GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	Short Names	Lectin Name All	UniProt ID	PDB IDs	LfDB IDs	Monosaccharide Specificities	Species	Taxonomy ID	MCAW IDs ▲	GO Labels	GO IDs
GL_002303	Concanavalin-A	ConA	ConA Concanavalin-A	P02866	1APN 1BXH 1C57 1CES 1CJP 1CN1 1CON 1CVN 1DQ0 1DQ1 1DQ2 1DQ4 1DQ5 1DQ6 1ENQ 1ENR 1ENS 1GIC 1GKB 1HQW 1I3H 1JBC 1JN2 1JOJ 1JUI 1JW6 1JYC 1JYI 1NLS 1NXD 1ONA 1QGL 1QNY 1SCR 1SCS 1TEI 1VAL 1VAM 1XQN 2CNA 2CTV 2ENR 2UU8 2YZ4 3CNA 3D4K 3ENR 3NWK 4P9W 4P9X 4P9Y 4PF5 5CNA 5O6N 5WEY 5Z5L 5Z5N 5Z5P 5Z5Y 5ZAC 6AHG 6H2M 6XT6 7MG1 7MG2 7MG3 7MG4 7MG5 7MG6 7MG7 7MG8 7MG9 7MGA 7MGB 7MGC 7MGD	LfDB0170	Glc Man	Canavalia ensiformis	3823	5342	defense response mannose binding metal ion binding regulation of defense response to virus	GO:0005537 GO:0006952 GO:0046872 GO:0050688
GL_002355	Mannose-binding protein A		Mannose-binding protein A	P19999	1AFA 1AFB 1AFD 1BCH 1BCJ 1BUU 1FIF 1FIH 1KMB 1KWT 1KWU 1KWV 1KWW 1KWX 1KWY 1KWZ 1KX0 1KX1 1MSB 1RTM 1YTT 2KMB 2MSB 3KMB 4KMB			Rattus norvegicus	10116	5397	calcium ion binding calcium-dependent carbohydrate binding calcium-dependent protein binding collagen trimer complement activation, classical pathway complement activation, lectin pathway defense response to Gram-positive bacterium extracellular space identical protein binding killing by host of symbiont cells mannose binding multivesicular body oligosaccharide binding phosphatidylinositol-4-phosphate binding polysaccharide binding positive regulation of phagocytosis protease binding protein homodimerization activity protein homotrimerization surfactant homeostasis	GO:0001867 GO:0002020 GO:0005509 GO:0005537 GO:0005581 GO:0005615 GO:0005771 GO:0006958 GO:0030247 GO:0042802 GO:0042803 GO:0043129 GO:0048306 GO:0050766 GO:0050830 GO:0051873 GO:0070207 GO:0070273 GO:0070492 GO:0120153
GL_001111	Sialic acid-binding Ig-like lectin 10		Sialic acid-binding Ig-like lectin 10	Q96LC7				Homo sapiens	9606	5400	SH2 domain binding adaptive immune response carbohydrate binding cell adhesion extracellular region innate immune response negative regulation of inflammatory response to wounding phosphatase binding plasma membrane sialic acid binding	GO:0002250 GO:0005576 GO:0005886 GO:0007155 GO:0019902 GO:0030246 GO:0033691 GO:0042169 GO:0045087 GO:0106015
GL_002073	Sialic acid-binding Ig-like lectin 12		Sialic acid-binding Ig-like lectin 12	Q91Y57				Mus musculus	10090	5403	cell adhesion external side of plasma membrane inflammatory response membrane monosaccharide binding negative regulation of inflammatory response negative regulation of phagocytosis, engulfment phagocytosis, engulfment plasma membrane sialic acid binding	GO:0005886 GO:0006911 GO:0006954 GO:0007155 GO:0009897 GO:0016020 GO:0033691 GO:0048029 GO:0050728 GO:0060101
GL_000380	F17e-G fimbrial adhesin		F17e-G fimbrial adhesin	Q9RH92	2BSB			Escherichia coli	562		adhesion of symbiont to host carbohydrate binding cell adhesion pilus	GO:0007155 GO:0009289 GO:0030246 GO:0044406
GL_001591	Glucans biosynthesis protein G		Glucans biosynthesis protein G	B7LT86				Escherichia fergusonii ATCC 35469	585054		carbohydrate binding catalytic activity glucan biosynthetic process periplasmic space	GO:0003824 GO:0009250 GO:0030246 GO:0042597
GL_001251	Alpha-xylosidase BoGH31A		Alpha-xylosidase BoGH31A	A7LXT0	5JOU 5JOV			Bacteroides ovatus ATCC 8483	411476		alpha-D-xyloside xylohydrolase carbohydrate binding hydrolase activity, hydrolyzing O-glycosyl compounds plasma membrane symbiotic process benefiting host xyloglucan catabolic process	GO:0004553 GO:0005886 GO:0030246 GO:0061634 GO:0085030 GO:2000899
GL_000513	Galectin-9		Galectin-9	P97840				Rattus norvegicus	10116		ERK1 and ERK2 cascade carbohydrate binding cellular response to type II interferon cellular response to virus cytoplasm cytosol disaccharide binding enzyme binding extracellular space female pregnancy galactoside binding inflammatory response maintenance of protein location maternal process involved in female pregnancy monoatomic ion transport natural killer cell tolerance induction negative regulation of CD4-positive, alpha-beta T cell proliferation negative regulation of activated T cell proliferation negative regulation of chemokine production negative regulation of gene expression negative regulation of inflammatory response negative regulation of mast cell degranulation negative regulation of natural killer cell activation negative regulation of natural killer cell degranulation negative regulation of natural killer cell mediated cytotoxicity negative regulation of tumor necrosis factor production negative regulation of type II interferon production nucleus p38MAPK cascade plasma membrane positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response positive regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of ERK1 and ERK2 cascade positive regulation of SMAD protein signal transduction positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell positive regulation of T cell migration positive regulation of activated T cell autonomous cell death positive regulation of chemokine production positive regulation of cytokine production positive regulation of defense response to bacterium positive regulation of dendritic cell apoptotic process positive regulation of dendritic cell chemotaxis positive regulation of dendritic cell differentiation positive regulation of gene expression positive regulation of innate immune response positive regulation of interleukin-1 beta production positive regulation of interleukin-1 production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of macrophage activation positive regulation of monocyte chemotactic protein-1 production positive regulation of non-canonical NF-kappaB signal transduction positive regulation of regulatory T cell differentiation positive regulation of transforming growth factor beta production positive regulation of tumor necrosis factor production positive regulation of type II interferon production positive regulation of viral entry into host cell protein serine/threonine kinase activator activity receptor clustering regulation of natural killer cell differentiation response to interleukin-1 response to lipopolysaccharide signaling receptor binding toll-like receptor 3 signaling pathway transforming growth factor beta receptor signaling pathway	GO:0001819 GO:0002519 GO:0005102 GO:0005615 GO:0005634 GO:0005737 GO:0005829 GO:0005886 GO:0006811 GO:0006954 GO:0007179 GO:0007565 GO:0010628 GO:0010629 GO:0016936 GO:0019899 GO:0030246 GO:0032496 GO:0032682 GO:0032689 GO:0032720 GO:0032722 GO:0032729 GO:0032731 GO:0032732 GO:0032733 GO:0032735 GO:0032736 GO:0032753 GO:0032755 GO:0032757 GO:0032760 GO:0032815 GO:0032823 GO:0032834 GO:0034138 GO:0038066 GO:0043032 GO:0043113 GO:0043305 GO:0043322 GO:0043539 GO:0045089 GO:0045185 GO:0045591 GO:0045953 GO:0046007 GO:0046598 GO:0048030 GO:0050728 GO:0060135 GO:0060391 GO:0070241 GO:0070371 GO:0070374 GO:0070555 GO:0071346 GO:0071636 GO:0071639 GO:0098586 GO:1900426 GO:1901224 GO:2000406 GO:2000510 GO:2000562 GO:2000563 GO:2000670 GO:2001190 GO:2001200
GL_000974	Protein FAM3C		Protein FAM3C	Q7ZYY4				Danio rerio	7955		carbohydrate binding extracellular space	GO:0005615 GO:0030246
GL_001404	Chondroitin sulfate ABC endolyase		Chondroitin sulfate ABC endolyase	P59807	1HN0 7EIP 7EIQ 7EIR 7EIS 7YKE			Proteus vulgaris	585		carbohydrate binding carbohydrate metabolic process chondroitin-sulfate-ABC endolyase activity extracellular region glycosaminoglycan catabolic process metal ion binding periplasmic space	GO:0005576 GO:0005975 GO:0006027 GO:0030246 GO:0034000 GO:0042597 GO:0046872