GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	Short Names	Lectin Name All	UniProt ID	PDB IDs	LfDB IDs ▼	Monosaccharide Specificities	Species	Taxonomy ID	MCAW IDs	GO Labels	GO IDs
GL_001988	C-type lectin domain family 10 member A	mMGL1(WT)	mMGL1(WT) C-type lectin domain family 10 member A	P49300		LfDB0375		Mus musculus	10090	1637	connective tissue replacement involved in inflammatory response wound healing external side of plasma membrane fucose binding mannose binding	GO:0002248 GO:0005537 GO:0009897 GO:0042806
GL_001937	29-kDa galactose-binding lectin	EW29	EW29 29-kDa galactose-binding lectin	O96048	2DRY 2DRZ 2DS0 2RST 2ZQN 2ZQO	LfDB0357		Lumbricus terrestris	6398		carbohydrate binding	GO:0030246
GL_001952	Mannose-specific lectin KM+	Artocarpin	Artocarpin Mannose-specific lectin KM+	Q7M1T4	1J4S 1J4T 1J4U 1VBO 1VBP 4AKD	LfDB0294	Glc Man	Artocarpus integer	3490		carbohydrate binding	GO:0030246
GL_001380	C-type lectin domain family 4 member M	DCSIGNR CRD Fc	DCSIGNR CRD Fc C-type lectin domain family 4 member M	Q9H2X3	1K9J 1SL6 1XAR 1XPH 3JQH	LfDB0278		Homo sapiens	9606		ICAM-3 receptor activity adaptive immune response antigen processing and presentation calcium-dependent protein binding carbohydrate binding cell-cell recognition cytoplasm external side of plasma membrane extracellular region host cell immune response innate immune response intracellular signal transduction intracellular transport of virus leukocyte cell-cell adhesion mannose binding membrane metal ion binding peptide antigen binding peptide antigen transport plasma membrane receptor-mediated endocytosis of virus by host cell receptor-mediated virion attachment to host cell signaling receptor activity viral entry into host cell viral genome replication virion attachment to host cell virion binding virus receptor activity	GO:0001618 GO:0002250 GO:0005537 GO:0005576 GO:0005737 GO:0005886 GO:0006955 GO:0007159 GO:0009897 GO:0009988 GO:0016020 GO:0019062 GO:0019065 GO:0019079 GO:0019882 GO:0030246 GO:0030369 GO:0035556 GO:0038023 GO:0042605 GO:0043657 GO:0045087 GO:0046718 GO:0046790 GO:0046813 GO:0046872 GO:0046968 GO:0048306 GO:0075733
GL_000514	Galectin-9	Galectin-9	Galectin-9 Galectin-9	O00182	2EAK 2EAL 2YY1 2ZHK 2ZHL 2ZHM 2ZHN 3LSD 3LSE 3NV1 3NV2 3NV3 3NV4 3WLU 3WV6	LfDB0274		Homo sapiens	9606	1935 2987	ERK1 and ERK2 cascade carbohydrate binding cellular response to type II interferon cellular response to virus chemotaxis collagen-containing extracellular matrix cytoplasm cytosol disaccharide binding enzyme binding extracellular space female pregnancy galactose binding galactoside binding inflammatory response maternal process involved in female pregnancy natural killer cell tolerance induction negative regulation of CD4-positive, alpha-beta T cell proliferation negative regulation of activated T cell proliferation negative regulation of chemokine production negative regulation of gene expression negative regulation of mast cell degranulation negative regulation of natural killer cell mediated cytotoxicity negative regulation of tumor necrosis factor production negative regulation of type II interferon production nucleus p38MAPK cascade positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response positive regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of ERK1 and ERK2 cascade positive regulation of NF-kappaB transcription factor activity positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell positive regulation of activated T cell autonomous cell death positive regulation of canonical NF-kappaB signal transduction positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway positive regulation of dendritic cell apoptotic process positive regulation of dendritic cell chemotaxis positive regulation of dendritic cell differentiation positive regulation of gene expression positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of monocyte chemotactic protein-1 production positive regulation of non-canonical NF-kappaB signal transduction positive regulation of transforming growth factor beta production positive regulation of tumor necrosis factor production positive regulation of type II interferon production positive regulation of viral entry into host cell response to interleukin-1 response to lipopolysaccharide	GO:0002519 GO:0005534 GO:0005615 GO:0005634 GO:0005737 GO:0005829 GO:0006935 GO:0006954 GO:0007565 GO:0010628 GO:0010629 GO:0016936 GO:0019899 GO:0030246 GO:0032496 GO:0032682 GO:0032689 GO:0032720 GO:0032729 GO:0032731 GO:0032733 GO:0032735 GO:0032736 GO:0032753 GO:0032755 GO:0032757 GO:0032760 GO:0032834 GO:0038066 GO:0043123 GO:0043305 GO:0045953 GO:0046007 GO:0046598 GO:0048030 GO:0051092 GO:0060135 GO:0062023 GO:0070241 GO:0070371 GO:0070374 GO:0070555 GO:0071346 GO:0071636 GO:0071639 GO:0098586 GO:1901224 GO:2000510 GO:2000562 GO:2000563 GO:2000670 GO:2001190 GO:2001200 GO:2001269
GL_000509	Galectin-8	Galectin-8	Galectin-8 Galectin-8	O00214	2YRO 2YV8 2YXS 3AP4 3AP5 3AP6 3AP7 3AP9 3APB 3OJB 3VKL 3VKM 3VKN 3VKO 4BMB 4BME 4FQZ 4GXL 4HAN 5GZC 5GZD 5GZE 5GZF 5GZG 5T7I 5T7S 5T7T 5T7U 5VWG 6W4Z 6Z6Y 7AEN 7ALS 7P1M 8HL9	LfDB0273		Homo sapiens	9606	4565	carbohydrate binding cellular response to virus cytoplasm cytoplasmic vesicle cytosol extracellular space integrin binding lymphatic endothelial cell migration membrane xenophagy	GO:0005178 GO:0005615 GO:0005737 GO:0005829 GO:0016020 GO:0030246 GO:0031410 GO:0098586 GO:0098792 GO:1904977
GL_000501	Galectin-4	Galectin-4	Galectin-4 Galectin-4	P56470	1X50 4XZP 4YLZ 4YM0 4YM1 4YM2 4YM3 5CBL 5DUU 5DUV 5DUW 5DUX 6WAB	LfDB0272		Homo sapiens	9606	523	antibacterial peptide biosynthetic process carbohydrate binding cell adhesion collagen-containing extracellular matrix cytosol extracellular space galactoside binding plasma membrane	GO:0002780 GO:0005615 GO:0005829 GO:0005886 GO:0007155 GO:0016936 GO:0030246 GO:0062023
GL_000469	Galectin-1	Galectin-1	Galectin-1 Galectin-1	P09382	1GZW 1W6M 1W6N 1W6O 1W6P 1W6Q 2KM2 2ZKN 3OY8 3OYW 3T2T 3W58 3W59 4Q1P 4Q1R 4Q26 4Q27 4Q2F 4XBL 4Y1U 4Y1V 4Y1X 4Y1Y 4Y1Z 4Y20 4Y22 4Y24 5MWT 5MWX 6B94 6F83 6M5Y 7LTA 7NML 8B0W 8B0Z	LfDB0270		Homo sapiens	9606	1273 1290 1291 1292 1720 1723 1724 1725 295 296 2985 2989 2991 2992 2993 2996 416 417 5109	RNA binding T cell costimulation apoptotic process carbohydrate binding cell-cell adhesion collagen-containing extracellular matrix cytoplasm cytosol endoplasmic reticulum lumen extracellular exosome extracellular region extracellular space galectin complex laminin binding myoblast differentiation plasma cell differentiation positive regulation of apoptotic process positive regulation of canonical NF-kappaB signal transduction positive regulation of inflammatory response positive regulation of viral entry into host cell regulation of apoptotic process	GO:0002317 GO:0003723 GO:0005576 GO:0005615 GO:0005737 GO:0005788 GO:0005829 GO:0006915 GO:0030246 GO:0031295 GO:0042981 GO:0043065 GO:0043123 GO:0043236 GO:0045445 GO:0046598 GO:0050729 GO:0062023 GO:0070062 GO:0098609 GO:1990724
GL_000549	Hypnin-A3	HypninA3	HypninA3 Hypnin-A3	P85888		LfDB0258		Hypnea japonica	105606		carbohydrate binding	GO:0030246
GL_000723	Lectin BRA-3	BRA3	BRA3 Lectin BRA-3	P07439		LfDB0248	Gal Man	Megabalanus rosa	6680		carbohydrate binding	GO:0030246