GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	Short Names	Lectin Name All	UniProt ID	PDB IDs ▲	LfDB IDs	Monosaccharide Specificities	Species	Taxonomy ID	MCAW IDs	GO Labels	GO IDs
GL_001450	Endoglucanase 5A		Endoglucanase 5A	O85465	1A3H 1E5J 1H11 1H2J 1H5V 1HF6 1OCQ 1QHZ 1QI0 1QI2 1W3K 1W3L 2A3H 2V38 3A3H 4A3H 5A3H 6A3H 7A3H 8A3H			Salipaludibacillus agaradhaerens	76935		carbohydrate binding cellulase activity cellulose catabolic process extracellular region	GO:0005576 GO:0008810 GO:0030245 GO:0030246
GL_000491	Galectin-3	Gal3 Galectin-3 (Human)	Gal3 Galectin-3 (Human) Galectin-3	P17931	1A3K 1KJL 1KJR 2NMN 2NMO 2NN8 2XG3 3AYA 3AYC 3AYD 3AYE 3T1L 3T1M 3ZSJ 3ZSK 3ZSL 3ZSM 4BLI 4BLJ 4BM8 4JC1 4JCK 4LBJ 4LBK 4LBL 4LBM 4LBN 4LBO 4R9A 4R9B 4R9C 4R9D 4RL7 4XBN 5E88 5E89 5E8A 5EXO 5H9P 5H9R 5IUQ 5NF7 5NF9 5NFA 5NFB 5NFC 5OAX 5ODY 6B8K 6EOG 6EOL 6EXY 6EYM 6F2Q 6F6Y 6FK2 6FOF 6G0V 6H64 6I74 6I75 6I76 6I77 6I78 6KXA 6KXB 6Q0Q 6Q17 6QGE 6QGF 6QLN 6QLO 6QLP 6QLQ 6QLR 6QLS 6QLT 6QLU 6RHL 6RHM 6RZF 6RZG 6RZH 6RZI 6RZJ 6RZK 6RZL 6RZM 6TF6 6TF7 6Y4C 6Y78 6ZVF 7BE3 7CXA 7DF5 7RDO 7RDP 7RGX 7RGY 7RGZ 7RH0 7RH1 7RH3 7RH4 7XFA 7ZQX 8BZ3 8OJI 8OJK 8OJM 8OJO 8PPN	LfDB0056 LfDB0065	Gal	Homo sapiens	9606	103 104 106 107 108 115 116 5108	IgE binding RNA binding RNA splicing carbohydrate binding cell surface chemoattractant activity collagen-containing extracellular matrix cytoplasm cytosol eosinophil chemotaxis epithelial cell differentiation extracellular exosome extracellular region extracellular space ficolin-1-rich granule membrane immunological synapse innate immune response laminin binding mRNA processing macrophage chemotaxis membrane mitochondrial inner membrane molecular condensate scaffold activity monocyte chemotaxis mononuclear cell migration negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell negative regulation of T cell receptor signaling pathway negative regulation of endocytosis negative regulation of extrinsic apoptotic signaling pathway negative regulation of immunological synapse formation negative regulation of protein tyrosine phosphatase activity neutrophil chemotaxis nucleoplasm nucleus plasma membrane positive chemotaxis positive regulation of calcium ion import positive regulation of mononuclear cell migration positive regulation of protein localization to plasma membrane positive regulation of protein-containing complex assembly protein phosphatase binding protein phosphatase inhibitor activity regulation of T cell apoptotic process regulation of T cell proliferation regulation of extrinsic apoptotic signaling pathway via death domain receptors secretory granule membrane spliceosomal complex	GO:0001772 GO:0002548 GO:0003723 GO:0004864 GO:0005576 GO:0005615 GO:0005634 GO:0005654 GO:0005681 GO:0005737 GO:0005743 GO:0005829 GO:0005886 GO:0006397 GO:0008380 GO:0009986 GO:0016020 GO:0019863 GO:0019903 GO:0030246 GO:0030593 GO:0030667 GO:0030855 GO:0031334 GO:0042056 GO:0042129 GO:0043236 GO:0045087 GO:0045806 GO:0048245 GO:0048246 GO:0050860 GO:0050918 GO:0062023 GO:0070062 GO:0070232 GO:0071674 GO:0071677 GO:0090280 GO:0101003 GO:0140693 GO:1902041 GO:1903078 GO:1903614 GO:2000521 GO:2001189 GO:2001237
GL_000476	Galectin-1		Galectin-1	P56217	1A78 1GAN			Rhinella arenarum	38577		carbohydrate binding extracellular region	GO:0005576 GO:0030246
GL_002319	Tetanus toxin		Tetanus toxin	P04958	1A8D 1AF9 1D0H 1DFQ 1DIW 1DLL 1FV2 1FV3 1YVG 1YXW 1YYN 1Z7H 3HMY 3HN1 4J1L 5N0B 5N0C 7BXX 7BY4 7BY5 7OH0 7OH1			Clostridium tetani E88	212717	5164	clathrin-coated endocytic vesicle membrane cytosol endocytic vesicle membrane extracellular region metalloendopeptidase activity modulation by symbiont of host neurotransmitter secretion plasma membrane protein transmembrane transporter activity proteolysis toxin activity zinc ion binding	GO:0004222 GO:0005576 GO:0005829 GO:0005886 GO:0006508 GO:0008270 GO:0008320 GO:0030666 GO:0030669 GO:0044079 GO:0090729
GL_001675	L-arabinose-binding periplasmic protein		L-arabinose-binding periplasmic protein	P02924	1ABE 1ABF 1APB 1BAP 2WRZ 5ABP 6ABP 7ABP 8ABP 9ABP			Escherichia coli K-12	83333		ABC-type monosaccharide transporter activity ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing L-arabinose transmembrane transport carbohydrate binding membrane monosaccharide binding outer membrane-bounded periplasmic space	GO:0015407 GO:0016020 GO:0030246 GO:0030288 GO:0042882 GO:0048029 GO:0055052
GL_001976	Abrin-a		Abrin-a	P11140	1ABR 5Z37 5Z3I 5Z3J			Abrus precatorius	3816		defense response galactose binding negative regulation of translation positive regulation of endocytosis rRNA N-glycosylase activity toxin activity	GO:0005534 GO:0006952 GO:0017148 GO:0030598 GO:0045807 GO:0090729
GL_002261	Igh protein		Igh protein	Q99LC4	1AE6 1AFV 1E6J 1F58 1GIG 1JHK 1JNL 1JNN 2A1W 2NTF 2VIR 2VIS 2VIT 3HKF 4Q0X 5MP3 6C5H 6C5I 6C5J 6C5K			Mus musculus	10090		metal ion binding	GO:0046872
GL_002355	Mannose-binding protein A		Mannose-binding protein A	P19999	1AFA 1AFB 1AFD 1BCH 1BCJ 1BUU 1FIF 1FIH 1KMB 1KWT 1KWU 1KWV 1KWW 1KWX 1KWY 1KWZ 1KX0 1KX1 1MSB 1RTM 1YTT 2KMB 2MSB 3KMB 4KMB			Rattus norvegicus	10116	5397	calcium ion binding calcium-dependent carbohydrate binding calcium-dependent protein binding collagen trimer complement activation, classical pathway complement activation, lectin pathway defense response to Gram-positive bacterium extracellular space identical protein binding killing by host of symbiont cells mannose binding multivesicular body oligosaccharide binding phosphatidylinositol-4-phosphate binding polysaccharide binding positive regulation of phagocytosis protease binding protein homodimerization activity protein homotrimerization surfactant homeostasis	GO:0001867 GO:0002020 GO:0005509 GO:0005537 GO:0005581 GO:0005615 GO:0005771 GO:0006958 GO:0030247 GO:0042802 GO:0042803 GO:0043129 GO:0048306 GO:0050766 GO:0050830 GO:0051873 GO:0070207 GO:0070273 GO:0070492 GO:0120153
GL_001455	Endoglucanase Z		Endoglucanase Z	P07103	1AIW 1EGZ			Dickeya dadantii 3937	198628		carbohydrate binding cellulase activity cellulose catabolic process extracellular region	GO:0005576 GO:0008810 GO:0030245 GO:0030246
GL_001256	Annexin A4		Annexin A4	P13214	1ANN 1AOW 1I4A			Bos taurus	9913		NF-kappaB binding Notch signaling pathway apical plasma membrane calcium ion binding calcium-dependent phospholipid binding calcium-dependent protein binding carbohydrate binding cell surface chondroitin sulfate binding chromaffin granule membrane cytoplasm cytosol epithelial cell differentiation heparin binding identical protein binding membrane negative regulation of interleukin-8 production nuclear membrane nucleus perinuclear region of cytoplasm regulation of transcription by RNA polymerase II zymogen granule membrane	GO:0005509 GO:0005544 GO:0005634 GO:0005737 GO:0005829 GO:0006357 GO:0007219 GO:0008201 GO:0009986 GO:0016020 GO:0016324 GO:0030246 GO:0030855 GO:0031965 GO:0032717 GO:0035374 GO:0042584 GO:0042589 GO:0042802 GO:0048306 GO:0048471 GO:0051059