GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin ▼	Lectin Name	UniProt ID	Species	Taxonomy ID	GO Labels	GO IDs
GL_002343	Cation-independent mannose-6-phosphate receptor	P11717	Homo sapiens	9606	G protein-coupled receptor signaling pathway G-protein alpha-subunit binding Golgi apparatus Golgi membrane animal organ regeneration cell surface clathrin coat clathrin-coated endocytic vesicle membrane early endosome endocytic vesicle endosome endosome membrane enzyme binding extracellular exosome focal adhesion identical protein binding insulin-like growth factor II binding insulin-like growth factor binding insulin-like growth factor receptor activity late endosome liver development lysosomal transport mannose binding membrane nuclear envelope lumen perinuclear region of cytoplasm phosphoprotein binding plasma membrane positive regulation by host of viral process positive regulation of apoptotic process post-embryonic development receptor-mediated endocytosis response to retinoic acid response to tetrachloromethane retinoic acid binding retromer complex binding secretory granule membrane signal transduction signaling receptor activity spermatogenesis trans-Golgi network trans-Golgi network membrane trans-Golgi network transport vesicle transport vesicle	GO:0000139 GO:0001889 GO:0001965 GO:0001972 GO:0005010 GO:0005520 GO:0005537 GO:0005641 GO:0005768 GO:0005769 GO:0005770 GO:0005794 GO:0005802 GO:0005886 GO:0005925 GO:0006898 GO:0007041 GO:0007165 GO:0007186 GO:0007283 GO:0009791 GO:0009986 GO:0010008 GO:0016020 GO:0019899 GO:0030118 GO:0030133 GO:0030139 GO:0030140 GO:0030667 GO:0030669 GO:0031100 GO:0031995 GO:0032526 GO:0032588 GO:0038023 GO:0042802 GO:0043065 GO:0044794 GO:0048471 GO:0051219 GO:0070062 GO:1904772 GO:1905394
GL_002342	Cation-dependent mannose-6-phosphate receptor	P11456	Bos taurus	9913	Golgi apparatus endosome lysosomal membrane lysosomal transport protein domain specific binding protein targeting to lysosome trans-Golgi network	GO:0005765 GO:0005768 GO:0005794 GO:0005802 GO:0006622 GO:0007041 GO:0019904
GL_002341	Mannose-binding protein C	P11226	Homo sapiens	9606	acute-phase response antiviral innate immune response calcium-dependent protein binding cell surface cell surface pattern recognition receptor signaling pathway collagen trimer complement activation, classical pathway complement activation, lectin pathway defense response to Gram-positive bacterium defense response to bacterium external side of plasma membrane extracellular region extracellular space identical protein binding innate immune response killing by host of symbiont cells mannose binding multivesicular body negative regulation of viral process opsonization positive regulation of opsonization positive regulation of phagocytosis proteolysis response to oxidative stress serine-type endopeptidase complex signaling receptor binding surfactant homeostasis	GO:0001867 GO:0002752 GO:0005102 GO:0005537 GO:0005576 GO:0005581 GO:0005615 GO:0005771 GO:0006508 GO:0006953 GO:0006958 GO:0006979 GO:0008228 GO:0009897 GO:0009986 GO:0042742 GO:0042802 GO:0043129 GO:0045087 GO:0048306 GO:0048525 GO:0050766 GO:0050830 GO:0051873 GO:0140374 GO:1903028 GO:1905370
GL_002340	Outer capsid protein VP4	P11196	Human rotavirus (SEROTYPE 2 / STRAIN DS1)	10950	host cell endoplasmic reticulum-Golgi intermediate compartment host cell plasma membrane host cell rough endoplasmic reticulum host cytoskeleton membrane permeabilization of host organelle membrane involved in viral entry into host cell viral entry via permeabilization of inner membrane viral outer capsid virion attachment to host cell	GO:0016020 GO:0019062 GO:0020002 GO:0039624 GO:0039665 GO:0044163 GO:0044168 GO:0044172 GO:0099008
GL_002339	Outer capsid protein VP4	P11193	Human rotavirus strain WA	10962	host cell endoplasmic reticulum-Golgi intermediate compartment host cell plasma membrane host cell rough endoplasmic reticulum host cytoskeleton membrane permeabilization of host organelle membrane involved in viral entry into host cell viral entry via permeabilization of inner membrane viral outer capsid virion attachment to host cell	GO:0016020 GO:0019062 GO:0020002 GO:0039624 GO:0039665 GO:0044163 GO:0044168 GO:0044172 GO:0099008
GL_002338	Botulinum neurotoxin type B	P10844	Clostridium botulinum	1491	extracellular region host cell cytoplasmic vesicle host cell cytosol host cell plasma membrane host cell presynaptic membrane lipid binding membrane metalloendopeptidase activity protein transmembrane transporter activity proteolysis toxin activity zinc ion binding	GO:0004222 GO:0005576 GO:0006508 GO:0008270 GO:0008289 GO:0008320 GO:0016020 GO:0020002 GO:0044161 GO:0044164 GO:0044231 GO:0090729
GL_002337	Spike glycoprotein	P0DTC2	Severe acute respiratory syndrome coronavirus 2	2697049	entry receptor-mediated virion attachment to host cell fusion of virus membrane with host endosome membrane fusion of virus membrane with host plasma membrane host cell endoplasmic reticulum-Golgi intermediate compartment membrane host cell plasma membrane host cell surface host cell surface receptor binding host extracellular space identical protein binding membrane fusion plasma membrane positive regulation of viral entry into host cell receptor ligand activity receptor-mediated endocytosis of virus by host cell receptor-mediated virion attachment to host cell structural constituent of virion suppression by virus of host tetherin activity suppression by virus of host type I interferon-mediated signaling pathway viral envelope viral translation virion attachment to host cell virion membrane	GO:0005886 GO:0019031 GO:0019062 GO:0019064 GO:0019065 GO:0019081 GO:0020002 GO:0039502 GO:0039587 GO:0039654 GO:0039660 GO:0042802 GO:0043655 GO:0044173 GO:0044228 GO:0046598 GO:0046789 GO:0046813 GO:0048018 GO:0055036 GO:0061025 GO:0098670
GL_002336	Botulinum neurotoxin type A	P0DPI1	Clostridium botulinum A str. Hall	441771	extracellular region host cell cytoplasmic vesicle host cell cytosol host cell plasma membrane host cell presynaptic membrane membrane metalloendopeptidase activity protein transmembrane transporter activity proteolysis toxin activity zinc ion binding	GO:0004222 GO:0005576 GO:0006508 GO:0008270 GO:0008320 GO:0016020 GO:0020002 GO:0044161 GO:0044164 GO:0044231 GO:0090729
GL_002335	Botulinum neurotoxin type A	P0DPI0	Clostridium botulinum	1491	extracellular region ganglioside GT1b binding host cell cytoplasmic vesicle host cell cytosol host cell plasma membrane host cell presynaptic membrane membrane metalloendopeptidase activity protein transmembrane transporter activity proteolysis toxin activity zinc ion binding	GO:0004222 GO:0005576 GO:0006508 GO:0008270 GO:0008320 GO:0016020 GO:0020002 GO:0044161 GO:0044164 GO:0044231 GO:0090729 GO:1905576
GL_002334	Major capsid protein VP1	P0DOI3	KI polyomavirus Stockholm 60	423446	T=7 icosahedral viral capsid endocytosis involved in viral entry into host cell host cell nucleus structural molecule activity virion attachment to host cell	GO:0005198 GO:0019062 GO:0039620 GO:0042025 GO:0075509