GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	Short Names ▲	Lectin Name All	UniProt ID	PDB IDs	LfDB IDs	Monosaccharide Specificities	Species	Taxonomy ID	MCAW IDs	GO Labels	GO IDs
GL_000487	Galectin-2	Galectin-2 (Human)	Galectin-2 (Human) Galectin-2	P05162	1HLC 5DG1 5DG2 5EWS	LfDB0055	Gal	Homo sapiens	9606	5110	T cell homeostasis carbohydrate binding cell-cell adhesion galactoside binding galectin complex positive regulation of apoptotic process positive regulation of inflammatory response	GO:0016936 GO:0030246 GO:0043029 GO:0043065 GO:0050729 GO:0098609 GO:1990724
GL_000489	Galectin-2	Galectin-2 (Rat)	Galectin-2 (Rat) Galectin-2	Q9Z144		LfDB0052		Rattus norvegicus	10116		T cell homeostasis carbohydrate binding cell-cell adhesion galactoside binding galectin complex positive regulation of apoptotic process positive regulation of inflammatory response	GO:0016936 GO:0030246 GO:0043029 GO:0043065 GO:0050729 GO:0098609 GO:1990724
GL_000501	Galectin-4	Galectin-4	Galectin-4 Galectin-4	P56470	1X50 4XZP 4YLZ 4YM0 4YM1 4YM2 4YM3 5CBL 5DUU 5DUV 5DUW 5DUX 6WAB	LfDB0272		Homo sapiens	9606	523	antibacterial peptide biosynthetic process carbohydrate binding cell adhesion collagen-containing extracellular matrix cytosol extracellular space galactoside binding plasma membrane	GO:0002780 GO:0005615 GO:0005829 GO:0005886 GO:0007155 GO:0016936 GO:0030246 GO:0062023
GL_000507	Galectin-7	Galectin-7 (Human)	Galectin-7 (Human) Galectin-7	P47929	1BKZ 2GAL 3GAL 3ZXE 3ZXF 4GAL 4UW3 4UW4 4UW5 4UW6 4XBQ 4Y26 5GAL 5H9Q 5H9S 6VTO 6VTP 6VTQ 6VTR 6VTS 7N4O 7N57 7N6C 7N8D 7N8G 7N96 7RDG 7TKW 7TKX 7TKY 7TKZ 7TRN 7TRO 7XAC 7XBL	LfDB0058	Gal	Homo sapiens	9606	1461 1702 1703 1710 5107	apoptotic process carbohydrate binding cytoplasm extracellular exosome extracellular space heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules nucleus	GO:0005615 GO:0005634 GO:0005737 GO:0006915 GO:0007157 GO:0030246 GO:0070062
GL_000509	Galectin-8	Galectin-8	Galectin-8 Galectin-8	O00214	2YRO 2YV8 2YXS 3AP4 3AP5 3AP6 3AP7 3AP9 3APB 3OJB 3VKL 3VKM 3VKN 3VKO 4BMB 4BME 4FQZ 4GXL 4HAN 5GZC 5GZD 5GZE 5GZF 5GZG 5T7I 5T7S 5T7T 5T7U 5VWG 6W4Z 6Z6Y 7AEN 7ALS 7P1M 8HL9	LfDB0273		Homo sapiens	9606	4565	carbohydrate binding cellular response to virus cytoplasm cytoplasmic vesicle cytosol extracellular space integrin binding lymphatic endothelial cell migration membrane xenophagy	GO:0005178 GO:0005615 GO:0005737 GO:0005829 GO:0016020 GO:0030246 GO:0031410 GO:0098586 GO:0098792 GO:1904977
GL_000514	Galectin-9	Galectin-9	Galectin-9 Galectin-9	O00182	2EAK 2EAL 2YY1 2ZHK 2ZHL 2ZHM 2ZHN 3LSD 3LSE 3NV1 3NV2 3NV3 3NV4 3WLU 3WV6	LfDB0274		Homo sapiens	9606	1935 2987	ERK1 and ERK2 cascade carbohydrate binding cellular response to type II interferon cellular response to virus chemotaxis collagen-containing extracellular matrix cytoplasm cytosol disaccharide binding enzyme binding extracellular space female pregnancy galactose binding galactoside binding inflammatory response maternal process involved in female pregnancy natural killer cell tolerance induction negative regulation of CD4-positive, alpha-beta T cell proliferation negative regulation of activated T cell proliferation negative regulation of chemokine production negative regulation of gene expression negative regulation of mast cell degranulation negative regulation of natural killer cell mediated cytotoxicity negative regulation of tumor necrosis factor production negative regulation of type II interferon production nucleus p38MAPK cascade positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response positive regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of ERK1 and ERK2 cascade positive regulation of NF-kappaB transcription factor activity positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell positive regulation of activated T cell autonomous cell death positive regulation of canonical NF-kappaB signal transduction positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway positive regulation of dendritic cell apoptotic process positive regulation of dendritic cell chemotaxis positive regulation of dendritic cell differentiation positive regulation of gene expression positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of monocyte chemotactic protein-1 production positive regulation of non-canonical NF-kappaB signal transduction positive regulation of transforming growth factor beta production positive regulation of tumor necrosis factor production positive regulation of type II interferon production positive regulation of viral entry into host cell response to interleukin-1 response to lipopolysaccharide	GO:0002519 GO:0005534 GO:0005615 GO:0005634 GO:0005737 GO:0005829 GO:0006935 GO:0006954 GO:0007565 GO:0010628 GO:0010629 GO:0016936 GO:0019899 GO:0030246 GO:0032496 GO:0032682 GO:0032689 GO:0032720 GO:0032729 GO:0032731 GO:0032733 GO:0032735 GO:0032736 GO:0032753 GO:0032755 GO:0032757 GO:0032760 GO:0032834 GO:0038066 GO:0043123 GO:0043305 GO:0045953 GO:0046007 GO:0046598 GO:0048030 GO:0051092 GO:0060135 GO:0062023 GO:0070241 GO:0070371 GO:0070374 GO:0070555 GO:0071346 GO:0071636 GO:0071639 GO:0098586 GO:1901224 GO:2000510 GO:2000562 GO:2000563 GO:2000670 GO:2001190 GO:2001200 GO:2001269
GL_002430		HHA HHL	HHA HHL			LfDB0207	Man
GL_001939	Agglutinin	HPA	HPA Agglutinin	Q2F1K8	2CCV 2CE6 2CGY 2CGZ	LfDB0105		Helix pomatia	6536	1356 1357 1358 1359 4881 4882	carbohydrate binding cell adhesion metal ion binding	GO:0007155 GO:0030246 GO:0046872
GL_001966	Lectin 1	Heltuba	Heltuba Lectin 1	Q9ZQY5	1C3K 1C3M 1C3N	LfDB0158	Glc Man	Helianthus tuberosus	4233		carbohydrate binding	GO:0030246
GL_000549	Hypnin-A3	HypninA3	HypninA3 Hypnin-A3	P85888		LfDB0258		Hypnea japonica	105606		carbohydrate binding	GO:0030246