GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	UniProt ID	Species	Taxonomy ID ▼	GO Labels	GO IDs
GL_000050	Aggrecan core protein	Q28343	Canis lupus familiaris	9615	calcium ion binding carbohydrate binding cell adhesion central nervous system development extracellular space glial cell differentiation hyaluronic acid binding perineuronal net positive regulation of neuroblast proliferation skeletal system development synapse	GO:0001501 GO:0002052 GO:0005509 GO:0005540 GO:0005615 GO:0007155 GO:0007417 GO:0010001 GO:0030246 GO:0045202 GO:0072534
GL_001365	Beta-glucuronidase	O18835	Canis lupus familiaris	9615	beta-glucuronidase activity carbohydrate binding carbohydrate metabolic process extracellular space glucuronoside catabolic process lysosome signaling receptor binding	GO:0004566 GO:0005102 GO:0005615 GO:0005764 GO:0005975 GO:0019391 GO:0030246
GL_001897	Zona pellucida sperm-binding protein 3	P48831	Canis lupus familiaris	9615	acrosin binding binding of sperm to zona pellucida blastocyst formation carbohydrate binding collagen-containing extracellular matrix egg coat egg coat formation extracellular matrix extracellular space humoral immune response mediated by circulating immunoglobulin negative regulation of DNA-templated transcription oocyte development plasma membrane positive regulation of DNA-templated transcription positive regulation of T cell proliferation positive regulation of acrosomal vesicle exocytosis positive regulation of acrosome reaction positive regulation of antral ovarian follicle growth positive regulation of humoral immune response positive regulation of inflammatory response positive regulation of interleukin-4 production positive regulation of leukocyte migration positive regulation of ovarian follicle development positive regulation of type II interferon production positive regulation of type IV hypersensitivity receptor ligand activity structural constituent of egg coat	GO:0001809 GO:0001825 GO:0002455 GO:0002687 GO:0002922 GO:0005615 GO:0005886 GO:0007339 GO:0030246 GO:0031012 GO:0032190 GO:0032729 GO:0032753 GO:0035803 GO:0035804 GO:0035805 GO:0042102 GO:0045892 GO:0045893 GO:0048018 GO:0048599 GO:0050729 GO:0062023 GO:2000344 GO:2000368 GO:2000386 GO:2000388
GL_002004	E-selectin	P33730	Canis lupus familiaris	9615	calcium ion binding external side of plasma membrane extracellular space heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules leukocyte tethering or rolling oligosaccharide binding positive regulation of leukocyte tethering or rolling response to cytokine sialic acid binding	GO:0005509 GO:0005615 GO:0007157 GO:0009897 GO:0033691 GO:0034097 GO:0050901 GO:0070492 GO:1903238
GL_001014	Pulmonary surfactant-associated protein A	P06908	Canis lupus familiaris	9615	carbohydrate binding collagen trimer extracellular space metal ion binding multivesicular body respiratory gaseous exchange by respiratory system	GO:0005581 GO:0005615 GO:0005771 GO:0007585 GO:0030246 GO:0046872
GL_000805	Natural killer cells antigen CD94	Q38HS3	Canis lupus familiaris	9615	adaptive immune response carbohydrate binding external side of plasma membrane innate immune response negative regulation of T cell mediated cytotoxicity negative regulation of natural killer cell mediated cytotoxicity plasma membrane positive regulation of natural killer cell mediated cytotoxicity stimulatory C-type lectin receptor signaling pathway transmembrane signaling receptor activity	GO:0001915 GO:0002223 GO:0002250 GO:0004888 GO:0005886 GO:0009897 GO:0030246 GO:0045087 GO:0045953 GO:0045954
GL_000496	Galectin-3	P38486	Canis lupus familiaris	9615	IgE binding RNA splicing carbohydrate binding cell differentiation cytoplasm eosinophil chemotaxis extracellular space immunological synapse innate immune response laminin binding mRNA processing macrophage chemotaxis monocyte chemotaxis negative regulation of endocytosis negative regulation of extrinsic apoptotic signaling pathway neutrophil chemotaxis nucleus positive chemotaxis positive regulation of calcium ion import spliceosomal complex	GO:0001772 GO:0002548 GO:0005615 GO:0005634 GO:0005681 GO:0005737 GO:0006397 GO:0008380 GO:0019863 GO:0030154 GO:0030246 GO:0030593 GO:0043236 GO:0045087 GO:0045806 GO:0048245 GO:0048246 GO:0050918 GO:0090280 GO:2001237
GL_001649	Hematopoietic progenitor cell antigen CD34	Q28270	Canis lupus familiaris	9615	apical plasma membrane basal plasma membrane carbohydrate binding cell-cell adhesion cell-matrix adhesion cytoplasm external side of plasma membrane glomerular endothelium fenestra glomerular filtration intercellular bridge leukocyte migration lysosome mesangial cell-matrix adhesion perinuclear region of cytoplasm plasma membrane positive regulation of angiogenesis positive regulation of odontogenesis positive regulation of vasculogenesis tissue homeostasis	GO:0001894 GO:0003094 GO:0005737 GO:0005764 GO:0005886 GO:0007160 GO:0009897 GO:0009925 GO:0016324 GO:0030246 GO:0035759 GO:0036053 GO:0042482 GO:0045171 GO:0045766 GO:0048471 GO:0050900 GO:0098609 GO:2001214
GL_000501	Galectin-4	P56470	Homo sapiens	9606	antibacterial peptide biosynthetic process carbohydrate binding cell adhesion collagen-containing extracellular matrix cytosol extracellular space galactoside binding plasma membrane	GO:0002780 GO:0005615 GO:0005829 GO:0005886 GO:0007155 GO:0016936 GO:0030246 GO:0062023
GL_000820	NKG2-C type II integral membrane protein	P26717	Homo sapiens	9606	MHC class I protein complex binding activating MHC class Ib receptor activity adaptive immune response carbohydrate binding cellular defense response external side of plasma membrane natural killer cell mediated immunity plasma membrane positive regulation of natural killer cell degranulation positive regulation of natural killer cell mediated cytotoxicity protein antigen binding receptor complex regulation of natural killer cell activation signal transduction stimulatory C-type lectin receptor signaling pathway transmembrane signaling receptor activity	GO:0002223 GO:0002228 GO:0002250 GO:0004888 GO:0005886 GO:0006968 GO:0007165 GO:0009897 GO:0023024 GO:0030246 GO:0032814 GO:0043235 GO:0043323 GO:0045954 GO:0062081 GO:1990405