GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	UniProt ID	Species	Taxonomy ID	GO Labels	GO IDs ▲
GL_000271	Calreticulin	P14211	Mus musculus	10090	MHC class I peptide loading complex acrosomal vesicle calcium ion binding carbohydrate binding cardiac muscle cell differentiation cell surface cellular response to electrical stimulus cellular response to lithium ion cellular response to organic substance cellular response to virus cellular senescence collagen-containing extracellular matrix complement component C1q complex binding cortical actin cytoskeleton organization cortical granule cytolytic granule cytoplasm cytosol endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum quality control compartment external side of plasma membrane extracellular region extracellular space hormone binding integrin binding iron ion binding mRNA binding membrane negative regulation of DNA-templated transcription negative regulation of intracellular steroid hormone receptor signaling pathway negative regulation of neuron differentiation negative regulation of retinoic acid receptor signaling pathway negative regulation of transcription by RNA polymerase II negative regulation of translation negative regulation of trophoblast cell migration nuclear androgen receptor binding nuclear envelope nuclear export signal receptor activity nucleus obsolete selective autophagy peptide antigen assembly with MHC class I protein complex peptide binding perinuclear region of cytoplasm phagocytic vesicle polysome positive regulation of cell cycle positive regulation of cell population proliferation positive regulation of dendritic cell chemotaxis positive regulation of endothelial cell migration positive regulation of gene expression positive regulation of non-canonical NF-kappaB signal transduction positive regulation of phagocytosis positive regulation of substrate adhesion-dependent cell spreading protein export from nucleus protein folding protein localization to nucleus protein stabilization protein-containing complex regulation of meiotic nuclear division response to estradiol response to glycoside response to testosterone response to xenobiotic stimulus sarcoplasmic reticulum sarcoplasmic reticulum lumen smooth endoplasmic reticulum spermatogenesis ubiquitin protein ligase binding ubiquitin-dependent ERAD pathway unfolded protein binding	GO:0000122 GO:0001669 GO:0001849 GO:0002502 GO:0003729 GO:0005049 GO:0005178 GO:0005506 GO:0005509 GO:0005576 GO:0005615 GO:0005634 GO:0005635 GO:0005737 GO:0005783 GO:0005788 GO:0005789 GO:0005790 GO:0005829 GO:0005844 GO:0006457 GO:0006611 GO:0007283 GO:0008284 GO:0009410 GO:0009897 GO:0009986 GO:0010595 GO:0010628 GO:0016020 GO:0016529 GO:0017148 GO:0030246 GO:0030433 GO:0030866 GO:0031625 GO:0032355 GO:0032991 GO:0033018 GO:0033144 GO:0033574 GO:0034504 GO:0040020 GO:0042277 GO:0042562 GO:0042824 GO:0044194 GO:0044322 GO:0045335 GO:0045665 GO:0045787 GO:0045892 GO:0048387 GO:0048471 GO:0050681 GO:0050766 GO:0050821 GO:0051082 GO:0055007 GO:0060473 GO:0061912 GO:0062023 GO:0071257 GO:0071285 GO:0071310 GO:0090398 GO:0098586 GO:1900026 GO:1901164 GO:1901224 GO:1903416 GO:2000510
GL_000269	Calreticulin	P18418	Rattus norvegicus	10116	MHC class I peptide loading complex acrosomal vesicle calcium ion binding carbohydrate binding cardiac muscle cell differentiation cell surface cellular response to electrical stimulus cellular response to lithium ion cellular response to organic substance cellular response to virus cellular senescence collagen-containing extracellular matrix complement component C1q complex binding cortical actin cytoskeleton organization cortical granule cytolytic granule cytoplasm cytosol endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum quality control compartment external side of plasma membrane extracellular space hormone binding integrin binding iron ion binding mRNA binding membrane negative regulation of DNA-templated transcription negative regulation of intracellular steroid hormone receptor signaling pathway negative regulation of neuron differentiation negative regulation of retinoic acid receptor signaling pathway negative regulation of transcription by RNA polymerase II negative regulation of translation negative regulation of trophoblast cell migration nuclear androgen receptor binding nuclear envelope nuclear export signal receptor activity nucleus obsolete selective autophagy peptide antigen assembly with MHC class I protein complex peptide binding perinuclear region of cytoplasm polysome positive regulation of cell cycle positive regulation of cell population proliferation positive regulation of dendritic cell chemotaxis positive regulation of endothelial cell migration positive regulation of gene expression positive regulation of non-canonical NF-kappaB signal transduction positive regulation of phagocytosis positive regulation of substrate adhesion-dependent cell spreading protein export from nucleus protein folding protein localization to nucleus protein stabilization protein-containing complex regulation of meiotic nuclear division response to estradiol response to glycoside response to organic substance response to testosterone response to xenobiotic stimulus sarcoplasmic reticulum sarcoplasmic reticulum lumen smooth endoplasmic reticulum spermatogenesis ubiquitin protein ligase binding ubiquitin-dependent ERAD pathway unfolded protein binding	GO:0000122 GO:0001669 GO:0001849 GO:0002502 GO:0003729 GO:0005049 GO:0005178 GO:0005506 GO:0005509 GO:0005615 GO:0005634 GO:0005635 GO:0005737 GO:0005783 GO:0005788 GO:0005789 GO:0005790 GO:0005829 GO:0005844 GO:0006457 GO:0006611 GO:0007283 GO:0008284 GO:0009410 GO:0009897 GO:0009986 GO:0010033 GO:0010595 GO:0010628 GO:0016020 GO:0016529 GO:0017148 GO:0030246 GO:0030433 GO:0030866 GO:0031625 GO:0032355 GO:0032991 GO:0033018 GO:0033144 GO:0033574 GO:0034504 GO:0040020 GO:0042277 GO:0042562 GO:0042824 GO:0044194 GO:0044322 GO:0045665 GO:0045787 GO:0045892 GO:0048387 GO:0048471 GO:0050681 GO:0050766 GO:0050821 GO:0051082 GO:0055007 GO:0060473 GO:0061912 GO:0062023 GO:0071257 GO:0071285 GO:0071310 GO:0090398 GO:0098586 GO:1900026 GO:1901164 GO:1901224 GO:1903416 GO:2000510
GL_000262	Calreticulin	P28491	Sus scrofa	9823	MHC class I peptide loading complex calcium ion binding carbohydrate binding cellular senescence complement component C1q complex binding cortical actin cytoskeleton organization cortical granule cytolytic granule cytosol endoplasmic reticulum membrane endoplasmic reticulum quality control compartment external side of plasma membrane extracellular space integrin binding mRNA binding negative regulation of intracellular steroid hormone receptor signaling pathway negative regulation of neuron differentiation negative regulation of retinoic acid receptor signaling pathway negative regulation of transcription by RNA polymerase II negative regulation of translation negative regulation of trophoblast cell migration nuclear androgen receptor binding nuclear envelope nuclear export signal receptor activity peptide antigen assembly with MHC class I protein complex perinuclear region of cytoplasm polysome positive regulation of cell cycle positive regulation of cell population proliferation positive regulation of dendritic cell chemotaxis positive regulation of endothelial cell migration positive regulation of gene expression positive regulation of non-canonical NF-kappaB signal transduction positive regulation of phagocytosis positive regulation of substrate adhesion-dependent cell spreading protein export from nucleus protein folding protein localization to nucleus protein stabilization regulation of meiotic nuclear division sarcoplasmic reticulum lumen ubiquitin protein ligase binding ubiquitin-dependent ERAD pathway unfolded protein binding	GO:0000122 GO:0001849 GO:0002502 GO:0003729 GO:0005049 GO:0005178 GO:0005509 GO:0005615 GO:0005635 GO:0005789 GO:0005829 GO:0005844 GO:0006457 GO:0006611 GO:0008284 GO:0009897 GO:0010595 GO:0010628 GO:0017148 GO:0030246 GO:0030433 GO:0030866 GO:0031625 GO:0033018 GO:0033144 GO:0034504 GO:0040020 GO:0042824 GO:0044194 GO:0044322 GO:0045665 GO:0045787 GO:0048387 GO:0048471 GO:0050681 GO:0050766 GO:0050821 GO:0051082 GO:0060473 GO:0090398 GO:1900026 GO:1901164 GO:1901224 GO:2000510
GL_000287	Calreticulin	Q4R6K8	Macaca fascicularis	9541	MHC class I peptide loading complex calcium ion binding carbohydrate binding cell surface cellular senescence complement component C1q complex binding cortical granule cytolytic granule cytosol extracellular space integrin binding mRNA binding negative regulation of intracellular steroid hormone receptor signaling pathway negative regulation of neuron differentiation negative regulation of retinoic acid receptor signaling pathway negative regulation of transcription by RNA polymerase II negative regulation of translation negative regulation of trophoblast cell migration nuclear androgen receptor binding nuclear envelope nuclear export signal receptor activity perinuclear region of cytoplasm polysome positive regulation of cell cycle positive regulation of cell population proliferation positive regulation of dendritic cell chemotaxis positive regulation of endothelial cell migration positive regulation of substrate adhesion-dependent cell spreading protein export from nucleus protein folding protein localization to nucleus protein stabilization sarcoplasmic reticulum lumen ubiquitin protein ligase binding unfolded protein binding	GO:0000122 GO:0001849 GO:0003729 GO:0005049 GO:0005178 GO:0005509 GO:0005615 GO:0005635 GO:0005829 GO:0005844 GO:0006457 GO:0006611 GO:0008284 GO:0009986 GO:0010595 GO:0017148 GO:0030246 GO:0031625 GO:0033018 GO:0033144 GO:0034504 GO:0042824 GO:0044194 GO:0045665 GO:0045787 GO:0048387 GO:0048471 GO:0050681 GO:0050821 GO:0051082 GO:0060473 GO:0090398 GO:1900026 GO:1901164 GO:2000510
GL_002364	Flocculation protein FLO1	P32768	Saccharomyces cerevisiae S288C	559292	cell periphery extracellular region flocculation fungal-type cell wall mannose binding plasma membrane side of membrane	GO:0000128 GO:0005537 GO:0005576 GO:0005886 GO:0009277 GO:0071944 GO:0098552
GL_002368	Flocculation protein FLO5	P38894	Saccharomyces cerevisiae S288C	559292	cell periphery cell-substrate adhesion extracellular region flocculation fungal-type cell wall mannose binding side of membrane	GO:0000128 GO:0005537 GO:0005576 GO:0009277 GO:0031589 GO:0071944 GO:0098552
GL_002122	Flocculin	B3IUA8	Saccharomyces pastorianus	27292	flocculation metal ion binding side of membrane	GO:0000128 GO:0046872 GO:0098552
GL_001229	Alpha-mannosidase 2	Q9LFR0	Arabidopsis thaliana	3702	Golgi apparatus Golgi cis cisterna Golgi membrane alpha-mannosidase activity carbohydrate binding endosome hyperosmotic salinity response mannose metabolic process mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity metal ion binding protein N-linked glycosylation trans-Golgi network	GO:0000137 GO:0000139 GO:0004559 GO:0004572 GO:0005768 GO:0005794 GO:0005802 GO:0006013 GO:0006487 GO:0030246 GO:0042538 GO:0046872
GL_002052	Protein EMP47	P43555	Saccharomyces cerevisiae S288C	559292	COPII-coated ER to Golgi transport vesicle Golgi membrane carbohydrate derivative binding endoplasmic reticulum membrane endoplasmic reticulum to Golgi vesicle-mediated transport endoplasmic reticulum-Golgi intermediate compartment fungal-type vacuole membrane mannose binding	GO:0000139 GO:0000329 GO:0005537 GO:0005789 GO:0005793 GO:0006888 GO:0030134 GO:0097367
GL_000876	Polycystin-1	P98161	Homo sapiens	9606	Golgi apparatus Golgi membrane Golgi-associated vesicle membrane Wnt receptor activity anatomical structure morphogenesis basolateral plasma membrane branching morphogenesis of an epithelial tube calcium channel activity calcium channel complex calcium ion transmembrane transport calcium ion transport calcium-independent cell-matrix adhesion carbohydrate binding cartilage condensation cartilage development cation channel complex cell surface cell-cell signaling by wnt cell-matrix adhesion ciliary membrane cilium cytoplasm detection of mechanical stimulus digestive tract development embryonic placenta development endoplasmic reticulum establishment of epithelial cell polarity extracellular exosome genitalia development heart development homophilic cell adhesion via plasma membrane adhesion molecules in utero embryonic development kidney development lateral plasma membrane liver development lung epithelium development lymph vessel morphogenesis membrane mesonephric duct development mesonephric tubule development metanephric ascending thin limb development metanephric collecting duct development metanephric distal tubule morphogenesis metanephric proximal tubule development motile cilium neural tube development nucleus peptidyl-serine phosphorylation placenta blood vessel development plasma membrane polycystin complex positive regulation of cytosolic calcium ion concentration positive regulation of transcription by RNA polymerase II protein domain specific binding protein export from nucleus protein heterotetramerization protein kinase binding receptor signaling pathway via JAK-STAT regulation of G1/S transition of mitotic cell cycle regulation of cell adhesion regulation of cell cycle regulation of mitotic spindle organization regulation of proteasomal protein catabolic process response to fluid shear stress skin development spinal cord development transcription regulator inhibitor activity transmembrane transporter binding	GO:0000139 GO:0001502 GO:0001701 GO:0001822 GO:0001889 GO:0001892 GO:0002133 GO:0005262 GO:0005634 GO:0005737 GO:0005783 GO:0005794 GO:0005886 GO:0005929 GO:0006611 GO:0006816 GO:0007156 GO:0007160 GO:0007161 GO:0007204 GO:0007259 GO:0007507 GO:0009653 GO:0009986 GO:0016020 GO:0016323 GO:0016328 GO:0018105 GO:0019901 GO:0019904 GO:0021510 GO:0021915 GO:0030155 GO:0030246 GO:0030660 GO:0031514 GO:0034405 GO:0034703 GO:0034704 GO:0036303 GO:0042813 GO:0043588 GO:0044325 GO:0045944 GO:0048565 GO:0048754 GO:0048806 GO:0050982 GO:0051216 GO:0051290 GO:0051726 GO:0060170 GO:0060236 GO:0060428 GO:0060674 GO:0061136 GO:0070062 GO:0070588 GO:0072164 GO:0072177 GO:0072205 GO:0072218 GO:0072237 GO:0072287 GO:0090162 GO:0140416 GO:0198738 GO:2000045