GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	UniProt ID	Species	Taxonomy ID ▼	GO Labels	GO IDs
GL_000178	C-type lectin domain family 4 member D	Q8WXI8	Homo sapiens	9606	Fc-gamma receptor signaling pathway T cell differentiation involved in immune response adaptive immune response antifungal innate immune response carbohydrate binding defense response to bacterium external side of plasma membrane ficolin-1-rich granule membrane immunoglobulin receptor binding mannose binding metal ion binding pattern recognition receptor activity plasma membrane positive regulation of canonical NF-kappaB signal transduction positive regulation of myeloid dendritic cell activation specific granule membrane tertiary granule membrane	GO:0002250 GO:0002292 GO:0005537 GO:0005886 GO:0009897 GO:0030246 GO:0030887 GO:0034987 GO:0035579 GO:0038094 GO:0038187 GO:0042742 GO:0043123 GO:0046872 GO:0061760 GO:0070821 GO:0101003
GL_000082	B-cell receptor CD22	P20273	Homo sapiens	9606	B cell activation CD4 receptor binding IgM binding carbohydrate binding cell adhesion cell surface cytoplasm early endosome external side of plasma membrane extracellular exosome membrane negative regulation of B cell receptor signaling pathway negative regulation of calcium-mediated signaling negative regulation of immunoglobulin production neuronal cell body membrane plasma membrane protein phosphatase binding recycling endosome regulation of B cell proliferation regulation of endocytosis regulation of immune response sialic acid binding signaling receptor binding	GO:0001791 GO:0002638 GO:0005102 GO:0005737 GO:0005769 GO:0005886 GO:0007155 GO:0009897 GO:0009986 GO:0016020 GO:0019903 GO:0030100 GO:0030246 GO:0030888 GO:0032809 GO:0033691 GO:0042113 GO:0042609 GO:0050776 GO:0050849 GO:0050859 GO:0055037 GO:0070062
GL_001781	Protein AMBP	P02760	Homo sapiens	9606	IgA binding blood microparticle calcium channel inhibitor activity calcium oxalate binding carbohydrate binding cell adhesion cell surface collagen-containing extracellular matrix cytosol endoplasmic reticulum extracellular exosome extracellular region extracellular space female pregnancy heme binding heme catabolic process mitochondrial inner membrane negative regulation of JNK cascade negative regulation of immune response nuclear membrane oxidoreductase activity plasma membrane protein homodimerization activity serine-type endopeptidase inhibitor activity	GO:0004867 GO:0005576 GO:0005615 GO:0005743 GO:0005783 GO:0005829 GO:0005886 GO:0007155 GO:0007565 GO:0009986 GO:0016491 GO:0019855 GO:0019862 GO:0020037 GO:0030246 GO:0031965 GO:0042167 GO:0042803 GO:0046329 GO:0046904 GO:0050777 GO:0062023 GO:0070062 GO:0072562
GL_000180	C-type lectin domain family 4 member E	Q9ULY5	Homo sapiens	9606	Fc-gamma receptor signaling pathway T cell differentiation involved in immune response antifungal innate immune response calcium ion binding carbohydrate binding cell projection defense response to bacterium external side of plasma membrane glycolipid binding innate immune response membrane pattern recognition receptor activity pattern recognition receptor signaling pathway phagocytic cup phagocytic vesicle membrane plasma membrane positive regulation of cytokine production	GO:0001819 GO:0001891 GO:0002221 GO:0002292 GO:0005509 GO:0005886 GO:0009897 GO:0016020 GO:0030246 GO:0030670 GO:0038094 GO:0038187 GO:0042742 GO:0042995 GO:0045087 GO:0051861 GO:0061760
GL_001068	Regenerating islet-derived protein 3-alpha	Q06141	Homo sapiens	9606	acute-phase response antimicrobial humoral immune response mediated by antimicrobial peptide carbohydrate binding cytoplasm extracellular region extracellular space heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules hormone activity identical protein binding negative regulation of inflammatory response negative regulation of inflammatory response to wounding negative regulation of keratinocyte differentiation oligosaccharide binding peptidoglycan binding positive regulation of cell population proliferation positive regulation of detection of glucose positive regulation of keratinocyte proliferation positive regulation of wound healing response to peptide hormone response to symbiotic bacterium response to wounding signaling receptor activity	GO:0005179 GO:0005576 GO:0005615 GO:0005737 GO:0006953 GO:0007157 GO:0008284 GO:0009609 GO:0009611 GO:0010838 GO:0030246 GO:0038023 GO:0042802 GO:0042834 GO:0043434 GO:0045617 GO:0050728 GO:0061844 GO:0070492 GO:0090303 GO:0106015 GO:2000972
GL_000897	Polypeptide N-acetylgalactosaminyltransferase 13	Q8IUC8	Homo sapiens	9606	Golgi apparatus Golgi membrane O-glycan processing carbohydrate binding metal ion binding polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation protein O-linked glycosylation via serine protein O-linked glycosylation via threonine	GO:0000139 GO:0004653 GO:0005794 GO:0006493 GO:0016266 GO:0018242 GO:0018243 GO:0030246 GO:0046872
GL_001629	Glucokinase regulatory protein	Q14397	Homo sapiens	9606	carbohydrate binding carbohydrate derivative metabolic process carbohydrate metabolic process cytoplasm cytosol enzyme binding enzyme inhibitor activity fructose-6-phosphate binding glucose homeostasis glucose sensor activity kinase inhibitor activity mitochondrion negative regulation of glucokinase activity nucleoplasm protein import into nucleus response to fructose response to glucose triglyceride homeostasis urate metabolic process	GO:0004857 GO:0005654 GO:0005737 GO:0005739 GO:0005829 GO:0005975 GO:0006606 GO:0009749 GO:0009750 GO:0019210 GO:0019899 GO:0030246 GO:0033132 GO:0042593 GO:0046415 GO:0070095 GO:0070328 GO:0141089 GO:1901135
GL_001891	Zona pellucida sperm-binding protein 3	P21754	Homo sapiens	9606	acrosin binding binding of sperm to zona pellucida blastocyst formation carbohydrate binding collagen-containing extracellular matrix egg coat egg coat formation extracellular matrix extracellular matrix structural constituent extracellular region extracellular space humoral immune response mediated by circulating immunoglobulin identical protein binding negative regulation of DNA-templated transcription negative regulation of binding of sperm to zona pellucida oocyte development plasma membrane positive regulation of DNA-templated transcription positive regulation of T cell proliferation positive regulation of acrosomal vesicle exocytosis positive regulation of acrosome reaction positive regulation of antral ovarian follicle growth positive regulation of humoral immune response positive regulation of inflammatory response positive regulation of interleukin-4 production positive regulation of leukocyte migration positive regulation of ovarian follicle development positive regulation of type II interferon production positive regulation of type IV hypersensitivity receptor ligand activity structural constituent of egg coat	GO:0001809 GO:0001825 GO:0002455 GO:0002687 GO:0002922 GO:0005201 GO:0005576 GO:0005615 GO:0005886 GO:0007339 GO:0030246 GO:0031012 GO:0032190 GO:0032729 GO:0032753 GO:0035803 GO:0035804 GO:0035805 GO:0042102 GO:0042802 GO:0045892 GO:0045893 GO:0048018 GO:0048599 GO:0050729 GO:0062023 GO:2000344 GO:2000360 GO:2000368 GO:2000386 GO:2000388
GL_000020	Adhesion G protein-coupled receptor L2	O95490	Homo sapiens	9606	G protein-coupled receptor activity G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway carbohydrate binding cell surface receptor signaling pathway latrotoxin receptor activity membrane	GO:0004930 GO:0007166 GO:0007186 GO:0007189 GO:0016020 GO:0016524 GO:0030246
GL_001465	ER membrane protein complex subunit 7	Q9NPA0	Homo sapiens	9606	EMC complex carbohydrate binding endoplasmic reticulum membrane membrane protein insertion into ER membrane by stop-transfer membrane-anchor sequence tail-anchored membrane protein insertion into ER membrane	GO:0005789 GO:0016020 GO:0030246 GO:0045050 GO:0071816 GO:0072546