GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	UniProt ID	Monosaccharide Specificities	Species	Taxonomy ID ▼	GO Labels	GO IDs
GL_002323	Intercellular adhesion molecule 1	P05362		Homo sapiens	9606	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell T cell antigen processing and presentation T cell extravasation adhesion of symbiont to host cell adhesion cell adhesion mediated by integrin cell surface cellular response to amyloid-beta cellular response to glucose stimulus cellular response to leukemia inhibitory factor collagen-containing extracellular matrix establishment of endothelial barrier external side of plasma membrane extracellular exosome extracellular space focal adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules immunological synapse integrin binding leukocyte cell-cell adhesion leukocyte migration membrane membrane raft membrane to membrane docking negative regulation of endothelial cell apoptotic process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors plasma membrane positive regulation of ERK1 and ERK2 cascade positive regulation of cellular extravasation receptor-mediated virion attachment to host cell regulation of leukocyte mediated cytotoxicity regulation of ruffle assembly signaling receptor activity transmembrane signaling receptor activity virus receptor activity	GO:0001618 GO:0001772 GO:0001910 GO:0002291 GO:0002457 GO:0002693 GO:0004888 GO:0005178 GO:0005615 GO:0005886 GO:0005925 GO:0007155 GO:0007157 GO:0007159 GO:0009897 GO:0009986 GO:0016020 GO:0022614 GO:0033627 GO:0038023 GO:0044406 GO:0045121 GO:0046813 GO:0050900 GO:0061028 GO:0062023 GO:0070062 GO:0070374 GO:0071333 GO:0072683 GO:1900027 GO:1902042 GO:1904646 GO:1990830 GO:2000352
GL_001174	Vesicular integral-membrane protein VIP36	Q12907		Homo sapiens	9606	COPII-coated ER to Golgi transport vesicle Golgi apparatus Golgi membrane carbohydrate binding cell surface endoplasmic reticulum membrane endoplasmic reticulum to Golgi vesicle-mediated transport endoplasmic reticulum-Golgi intermediate compartment endoplasmic reticulum-Golgi intermediate compartment membrane extracellular exosome extracellular space heat shock protein binding mannose binding metal ion binding plasma membrane positive regulation of phagocytosis protein transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	GO:0000139 GO:0005537 GO:0005615 GO:0005789 GO:0005793 GO:0005794 GO:0005886 GO:0006888 GO:0006890 GO:0009986 GO:0015031 GO:0030134 GO:0030246 GO:0031072 GO:0033116 GO:0046872 GO:0050766 GO:0070062
GL_000968	Protein FAM3A	P98173		Homo sapiens	9606	antifungal humoral response antimicrobial humoral immune response mediated by antimicrobial peptide carbohydrate binding extracellular space negative regulation of antifungal innate immune response	GO:0005615 GO:0019732 GO:0030246 GO:0061844 GO:1905035
GL_000768	Lymphocyte antigen 75	O60449		Homo sapiens	9606	carbohydrate binding endocytosis external side of plasma membrane extracellular exosome immune response inflammatory response plasma membrane signaling receptor activity	GO:0005886 GO:0006897 GO:0006954 GO:0006955 GO:0009897 GO:0030246 GO:0038023 GO:0070062
GL_001708	Maltase-glucoamylase	O43451		Homo sapiens	9606	alpha-1,4-glucosidase activity amylase activity apical plasma membrane carbohydrate binding catalytic activity dextrin catabolic process extracellular exosome ficolin-1-rich granule membrane glucan 1,4-alpha-glucosidase activity maltose alpha-glucosidase activity maltose catabolic process plasma membrane starch catabolic process tertiary granule membrane	GO:0000025 GO:0003824 GO:0004339 GO:0004558 GO:0005886 GO:0005983 GO:0016160 GO:0016324 GO:0030246 GO:0032450 GO:0070062 GO:0070821 GO:0101003 GO:1901027
GL_001415	Contactin-1	Q12860		Homo sapiens	9606	Notch signaling pathway axon axon guidance brain development carbohydrate binding cell adhesion cell-cell adhesion cell-cell adhesion mediator activity central nervous system myelin formation cerebellum development extracellular exosome gene expression locomotory behavior membrane plasma membrane positive regulation of gene expression positive regulation of neuron projection development positive regulation of sodium ion transport postsynaptic membrane presynaptic membrane side of membrane	GO:0005886 GO:0007155 GO:0007219 GO:0007411 GO:0007420 GO:0007626 GO:0010467 GO:0010628 GO:0010765 GO:0010976 GO:0016020 GO:0021549 GO:0030246 GO:0030424 GO:0032289 GO:0042734 GO:0045211 GO:0070062 GO:0098552 GO:0098609 GO:0098632
GL_001998	Collectin-12	Q5KU26		Homo sapiens	9606	carbohydrate mediated signaling cellular response to exogenous dsRNA collagen trimer collagen-containing extracellular matrix defense response defense response to bacterium endocytic vesicle membrane extracellular space galactose binding innate immune response low-density lipoprotein particle binding membrane metal ion binding pattern recognition receptor activity phagocytosis, recognition plasma membrane plasma membrane raft organization scavenger receptor activity toll-like receptor 3 signaling pathway	GO:0005044 GO:0005534 GO:0005581 GO:0005615 GO:0005886 GO:0006910 GO:0006952 GO:0009756 GO:0016020 GO:0030169 GO:0030666 GO:0034138 GO:0038187 GO:0042742 GO:0044857 GO:0045087 GO:0046872 GO:0062023 GO:0071360
GL_002045	Macrophage mannose receptor 1	P22897		Homo sapiens	9606	cargo receptor activity cell surface cellular response to interleukin-4 cellular response to lipopolysaccharide cellular response to type II interferon endosome membrane mannose binding plasma membrane receptor-mediated endocytosis signaling receptor activity transmembrane signaling receptor activity virus receptor activity	GO:0001618 GO:0004888 GO:0005537 GO:0005886 GO:0006898 GO:0009986 GO:0010008 GO:0038023 GO:0038024 GO:0071222 GO:0071346 GO:0071353
GL_001382	CD209 antigen	Q9NNX6	Man	Homo sapiens	9606	B cell adhesion adaptive immune response antigen processing and presentation carbohydrate binding cell surface cell-cell recognition cytoplasm endocytosis external side of plasma membrane extracellular region heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules host cell immune response innate immune response intracellular signal transduction intracellular transport of virus leukocyte cell-cell adhesion mannose binding membrane metal ion binding peptide antigen binding peptide antigen transport plasma membrane positive regulation of T cell proliferation positive regulation of viral life cycle regulation of T cell proliferation viral entry into host cell viral genome replication virion attachment to host cell virion binding virus receptor activity	GO:0001618 GO:0002250 GO:0005537 GO:0005576 GO:0005737 GO:0005886 GO:0006897 GO:0006955 GO:0007157 GO:0007159 GO:0009897 GO:0009986 GO:0009988 GO:0016020 GO:0019062 GO:0019079 GO:0019882 GO:0030246 GO:0035556 GO:0042102 GO:0042129 GO:0042605 GO:0043657 GO:0045087 GO:0046718 GO:0046790 GO:0046872 GO:0046968 GO:0075733 GO:0097323 GO:1903902
GL_002359	Pentraxin-related protein PTX3	P26022		Homo sapiens	9606	(1->3)-beta-D-glucan binding complement component C1q complex binding extracellular matrix extracellular matrix organization extracellular region extracellular space identical protein binding inflammatory response innate immune response negative regulation by host of viral exo-alpha-sialidase activity negative regulation by host of viral glycoprotein metabolic process negative regulation by host of viral process negative regulation of exo-alpha-sialidase activity negative regulation of glycoprotein metabolic process negative regulation of viral entry into host cell opsonization ovarian cumulus expansion positive regulation of nitric oxide biosynthetic process positive regulation of phagocytosis response to yeast specific granule lumen tertiary granule lumen virion binding	GO:0001550 GO:0001849 GO:0001872 GO:0001878 GO:0005576 GO:0005615 GO:0006954 GO:0008228 GO:0030198 GO:0031012 GO:0035580 GO:0042802 GO:0044793 GO:0044869 GO:0044871 GO:0045087 GO:0045429 GO:0046597 GO:0046790 GO:0050766 GO:1903016 GO:1903019 GO:1904724