GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	UniProt ID	Species	Taxonomy ID	GO Labels ▲	GO IDs
GL_001834	Signal transducer CD24	P24807	Mus musculus	10090	B cell apoptotic process B cell proliferation B cell receptor transport into membrane raft CD4-positive, alpha-beta T cell proliferation Hsp70 protein binding Hsp90 protein binding T cell costimulation T cell homeostatic proliferation apoptotic mitochondrial changes apoptotic nuclear changes apoptotic signaling pathway calcium-mediated signaling carbohydrate binding cell activation cell migration cell surface cell surface receptor signaling pathway chemokine receptor transport out of membrane raft cholesterol homeostasis ciliary membrane external side of plasma membrane glomerular parietal epithelial cell differentiation heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules homotypic cell-cell adhesion innate immune response integrin activation intracellular membrane-bounded organelle leukocyte cell-cell adhesion leukocyte migration involved in inflammatory response membrane membrane raft microvillus membrane motile cilium negative regulation of B cell proliferation negative regulation of T cell homeostatic proliferation negative regulation of erythrocyte aggregation negative regulation of erythrocyte clearance negative regulation of inflammatory response to wounding negative regulation of interleukin-6 production negative regulation of monocyte chemotactic protein-1 production negative regulation of neuroblast proliferation negative regulation of neurogenesis negative regulation of neuron differentiation negative regulation of transforming growth factor beta3 production negative regulation of tumor necrosis factor production neuroblast proliferation neuromuscular synaptic transmission neuron projection development plasma membrane podocyte differentiation positive regulation of B cell apoptotic process positive regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of MAP kinase activity positive regulation of T cell homeostatic proliferation positive regulation of T cell mediated immune response to tumor cell positive regulation of activated T cell proliferation positive regulation of alpha-beta T cell proliferation positive regulation of calcium-mediated signaling positive regulation of cell adhesion mediated by integrin positive regulation of cell-cell adhesion positive regulation of cell-cell adhesion mediated by integrin positive regulation of cytosolic calcium ion concentration positive regulation of inflammatory response to antigenic stimulus positive regulation of inflammatory response to wounding positive regulation of integrin activation positive regulation of nephron tubule epithelial cell differentiation positive regulation of neuron projection development positive regulation of peptidyl-tyrosine phosphorylation pre-B cell differentiation presynapse protein kinase binding protein tyrosine kinase activator activity regulation of B cell differentiation regulation of MAPK cascade regulation of cell-cell adhesion regulation of cell-cell adhesion mediated by integrin regulation of cytokine-mediated signaling pathway regulation of phosphorylation respiratory burst response to estrogen response to hypoxia response to molecule of bacterial origin synaptic vesicle endocytosis	GO:0001666 GO:0001775 GO:0001777 GO:0001783 GO:0001959 GO:0002237 GO:0002329 GO:0002523 GO:0002842 GO:0002863 GO:0002904 GO:0005886 GO:0007157 GO:0007159 GO:0007166 GO:0007204 GO:0007274 GO:0007405 GO:0007406 GO:0008637 GO:0009897 GO:0009986 GO:0010976 GO:0016020 GO:0016477 GO:0019722 GO:0019901 GO:0022407 GO:0022409 GO:0030246 GO:0030262 GO:0030296 GO:0030544 GO:0030889 GO:0031175 GO:0031295 GO:0031514 GO:0031528 GO:0032597 GO:0032600 GO:0032715 GO:0032720 GO:0032913 GO:0033622 GO:0033625 GO:0033630 GO:0033632 GO:0033634 GO:0034107 GO:0034109 GO:0034119 GO:0035739 GO:0042100 GO:0042103 GO:0042104 GO:0042325 GO:0042632 GO:0043231 GO:0043406 GO:0043408 GO:0043627 GO:0045087 GO:0045121 GO:0045577 GO:0045665 GO:0045730 GO:0046014 GO:0046641 GO:0048488 GO:0050731 GO:0050768 GO:0050850 GO:0051879 GO:0060170 GO:0071638 GO:0072112 GO:0072139 GO:0097190 GO:0098793 GO:0106015 GO:0106016 GO:2000563 GO:2000768
GL_001829	Sclerostin	Q9BQB4	Homo sapiens	9606	BMP binding BMP signaling pathway DNA-binding transcription factor binding Golgi apparatus canonical Wnt signaling pathway carbohydrate binding cellular response to parathyroid hormone stimulus extracellular region extracellular space heparin binding localization molecular function inhibitor activity negative regulation of BMP signaling pathway negative regulation of Wnt signaling pathway negative regulation of canonical Wnt signaling pathway negative regulation of ossification negative regulation of protein-containing complex assembly ossification positive regulation of DNA-templated transcription protein-containing complex response to mechanical stimulus	GO:0001503 GO:0005576 GO:0005615 GO:0005794 GO:0008201 GO:0009612 GO:0030178 GO:0030246 GO:0030279 GO:0030509 GO:0030514 GO:0031333 GO:0032991 GO:0036122 GO:0045893 GO:0051179 GO:0060070 GO:0071374 GO:0090090 GO:0140297 GO:0140678
GL_001831	Sclerostin	Q99P67	Rattus norvegicus	10116	BMP binding BMP signaling pathway DNA-binding transcription factor binding Golgi apparatus canonical Wnt signaling pathway carbohydrate binding cellular response to parathyroid hormone stimulus extracellular space heparin binding localization molecular function inhibitor activity negative regulation of BMP signaling pathway negative regulation of Wnt signaling pathway negative regulation of canonical Wnt signaling pathway negative regulation of ossification negative regulation of protein-containing complex assembly ossification positive regulation of DNA-templated transcription protein-containing complex response to mechanical stimulus	GO:0001503 GO:0005615 GO:0005794 GO:0008201 GO:0009612 GO:0030178 GO:0030246 GO:0030279 GO:0030509 GO:0030514 GO:0031333 GO:0032991 GO:0036122 GO:0045893 GO:0051179 GO:0060070 GO:0071374 GO:0090090 GO:0140297 GO:0140678
GL_001830	Sclerostin	Q99P68	Mus musculus	10090	BMP binding BMP signaling pathway DNA-binding transcription factor binding Golgi apparatus canonical Wnt signaling pathway carbohydrate binding cellular response to parathyroid hormone stimulus extracellular space heparin binding localization molecular function inhibitor activity negative regulation of BMP signaling pathway negative regulation of Wnt signaling pathway negative regulation of canonical Wnt signaling pathway negative regulation of ossification negative regulation of protein-containing complex assembly ossification positive regulation of DNA-templated transcription protein-containing complex response to mechanical stimulus	GO:0001503 GO:0005615 GO:0005794 GO:0008201 GO:0009612 GO:0030178 GO:0030246 GO:0030279 GO:0030509 GO:0030514 GO:0031333 GO:0032991 GO:0036122 GO:0045893 GO:0051179 GO:0060070 GO:0071374 GO:0090090 GO:0140297 GO:0140678
GL_002384	CD83 antigen	Q01151	Homo sapiens	9606	CD4-positive, alpha-beta T cell differentiation defense response external side of plasma membrane humoral immune response negative regulation of interleukin-4 production plasma membrane positive regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of interleukin-10 production positive regulation of interleukin-2 production response to organic cyclic compound signal transduction	GO:0005886 GO:0006952 GO:0006959 GO:0007165 GO:0009897 GO:0014070 GO:0032713 GO:0032733 GO:0032743 GO:0043367 GO:0043372
GL_000174	C-type lectin domain family 4 member A	Q9UMR7	Homo sapiens	9606	CD8-positive, alpha-beta T cell activation adaptive immune response antifungal innate immune response antigen processing and presentation of exogenous peptide antigen via MHC class I calcium ion binding carbohydrate binding cell adhesion cell surface receptor signaling pathway external side of plasma membrane mannose binding negative regulation of cytokine production negative regulation of tumor necrosis factor production plasma membrane plasmacytoid dendritic cell antigen processing and presentation transmembrane signaling receptor activity	GO:0001818 GO:0002250 GO:0002470 GO:0004888 GO:0005509 GO:0005537 GO:0005886 GO:0007155 GO:0007166 GO:0009897 GO:0030246 GO:0032720 GO:0036037 GO:0042590 GO:0061760
GL_000175	C-type lectin domain family 4 member A	Q67EQ0	Rattus norvegicus	10116	CD8-positive, alpha-beta T cell activation adaptive immune response antifungal innate immune response antigen processing and presentation of exogenous peptide antigen via MHC class I calcium ion binding carbohydrate binding defense response to fungus detection of yeast external side of plasma membrane innate immune response mannose binding negative regulation of cytokine production negative regulation of tumor necrosis factor production pattern recognition receptor activity plasmacytoid dendritic cell antigen processing and presentation positive regulation of T-helper 17 type immune response positive regulation of canonical NF-kappaB signal transduction positive regulation of cytokine production positive regulation of intracellular signal transduction positive regulation of peptidyl-tyrosine phosphorylation response to yeast stimulatory C-type lectin receptor signaling pathway	GO:0001818 GO:0001819 GO:0001878 GO:0001879 GO:0002223 GO:0002250 GO:0002470 GO:0005509 GO:0005537 GO:0009897 GO:0030246 GO:0032720 GO:0036037 GO:0038187 GO:0042590 GO:0043123 GO:0045087 GO:0050731 GO:0050832 GO:0061760 GO:1902533 GO:2000318
GL_000173	C-type lectin domain family 4 member A	Q9QZ15	Mus musculus	10090	CD8-positive, alpha-beta T cell activation adaptive immune response antifungal innate immune response antigen processing and presentation of exogenous peptide antigen via MHC class I calcium ion binding carbohydrate binding external side of plasma membrane mannose binding membrane negative regulation of cytokine production negative regulation of tumor necrosis factor production plasmacytoid dendritic cell antigen processing and presentation	GO:0001818 GO:0002250 GO:0002470 GO:0005509 GO:0005537 GO:0009897 GO:0016020 GO:0030246 GO:0032720 GO:0036037 GO:0042590 GO:0061760
GL_000817	NKG2-A/NKG2-B type II integral membrane protein	P26715	Homo sapiens	9606	CD8-positive, gamma-delta intraepithelial T cell differentiation HLA-E specific inhibitory MHC class Ib receptor activity MHC class I protein complex binding adaptive immune response carbohydrate binding cell surface receptor signaling pathway external side of plasma membrane inhibitory MHC class Ib receptor activity innate immune response natural killer cell inhibitory signaling pathway negative regulation of T cell mediated cytotoxicity negative regulation of natural killer cell mediated cytotoxicity plasma membrane positive regulation of natural killer cell mediated cytotoxicity receptor complex regulation of natural killer cell activation stimulatory C-type lectin receptor signaling pathway transmembrane signaling receptor activity	GO:0001915 GO:0002223 GO:0002250 GO:0002305 GO:0002769 GO:0004888 GO:0005886 GO:0007166 GO:0009897 GO:0023024 GO:0030246 GO:0032814 GO:0043235 GO:0045087 GO:0045953 GO:0045954 GO:0062080 GO:0062082
GL_000815	NKG2-A/NKG2-B type II integral membrane protein	Q95MI5	Pan troglodytes	9598	CD8-positive, gamma-delta intraepithelial T cell differentiation HLA-E specific inhibitory MHC class Ib receptor activity MHC class I protein complex binding adaptive immune response carbohydrate binding external side of plasma membrane innate immune response natural killer cell inhibitory signaling pathway negative regulation of T cell mediated cytotoxicity negative regulation of natural killer cell mediated cytotoxicity plasma membrane positive regulation of natural killer cell mediated cytotoxicity receptor complex stimulatory C-type lectin receptor signaling pathway transmembrane signaling receptor activity	GO:0001915 GO:0002223 GO:0002250 GO:0002305 GO:0002769 GO:0004888 GO:0005886 GO:0009897 GO:0023024 GO:0030246 GO:0043235 GO:0045087 GO:0045953 GO:0045954 GO:0062082