0045471 GO:0045582 GO:0045591 GO:0045944 GO:0046013 GO:0046651 GO:0048304 GO:0050672 GO:0050728 GO:0050798 GO:0060999 GO:0097192 GO:1900100 GO:2000320 GO:2000561
GL_002056	Protein ERGIC-53-like	Protein ERGIC-53-like	Q8VCD3		Mus musculus	10090		COPII-coated ER to Golgi transport vesicle Golgi membrane endoplasmic reticulum membrane endoplasmic reticulum to Golgi vesicle-mediated transport endoplasmic reticulum-Golgi intermediate compartment endoplasmic reticulum-Golgi intermediate compartment membrane mannose binding	GO:0000139 GO:0005537 GO:0005789 GO:0005793 GO:0006888 GO:0030134 GO:0033116
GL_002044	Macrophage mannose receptor 1	Macrophage mannose receptor 1	Q61830	1DQG 1DQO 1FWU 1FWV	Mus musculus	10090		cargo receptor activity cell surface cellular response to interleukin-4 cellular response to lipopolysaccharide cellular response to type II interferon endosome membrane mannose binding plasma membrane receptor-mediated endocytosis signaling receptor activity transmembrane signaling receptor activity	GO:0004888 GO:0005537 GO:0005886 GO:0006898 GO:0009986 GO:0010008 GO:0038023 GO:0038024 GO:0071222 GO:0071346 GO:0071353
GL_000186	C-type lectin domain family 4 member G	C-type lectin domain family 4 member G	Q8BNX1		Mus musculus	10090	3104 3133	T cell mediated immunity alpha-beta T cell proliferation carbohydrate binding carbohydrate derivative binding external side of plasma membrane fructose binding immature T cell proliferation in thymus immune response mannose binding negative regulation of T cell mediated immunity negative regulation of T cell proliferation negative regulation of alpha-beta T cell proliferation negative regulation of immature T cell proliferation in thymus plasma membrane polysaccharide binding positive regulation of viral life cycle viral entry into host cell virus coreceptor activity virus receptor activity	GO:0001618 GO:0002456 GO:0002710 GO:0005537 GO:0005886 GO:0006955 GO:0009897 GO:0030246 GO:0030247 GO:0033080 GO:0033088 GO:0042130 GO:0046633 GO:0046642 GO:0046718 GO:0070061 GO:0097367 GO:0120274 GO:1903902
GL_000505	Galectin-6	Galectin-6	O54891		Mus musculus	10090		antibacterial peptide biosynthetic process carbohydrate binding defense response to bacterium	GO:0002780 GO:0030246 GO:0042742
GL_000981	Protein FAM3D	Protein FAM3D	P97805		Mus musculus	10090		carbohydrate binding extracellular space negative regulation of insulin secretion	GO:0005615 GO:0030246 GO:0046676
GL_000966	Protein eva-1 homolog C	Protein eva-1 homolog C	P58659		Mus musculus	10090		carbohydrate binding heparin binding plasma membrane	GO:0005886 GO:0008201 GO:0030246
GL_001637	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1	P47856		Mus musculus	10090		UDP-N-acetylglucosamine biosynthetic process UDP-N-acetylglucosamine metabolic process amino acid binding carbohydrate binding carbohydrate derivative binding circadian regulation of gene expression fructose 6-phosphate metabolic process glucosamine biosynthetic process glutamine metabolic process glutamine-fructose-6-phosphate transaminase (isomerizing) activity identical protein binding negative regulation of glycogen biosynthetic process protein N-linked glycosylation	GO:0004360 GO:0006002 GO:0006042 GO:0006047 GO:0006048 GO:0006487 GO:0006541 GO:0016597 GO:0030246 GO:0032922 GO:0042802 GO:0045719 GO:0097367
GL_001825	Ribose-phosphate pyrophosphokinase 2	Ribose-phosphate pyrophosphokinase 2	Q9CS42		Mus musculus	10090		5-phosphoribose 1-diphosphate biosynthetic process ADP binding AMP binding AMP biosynthetic process ATP binding GDP binding carbohydrate binding cytoplasm cytosol identical protein binding kinase activity magnesium ion binding pentose-phosphate shunt phosphorylation protein homodimerization activity protein-containing complex purine nucleotide biosynthetic process ribose phosphate diphosphokinase activity ribose phosphate diphosphokinase complex	GO:0000287 GO:0002189 GO:0004749 GO:0005524 GO:0005737 GO:0005829 GO:0006015 GO:0006098 GO:0006164 GO:0006167 GO:0016208 GO:0016301 GO:0016310 GO:0019003 GO:0030246 GO:0032991 GO:0042802 GO:0042803 GO:0043531
GL_000162	C-type lectin domain family 2 member F	C-type lectin domain family 2 member F	Q8VI21		Mus musculus	10090		carbohydrate binding cell surface endoplasmic reticulum external side of plasma membrane natural killer cell lectin-like receptor binding plasma membrane protein homodimerization activity	GO:0005783 GO:0005886 GO:0009897 GO:0009986 GO:0030246 GO:0042803 GO:0046703