GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	Short Names	Lectin Name All	UniProt ID	PDB IDs	LfDB IDs	Monosaccharide Specificities	Species	Taxonomy ID	MCAW IDs ▲	GO Labels	GO IDs
GL_000384	Ficolin-1		Ficolin-1	O00602	2D39 2JHH 2JHI 2JHK 2JHL 2JHM 2WNP			Homo sapiens	9606	3259 3262 3264	G protein-coupled receptor binding G protein-coupled receptor signaling pathway antigen binding carbohydrate binding carbohydrate derivative binding cell surface pattern recognition receptor signaling pathway collagen trimer collagen-containing extracellular matrix complement activation, lectin pathway external side of plasma membrane extracellular region extracellular space ficolin-1-rich granule lumen metal ion binding negative regulation of viral entry into host cell pattern recognition receptor activity plasma membrane positive regulation of interleukin-8 production positive regulation of opsonization protein localization to cell surface proteolysis recognition of apoptotic cell secretory granule lumen serine-type endopeptidase complex sialic acid binding signaling receptor binding	GO:0001664 GO:0001867 GO:0002752 GO:0003823 GO:0005102 GO:0005576 GO:0005581 GO:0005615 GO:0005886 GO:0006508 GO:0007186 GO:0009897 GO:0030246 GO:0032757 GO:0033691 GO:0034394 GO:0034774 GO:0038187 GO:0043654 GO:0046597 GO:0046872 GO:0062023 GO:0097367 GO:1903028 GO:1904813 GO:1905370
GL_000509	Galectin-8	Galectin-8	Galectin-8 Galectin-8	O00214	2YRO 2YV8 2YXS 3AP4 3AP5 3AP6 3AP7 3AP9 3APB 3OJB 3VKL 3VKM 3VKN 3VKO 4BMB 4BME 4FQZ 4GXL 4HAN 5GZC 5GZD 5GZE 5GZF 5GZG 5T7I 5T7S 5T7T 5T7U 5VWG 6W4Z 6Z6Y 7AEN 7ALS 7P1M 8HL9	LfDB0273		Homo sapiens	9606	4565	carbohydrate binding cellular response to virus cytoplasm cytoplasmic vesicle cytosol extracellular space integrin binding lymphatic endothelial cell migration membrane xenophagy	GO:0005178 GO:0005615 GO:0005737 GO:0005829 GO:0016020 GO:0030246 GO:0031410 GO:0098586 GO:0098792 GO:1904977
GL_000187	C-type lectin domain family 4 member G		C-type lectin domain family 4 member G	Q6UXB4				Homo sapiens	9606	4587 4590 4596	T cell mediated immunity alpha-beta T cell proliferation carbohydrate binding carbohydrate derivative binding external side of plasma membrane fructose binding glycosylated region protein binding immature T cell proliferation in thymus immune response mannose binding negative regulation of T cell mediated immunity negative regulation of alpha-beta T cell proliferation negative regulation of immature T cell proliferation in thymus plasma membrane polysaccharide binding positive regulation of viral life cycle viral entry into host cell virus coreceptor activity virus receptor activity	GO:0001618 GO:0002456 GO:0002710 GO:0005537 GO:0005886 GO:0006955 GO:0009897 GO:0030246 GO:0030247 GO:0033080 GO:0033088 GO:0046633 GO:0046642 GO:0046718 GO:0070061 GO:0097367 GO:0120274 GO:0140081 GO:1903902
GL_000499	Galectin-4		Galectin-4	Q8K419	2DYC 3I8T			Mus musculus	10090	467	antibacterial peptide biosynthetic process carbohydrate binding collagen-containing extracellular matrix defense response to bacterium extracellular space galactoside binding	GO:0002780 GO:0005615 GO:0016936 GO:0030246 GO:0042742 GO:0062023
GL_002007	E-selectin		E-selectin	Q00690				Mus musculus	10090	4832	actin filament-based process calcium ion binding caveola clathrin-coated pit cortical cytoskeleton external side of plasma membrane extracellular space heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules leukocyte cell-cell adhesion leukocyte migration leukocyte tethering or rolling membrane raft oligosaccharide binding perinuclear region of cytoplasm phospholipase binding plasma membrane positive regulation of leukocyte migration positive regulation of leukocyte tethering or rolling positive regulation of receptor internalization response to cytokine response to interleukin-1 sialic acid binding transmembrane signaling receptor activity	GO:0002092 GO:0002687 GO:0004888 GO:0005509 GO:0005615 GO:0005886 GO:0005901 GO:0005905 GO:0007157 GO:0007159 GO:0009897 GO:0030029 GO:0030863 GO:0033691 GO:0034097 GO:0043274 GO:0045121 GO:0048471 GO:0050900 GO:0050901 GO:0070492 GO:0070555 GO:1903238
GL_000060	Anti-H(O) lectin 1	UEA I	UEA I Anti-H(O) lectin 1	P22972	1FX5 1JXN	LfDB0185	Fuc	Ulex europaeus	3902	4878 4879 4880	carbohydrate binding metal ion binding	GO:0030246 GO:0046872
GL_000487	Galectin-2	Galectin-2 (Human)	Galectin-2 (Human) Galectin-2	P05162	1HLC 5DG1 5DG2 5EWS	LfDB0055	Gal	Homo sapiens	9606	5110	T cell homeostasis carbohydrate binding cell-cell adhesion galactoside binding galectin complex positive regulation of apoptotic process positive regulation of inflammatory response	GO:0016936 GO:0030246 GO:0043029 GO:0043065 GO:0050729 GO:0098609 GO:1990724
GL_002319	Tetanus toxin		Tetanus toxin	P04958	1A8D 1AF9 1D0H 1DFQ 1DIW 1DLL 1FV2 1FV3 1YVG 1YXW 1YYN 1Z7H 3HMY 3HN1 4J1L 5N0B 5N0C 7BXX 7BY4 7BY5 7OH0 7OH1			Clostridium tetani E88	212717	5164	clathrin-coated endocytic vesicle membrane cytosol endocytic vesicle membrane extracellular region metalloendopeptidase activity modulation by symbiont of host neurotransmitter secretion plasma membrane protein transmembrane transporter activity proteolysis toxin activity zinc ion binding	GO:0004222 GO:0005576 GO:0005829 GO:0005886 GO:0006508 GO:0008270 GO:0008320 GO:0030666 GO:0030669 GO:0044079 GO:0090729
GL_000501	Galectin-4	Galectin-4	Galectin-4 Galectin-4	P56470	1X50 4XZP 4YLZ 4YM0 4YM1 4YM2 4YM3 5CBL 5DUU 5DUV 5DUW 5DUX 6WAB	LfDB0272		Homo sapiens	9606	523	antibacterial peptide biosynthetic process carbohydrate binding cell adhesion collagen-containing extracellular matrix cytosol extracellular space galactoside binding plasma membrane	GO:0002780 GO:0005615 GO:0005829 GO:0005886 GO:0007155 GO:0016936 GO:0030246 GO:0062023
GL_002220	Hemagglutinin		Hemagglutinin	Q5EP31	4BH2 4BH3 4BH4 4N5Z 6CFG			Influenza A virus (A/Viet Nam/1203/2004(H5N1))	284218	5235 5236 5238 5245 5246 5262 5263 5269 5272 5277 5282 5284	apical plasma membrane clathrin-dependent endocytosis of virus by host cell fusion of virus membrane with host endosome membrane fusion of virus membrane with host plasma membrane host cell plasma membrane host cell surface receptor binding viral budding from plasma membrane viral envelope virion attachment to host cell virion membrane	GO:0016324 GO:0019031 GO:0019062 GO:0019064 GO:0020002 GO:0039654 GO:0046761 GO:0046789 GO:0055036 GO:0075512