GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	Short Names	Lectin Name All	UniProt ID	PDB IDs	LfDB IDs	Monosaccharide Specificities	Species	Taxonomy ID	MCAW IDs ▲	GO Labels	GO IDs
GL_000491	Galectin-3	Gal3 Galectin-3 (Human)	Gal3 Galectin-3 (Human) Galectin-3	P17931	1A3K 1KJL 1KJR 2NMN 2NMO 2NN8 2XG3 3AYA 3AYC 3AYD 3AYE 3T1L 3T1M 3ZSJ 3ZSK 3ZSL 3ZSM 4BLI 4BLJ 4BM8 4JC1 4JCK 4LBJ 4LBK 4LBL 4LBM 4LBN 4LBO 4R9A 4R9B 4R9C 4R9D 4RL7 4XBN 5E88 5E89 5E8A 5EXO 5H9P 5H9R 5IUQ 5NF7 5NF9 5NFA 5NFB 5NFC 5OAX 5ODY 6B8K 6EOG 6EOL 6EXY 6EYM 6F2Q 6F6Y 6FK2 6FOF 6G0V 6H64 6I74 6I75 6I76 6I77 6I78 6KXA 6KXB 6Q0Q 6Q17 6QGE 6QGF 6QLN 6QLO 6QLP 6QLQ 6QLR 6QLS 6QLT 6QLU 6RHL 6RHM 6RZF 6RZG 6RZH 6RZI 6RZJ 6RZK 6RZL 6RZM 6TF6 6TF7 6Y4C 6Y78 6ZVF 7BE3 7CXA 7DF5 7RDO 7RDP 7RGX 7RGY 7RGZ 7RH0 7RH1 7RH3 7RH4 7XFA 7ZQX 8BZ3 8OJI 8OJK 8OJM 8OJO 8PPN	LfDB0056 LfDB0065	Gal	Homo sapiens	9606	103 104 106 107 108 115 116 5108	IgE binding RNA binding RNA splicing carbohydrate binding cell surface chemoattractant activity collagen-containing extracellular matrix cytoplasm cytosol eosinophil chemotaxis epithelial cell differentiation extracellular exosome extracellular region extracellular space ficolin-1-rich granule membrane immunological synapse innate immune response laminin binding mRNA processing macrophage chemotaxis membrane mitochondrial inner membrane molecular condensate scaffold activity monocyte chemotaxis mononuclear cell migration negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell negative regulation of T cell receptor signaling pathway negative regulation of endocytosis negative regulation of extrinsic apoptotic signaling pathway negative regulation of immunological synapse formation negative regulation of protein tyrosine phosphatase activity neutrophil chemotaxis nucleoplasm nucleus plasma membrane positive chemotaxis positive regulation of calcium ion import positive regulation of mononuclear cell migration positive regulation of protein localization to plasma membrane positive regulation of protein-containing complex assembly protein phosphatase binding protein phosphatase inhibitor activity regulation of T cell apoptotic process regulation of T cell proliferation regulation of extrinsic apoptotic signaling pathway via death domain receptors secretory granule membrane spliceosomal complex	GO:0001772 GO:0002548 GO:0003723 GO:0004864 GO:0005576 GO:0005615 GO:0005634 GO:0005654 GO:0005681 GO:0005737 GO:0005743 GO:0005829 GO:0005886 GO:0006397 GO:0008380 GO:0009986 GO:0016020 GO:0019863 GO:0019903 GO:0030246 GO:0030593 GO:0030667 GO:0030855 GO:0031334 GO:0042056 GO:0042129 GO:0043236 GO:0045087 GO:0045806 GO:0048245 GO:0048246 GO:0050860 GO:0050918 GO:0062023 GO:0070062 GO:0070232 GO:0071674 GO:0071677 GO:0090280 GO:0101003 GO:0140693 GO:1902041 GO:1903078 GO:1903614 GO:2000521 GO:2001189 GO:2001237
GL_001953	Hemolytic lectin LSLa		Hemolytic lectin LSLa	Q7Z8V1	1W3A 1W3F 1W3G 2Y9F 2Y9G			Laetiporus sulphureus	5630	1268 1269 1289	carbohydrate binding	GO:0030246
GL_002120	Predicted protein		Predicted protein	B0D650	8B8F 8B97			Laccaria bicolor S238N-H82	486041	1270 1271
GL_000469	Galectin-1	Galectin-1	Galectin-1 Galectin-1	P09382	1GZW 1W6M 1W6N 1W6O 1W6P 1W6Q 2KM2 2ZKN 3OY8 3OYW 3T2T 3W58 3W59 4Q1P 4Q1R 4Q26 4Q27 4Q2F 4XBL 4Y1U 4Y1V 4Y1X 4Y1Y 4Y1Z 4Y20 4Y22 4Y24 5MWT 5MWX 6B94 6F83 6M5Y 7LTA 7NML 8B0W 8B0Z	LfDB0270		Homo sapiens	9606	1273 1290 1291 1292 1720 1723 1724 1725 295 296 2985 2989 2991 2992 2993 2996 416 417 5109	RNA binding T cell costimulation apoptotic process carbohydrate binding cell-cell adhesion collagen-containing extracellular matrix cytoplasm cytosol endoplasmic reticulum lumen extracellular exosome extracellular region extracellular space galectin complex laminin binding myoblast differentiation plasma cell differentiation positive regulation of apoptotic process positive regulation of canonical NF-kappaB signal transduction positive regulation of inflammatory response positive regulation of viral entry into host cell regulation of apoptotic process	GO:0002317 GO:0003723 GO:0005576 GO:0005615 GO:0005737 GO:0005788 GO:0005829 GO:0006915 GO:0030246 GO:0031295 GO:0042981 GO:0043065 GO:0043123 GO:0043236 GO:0045445 GO:0046598 GO:0050729 GO:0062023 GO:0070062 GO:0098609 GO:1990724
GL_001939	Agglutinin	HPA	HPA Agglutinin	Q2F1K8	2CCV 2CE6 2CGY 2CGZ	LfDB0105		Helix pomatia	6536	1356 1357 1358 1359 4881 4882	carbohydrate binding cell adhesion metal ion binding	GO:0007155 GO:0030246 GO:0046872
GL_001022	Pulmonary surfactant-associated protein D		Pulmonary surfactant-associated protein D	P35247	1B08 1M7L 1PW9 1PWB 2GGU 2GGX 2ORJ 2ORK 2OS9 2RIA 2RIB 2RIC 2RID 2RIE 3DBZ 3G81 3G83 3G84 3IKN 3IKP 3IKQ 3IKR 4E52 4M17 4M18 5OXR 5OXS			Homo sapiens	9606	1417 1452 1477	carbohydrate binding clathrin-coated endocytic vesicle collagen trimer defense response to bacterium endocytic vesicle endoplasmic reticulum membrane extracellular region extracellular space identical protein binding innate immune response lung alveolus development lysosome macrophage chemotaxis multivesicular body negative regulation of T cell proliferation negative regulation of interleukin-2 production positive regulation of phagocytosis reactive oxygen species metabolic process receptor-mediated endocytosis regulation of cytokine production respiratory gaseous exchange by respiratory system surfactant homeostasis	GO:0001817 GO:0005576 GO:0005581 GO:0005615 GO:0005764 GO:0005771 GO:0005789 GO:0006898 GO:0007585 GO:0030139 GO:0030246 GO:0032703 GO:0042130 GO:0042742 GO:0042802 GO:0043129 GO:0045087 GO:0045334 GO:0048246 GO:0048286 GO:0050766 GO:0072593
GL_000507	Galectin-7	Galectin-7 (Human)	Galectin-7 (Human) Galectin-7	P47929	1BKZ 2GAL 3GAL 3ZXE 3ZXF 4GAL 4UW3 4UW4 4UW5 4UW6 4XBQ 4Y26 5GAL 5H9Q 5H9S 6VTO 6VTP 6VTQ 6VTR 6VTS 7N4O 7N57 7N6C 7N8D 7N8G 7N96 7RDG 7TKW 7TKX 7TKY 7TKZ 7TRN 7TRO 7XAC 7XBL	LfDB0058	Gal	Homo sapiens	9606	1461 1702 1703 1710 5107	apoptotic process carbohydrate binding cytoplasm extracellular exosome extracellular space heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules nucleus	GO:0005615 GO:0005634 GO:0005737 GO:0006915 GO:0007157 GO:0030246 GO:0070062
GL_001980	Anti-tumor lectin (Fragment)		Anti-tumor lectin (Fragment)	Q6WY08	1WW4 1WW5 1WW6 1WW7 2ZGK 2ZGL 2ZGM 2ZGN 2ZGO 2ZGP 2ZGQ 2ZGR 2ZGS 2ZGT 2ZGU 3AFK 3M3C 3M3E 3M3O 3M3Q 3WG1 3WG2 3WG3 3WG4			Cyclocybe aegerita	1973307	1472	DNA nuclease activity apoptotic process polysaccharide binding positive regulation of apoptotic process	GO:0004536 GO:0006915 GO:0030247 GO:0043065
GL_002400	Capsid protein VP1		Capsid protein VP1	Q83884	1IHM 2ZL5 2ZL6 2ZL7 3BY1 3BY2 3D26 5KW9 5N7M 6CRJ 6H6Y 6H6Z 6H70 6H71 6H72 6OUT 7KJP			Norovirus Hu/1968/US	524364	1542	T=3 icosahedral viral capsid host cell cytoplasm identical protein binding	GO:0030430 GO:0039617 GO:0042802
GL_001988	C-type lectin domain family 10 member A	mMGL1(WT)	mMGL1(WT) C-type lectin domain family 10 member A	P49300		LfDB0375		Mus musculus	10090	1637	connective tissue replacement involved in inflammatory response wound healing external side of plasma membrane fucose binding mannose binding	GO:0002248 GO:0005537 GO:0009897 GO:0042806