GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	Lectin Name All	UniProt ID ▲	PDB IDs	Species	Taxonomy ID	GO Labels	GO IDs
GL_002412	Hemagglutinin	Hemagglutinin	Q9WFX3	1RD8 1RUZ 2WRG 3GBN 3LZF 3R2X 4EEF 4GXU 4GXX 4JUG 4JUH 4JUJ 4PY8 5VMG 5VMJ	Influenza A virus (A/Brevig Mission/1/1918(H1N1))	88776	clathrin-dependent endocytosis of virus by host cell fusion of virus membrane with host endosome membrane fusion of virus membrane with host plasma membrane host cell plasma membrane host cell surface receptor binding membrane viral budding from plasma membrane viral envelope virion attachment to host cell virion membrane	GO:0016020 GO:0019031 GO:0019062 GO:0019064 GO:0020002 GO:0039654 GO:0046761 GO:0046789 GO:0055036 GO:0075512
GL_000387	Ficolin-1	Ficolin-1	Q9WTS8		Rattus norvegicus	10116	G protein-coupled receptor signaling pathway antigen binding carbohydrate binding carbohydrate derivative binding cell surface pattern recognition receptor signaling pathway collagen trimer collagen-containing extracellular matrix complement activation, lectin pathway extracellular space metal ion binding pattern recognition receptor activity plasma membrane positive regulation of interleukin-8 production signaling receptor binding	GO:0001867 GO:0002752 GO:0003823 GO:0005102 GO:0005581 GO:0005615 GO:0005886 GO:0007186 GO:0030246 GO:0032757 GO:0038187 GO:0046872 GO:0062023 GO:0097367
GL_000313	Chitinase-3-like protein 1	Chitinase-3-like protein 1	Q9WTV1		Rattus norvegicus	10116	activation of NF-kappaB-inducing kinase activity apoptotic process carbohydrate binding carbohydrate metabolic process cellular response to interleukin-1 cellular response to tumor necrosis factor chitin binding chitin catabolic process cytoplasm endoplasmic reticulum extracellular region extracellular space inflammatory response lung development perinuclear region of cytoplasm positive regulation of ERK1 and ERK2 cascade positive regulation of angiogenesis positive regulation of interleukin-8 production positive regulation of peptidyl-threonine phosphorylation positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction response to interleukin-1 response to interleukin-6 response to mechanical stimulus response to tumor necrosis factor	GO:0005576 GO:0005615 GO:0005737 GO:0005783 GO:0005975 GO:0006032 GO:0006915 GO:0006954 GO:0007250 GO:0008061 GO:0009612 GO:0010800 GO:0030246 GO:0030324 GO:0032757 GO:0034612 GO:0045766 GO:0048471 GO:0051897 GO:0070374 GO:0070555 GO:0070741 GO:0071347 GO:0071356
GL_000072	Attractin	Attractin	Q9WU60		Mus musculus	10090	carbohydrate binding cerebellum development chromatin binding cytoplasm extracellular space inflammatory response myelination pigmentation plasma membrane regulation of multicellular organism growth response to oxidative stress signaling receptor activity	GO:0003682 GO:0005615 GO:0005737 GO:0005886 GO:0006954 GO:0006979 GO:0021549 GO:0030246 GO:0038023 GO:0040014 GO:0042552 GO:0043473
GL_001680	Laforin	Laforin	Q9WUA5		Mus musculus	10090	L-glutamate transmembrane transport Wnt signaling pathway autophagosome assembly autophagy calcium ion transport carbohydrate binding carbohydrate phosphatase activity carbohydrate phosphorylation cytoplasm cytoplasmic side of endoplasmic reticulum membrane cytoplasmic side of rough endoplasmic reticulum membrane cytosol dendrite dephosphorylation glial cell proliferation glycogen (starch) synthase activity glycogen binding glycogen biosynthetic process glycogen metabolic process habituation identical protein binding macromolecule metabolic process mitochondrion organization myosin phosphatase activity negative regulation of TOR signaling negative regulation of cell cycle negative regulation of dephosphorylation negative regulation of gene expression negative regulation of peptidyl-serine phosphorylation nervous system development nucleoplasm nucleus perikaryon phosphatase activity phosphoprotein phosphatase activity plasma membrane polysaccharide binding polysome positive regulation of macroautophagy proteasome-mediated ubiquitin-dependent protein catabolic process protein dimerization activity protein homodimerization activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activity protein tyrosine/serine/threonine phosphatase activity regulation of cell growth regulation of gene expression regulation of phosphorylation regulation of proteasomal protein catabolic process regulation of protein import into nucleus regulation of protein localization to plasma membrane regulation of protein phosphorylation regulation of protein ubiquitination starch binding	GO:0000045 GO:0001558 GO:0001932 GO:0004373 GO:0004721 GO:0004722 GO:0004725 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005844 GO:0005886 GO:0005977 GO:0005978 GO:0006816 GO:0006914 GO:0007005 GO:0007399 GO:0008138 GO:0010468 GO:0010629 GO:0014009 GO:0015813 GO:0016055 GO:0016239 GO:0016311 GO:0016791 GO:0017018 GO:0019203 GO:0030246 GO:0030247 GO:0030425 GO:0031396 GO:0032007 GO:0033137 GO:0035305 GO:0042306 GO:0042325 GO:0042802 GO:0042803 GO:0043161 GO:0043170 GO:0043204 GO:0045786 GO:0046835 GO:0046959 GO:0046983 GO:0061136 GO:0098554 GO:0098556 GO:1903076 GO:2001069 GO:2001070
GL_001644	Glycogen phosphorylase, muscle form	Glycogen phosphorylase, muscle form	Q9WUB3		Mus musculus	10090	AMP binding SHG alpha-glucan phosphorylase activity Z disc carbohydrate binding cytoplasm glycogen catabolic process glycogen metabolic process glycogen phosphorylase activity intracellular calcium ion homeostasis linear malto-oligosaccharide phosphorylase activity organic cyclic compound binding pyridoxal phosphate binding response to cAMP response to hypoxia response to organic substance sarcoplasmic reticulum	GO:0001666 GO:0005737 GO:0005977 GO:0005980 GO:0006874 GO:0008184 GO:0010033 GO:0016208 GO:0016529 GO:0030018 GO:0030170 GO:0030246 GO:0051591 GO:0097159 GO:0102250 GO:0102499
GL_000165	C-type lectin domain family 2 member I	C-type lectin domain family 2 member I	Q9WVF9	3RS1	Mus musculus	10090	T cell receptor signaling pathway carbohydrate binding cell surface endoplasmic reticulum external side of plasma membrane membrane raft assembly natural killer cell lectin-like receptor binding negative regulation of osteoclast differentiation positive regulation of immunological synapse formation receptor clustering regulation of T cell proliferation regulation of actin filament polymerization regulation of interleukin-2 production transmembrane signaling receptor activity	GO:0001765 GO:0004888 GO:0005783 GO:0009897 GO:0009986 GO:0030246 GO:0030833 GO:0032663 GO:0042129 GO:0043113 GO:0045671 GO:0046703 GO:0050852 GO:2000522
GL_000282	Calreticulin	Calreticulin	Q9XF98		Prunus armeniaca	36596	calcium ion binding carbohydrate binding endoplasmic reticulum lumen protein folding unfolded protein binding	GO:0005509 GO:0005788 GO:0006457 GO:0030246 GO:0051082
GL_000417	G-type lectin S-receptor-like serine/threonine-protein kinase At1g34300	G-type lectin S-receptor-like serine/threonine-protein kinase At1g34300	Q9XID3		Arabidopsis thaliana	3702	ATP binding calmodulin binding carbohydrate binding phosphorylation plasma membrane protein serine kinase activity protein serine/threonine kinase activity recognition of pollen ubiquitin protein ligase binding	GO:0004674 GO:0005516 GO:0005524 GO:0005886 GO:0016310 GO:0030246 GO:0031625 GO:0048544 GO:0106310
GL_002413	Tail spike protein	Tail spike protein	Q9XJP3	2VBE 2VBK 2VBM 4URR 7SG7	Lederbergvirus Sf6	10761	disruption by virus of host envelope lipopolysaccharide during virus entry disruption of host cell envelope during viral entry endo-1,3-alpha-L-rhamnosidase activity entry into host metabolic process virion attachment to host cell virus tail, fiber	GO:0008152 GO:0019062 GO:0044409 GO:0052775 GO:0098024 GO:0098994 GO:0098995