GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	Lectin Name All	UniProt ID ▲	PDB IDs	Species	Taxonomy ID	MCAW IDs	GO Labels	GO IDs
GL_000153	C-type lectin domain family 2 member D	C-type lectin domain family 2 member D	Q9UHP7	4QKG 4QKH 4QKI 4QKJ 4WCO 5MGT	Homo sapiens	9606		carbohydrate binding cell surface cell surface receptor signaling pathway endoplasmic reticulum external side of plasma membrane membrane plasma membrane transmembrane signaling receptor activity	GO:0004888 GO:0005783 GO:0005886 GO:0007166 GO:0009897 GO:0009986 GO:0016020 GO:0030246
GL_000466	Galactoside-binding soluble lectin 13	Galactoside-binding soluble lectin 13	Q9UHV8	5XG7 5XG8 5Y03 6A62 6A63 6A64 6A65 6A66 6KJW 6KJX 6KJY	Homo sapiens	9606		apoptotic process carbohydrate binding cytoplasm lysophospholipase activity nuclear body nuclear matrix nucleoplasm phospholipid metabolic process	GO:0004622 GO:0005654 GO:0005737 GO:0006644 GO:0006915 GO:0016363 GO:0016604 GO:0030246
GL_000189	C-type lectin domain family 4 member K	C-type lectin domain family 4 member K	Q9UJ71	3C22 3KQG 3P5D 3P5E 3P5F 3P5G 3P5H 3P5I 3P7F 3P7G 3P7H 4AK8 4N32 4N33 4N34 4N35 4N36 4N37 4N38 5G6U 7WZ8 7YTQ	Homo sapiens	9606	1842 5090	carbohydrate binding clathrin-coated endocytic vesicle membrane defense response to virus early endosome membrane endocytic vesicle external side of plasma membrane mannose binding plasma membrane	GO:0005537 GO:0005886 GO:0009897 GO:0030139 GO:0030246 GO:0030669 GO:0031901 GO:0051607
GL_000373	F-box only protein 2	F-box only protein 2	Q9UK22		Homo sapiens	9606		SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process amyloid-beta binding carbohydrate binding cytoplasm cytosol denatured protein binding dendritic spine endoplasmic reticulum extrinsic component of postsynaptic membrane glutamatergic synapse glycoprotein catabolic process negative regulation of cell population proliferation protein modification process protein ubiquitination proteolysis regulation of protein catabolic process at postsynapse, modulating synaptic transmission regulation of protein ubiquitination ubiquitin-dependent ERAD pathway ubiquitin-protein transferase activity	GO:0001540 GO:0004842 GO:0005737 GO:0005783 GO:0005829 GO:0006508 GO:0006516 GO:0008285 GO:0016567 GO:0019005 GO:0030246 GO:0030433 GO:0031146 GO:0031249 GO:0031396 GO:0036211 GO:0043197 GO:0098890 GO:0098978 GO:0099576
GL_002410	Paired immunoglobulin-like type 2 receptor beta	Paired immunoglobulin-like type 2 receptor beta	Q9UKJ0	4NFC 4NFD	Homo sapiens	9606		MHC class I protein binding activation of transmembrane receptor protein tyrosine kinase activity plasma membrane transmembrane receptor protein tyrosine kinase signaling pathway	GO:0005886 GO:0007169 GO:0007171 GO:0042288
GL_002411	Paired immunoglobulin-like type 2 receptor alpha	Paired immunoglobulin-like type 2 receptor alpha	Q9UKJ1	3WUZ 3WV0 4NFB 5XO2 5XOF	Homo sapiens	9606		MHC class I protein binding extracellular exosome plasma membrane signal transduction	GO:0005886 GO:0007165 GO:0042288 GO:0070062
GL_000180	C-type lectin domain family 4 member E	C-type lectin domain family 4 member E	Q9ULY5	3WH2 3WH3	Homo sapiens	9606		Fc-gamma receptor signaling pathway T cell differentiation involved in immune response antifungal innate immune response calcium ion binding carbohydrate binding cell projection defense response to bacterium external side of plasma membrane glycolipid binding innate immune response membrane pattern recognition receptor activity pattern recognition receptor signaling pathway phagocytic cup phagocytic vesicle membrane plasma membrane positive regulation of cytokine production	GO:0001819 GO:0001891 GO:0002221 GO:0002292 GO:0005509 GO:0005886 GO:0009897 GO:0016020 GO:0030246 GO:0030670 GO:0038094 GO:0038187 GO:0042742 GO:0042995 GO:0045087 GO:0051861 GO:0061760
GL_000174	C-type lectin domain family 4 member A	C-type lectin domain family 4 member A	Q9UMR7	5B1W 5B1X	Homo sapiens	9606		CD8-positive, alpha-beta T cell activation adaptive immune response antifungal innate immune response antigen processing and presentation of exogenous peptide antigen via MHC class I calcium ion binding carbohydrate binding cell adhesion cell surface receptor signaling pathway external side of plasma membrane mannose binding negative regulation of cytokine production negative regulation of tumor necrosis factor production plasma membrane plasmacytoid dendritic cell antigen processing and presentation transmembrane signaling receptor activity	GO:0001818 GO:0002250 GO:0002470 GO:0004888 GO:0005509 GO:0005537 GO:0005886 GO:0007155 GO:0007166 GO:0009897 GO:0030246 GO:0032720 GO:0036037 GO:0042590 GO:0061760
GL_001870	Uncharacterized family 31 glucosidase C1039.11c	Uncharacterized family 31 glucosidase C1039.11c	Q9URX4		Schizosaccharomyces pombe 972h-	284812		alpha-glucosidase activity carbohydrate binding carbohydrate catabolic process endoplasmic reticulum hydrolase activity, hydrolyzing O-glycosyl compounds spore wall	GO:0004553 GO:0005783 GO:0016052 GO:0030246 GO:0031160 GO:0090599
GL_001062	Putative zinc metalloproteinase C607.06c	Putative zinc metalloproteinase C607.06c	Q9US12		Schizosaccharomyces pombe 972h-	284812		carbohydrate binding cell division site cytosol metal ion binding metallopeptidase activity nucleus proteolysis	GO:0005634 GO:0005829 GO:0006508 GO:0008237 GO:0030246 GO:0032153 GO:0046872