GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	UniProt ID	Species ▲	Taxonomy ID	GO Labels	GO IDs
GL_000179	C-type lectin domain family 4 member D	Q69FH1	Rattus norvegicus	10116	Fc-gamma receptor signaling pathway T cell differentiation involved in immune response adaptive immune response antifungal innate immune response carbohydrate binding defense response to bacterium external side of plasma membrane immunoglobulin receptor binding innate immune response mannose binding metal ion binding pattern recognition receptor activity plasma membrane positive regulation of canonical NF-kappaB signal transduction positive regulation of myeloid dendritic cell activation	GO:0002250 GO:0002292 GO:0005537 GO:0005886 GO:0009897 GO:0030246 GO:0030887 GO:0034987 GO:0038094 GO:0038187 GO:0042742 GO:0043123 GO:0045087 GO:0046872 GO:0061760
GL_000614	Killer cell lectin-like receptor subfamily B member 1A	P27471	Rattus norvegicus	10116	carbohydrate binding cell surface plasma membrane regulation of natural killer cell mediated cytotoxicity signaling receptor activity	GO:0005886 GO:0009986 GO:0030246 GO:0038023 GO:0042269
GL_000804	Natural killer cells antigen CD94	O35778	Rattus norvegicus	10116	HLA-E specific inhibitory MHC class Ib receptor activity MHC class I protein complex binding MHC class Ib protein binding, via antigen binding groove adaptive immune response carbohydrate binding external side of plasma membrane natural killer cell mediated immunity negative regulation of T cell mediated cytotoxicity negative regulation of natural killer cell mediated cytotoxicity plasma membrane positive regulation of natural killer cell mediated cytotoxicity protein antigen binding receptor complex stimulatory C-type lectin receptor signaling pathway transmembrane signaling receptor activity	GO:0001915 GO:0002223 GO:0002228 GO:0002250 GO:0004888 GO:0005886 GO:0009897 GO:0023024 GO:0023030 GO:0030246 GO:0043235 GO:0045953 GO:0045954 GO:0062082 GO:1990405
GL_001823	Ribose-phosphate pyrophosphokinase 1	P60892	Rattus norvegicus	10116	5-phosphoribose 1-diphosphate biosynthetic process ADP binding AMP binding AMP biosynthetic process ATP binding GDP binding animal organ regeneration carbohydrate binding cytoplasm cytosol hypoxanthine biosynthetic process identical protein binding kinase activity magnesium ion binding nervous system development pentose-phosphate shunt phosphorylation protein homodimerization activity protein-containing complex purine nucleobase metabolic process purine nucleotide biosynthetic process ribose phosphate diphosphokinase activity ribose phosphate diphosphokinase complex urate biosynthetic process	GO:0000287 GO:0002189 GO:0004749 GO:0005524 GO:0005737 GO:0005829 GO:0006015 GO:0006098 GO:0006144 GO:0006164 GO:0006167 GO:0007399 GO:0016208 GO:0016301 GO:0016310 GO:0019003 GO:0030246 GO:0031100 GO:0032991 GO:0034418 GO:0042802 GO:0042803 GO:0043531 GO:0046101
GL_000899	Polypeptide N-acetylgalactosaminyltransferase 13	Q6UE39	Rattus norvegicus	10116	Golgi apparatus Golgi membrane carbohydrate binding metal ion binding polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation protein O-linked glycosylation via serine protein O-linked glycosylation via threonine	GO:0000139 GO:0004653 GO:0005794 GO:0006493 GO:0018242 GO:0018243 GO:0030246 GO:0046872
GL_001843	Sucrase-isomaltase, intestinal	P23739	Rattus norvegicus	10116	alpha-1,4-glucosidase activity apical plasma membrane beta-fructofuranosidase activity brush border carbohydrate binding membrane oligo-1,6-glucosidase activity response to fructose response to glucocorticoid response to insulin response to nutrient response to starvation response to sucrose response to vitamin A sucrose alpha-glucosidase activity sucrose catabolic process	GO:0004558 GO:0004564 GO:0004574 GO:0004575 GO:0005903 GO:0005987 GO:0007584 GO:0009744 GO:0009750 GO:0016020 GO:0016324 GO:0030246 GO:0032868 GO:0033189 GO:0042594 GO:0051384
GL_002058	Protein ERGIC-53-like	Q5FB95	Rattus norvegicus	10116	COPII-coated ER to Golgi transport vesicle Golgi membrane endoplasmic reticulum membrane endoplasmic reticulum to Golgi vesicle-mediated transport endoplasmic reticulum-Golgi intermediate compartment endoplasmic reticulum-Golgi intermediate compartment membrane mannose binding	GO:0000139 GO:0005537 GO:0005789 GO:0005793 GO:0006888 GO:0030134 GO:0033116
GL_001171	Versican core protein (Fragments)	Q9ERB4	Rattus norvegicus	10116	axon regeneration calcium ion binding carbohydrate binding cell adhesion cell surface central nervous system development collagen-containing extracellular matrix extracellular matrix extracellular region extracellular space glial cell differentiation glial cell migration heart development hyaluronic acid binding interphotoreceptor matrix low-density lipoprotein particle binding perineuronal net photoreceptor outer segment positive regulation of neuroblast proliferation protein phosphatase binding skeletal system development synapse ureteric bud development	GO:0001501 GO:0001657 GO:0001750 GO:0002052 GO:0005509 GO:0005540 GO:0005576 GO:0005615 GO:0007155 GO:0007417 GO:0007507 GO:0008347 GO:0009986 GO:0010001 GO:0019903 GO:0030169 GO:0030246 GO:0031012 GO:0031103 GO:0033165 GO:0045202 GO:0062023 GO:0072534
GL_001678	Laforin	Q91XQ2	Rattus norvegicus	10116	L-glutamate transmembrane transport Wnt signaling pathway autophagosome assembly autophagy calcium ion transport carbohydrate binding carbohydrate phosphatase activity carbohydrate phosphorylation cytoplasm cytoplasmic side of endoplasmic reticulum membrane cytoplasmic side of rough endoplasmic reticulum membrane cytosol dendrite dephosphorylation glial cell proliferation glycogen (starch) synthase activity glycogen binding glycogen biosynthetic process glycogen metabolic process habituation identical protein binding macromolecule metabolic process mitochondrion organization myosin phosphatase activity negative regulation of TOR signaling negative regulation of cell cycle negative regulation of gene expression negative regulation of peptidyl-serine phosphorylation nervous system development nucleus perikaryon phosphatase activity phosphoprotein phosphatase activity plasma membrane polysaccharide binding positive regulation of macroautophagy proteasome-mediated ubiquitin-dependent protein catabolic process protein homodimerization activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activity protein tyrosine/serine/threonine phosphatase activity regulation of cell growth regulation of gene expression regulation of phosphorylation regulation of proteasomal protein catabolic process regulation of protein import into nucleus regulation of protein localization to plasma membrane regulation of protein phosphorylation regulation of protein ubiquitination starch binding	GO:0000045 GO:0001558 GO:0001932 GO:0004373 GO:0004721 GO:0004722 GO:0004725 GO:0005634 GO:0005737 GO:0005829 GO:0005886 GO:0005977 GO:0005978 GO:0006816 GO:0006914 GO:0007005 GO:0007399 GO:0008138 GO:0010468 GO:0010629 GO:0014009 GO:0015813 GO:0016055 GO:0016239 GO:0016311 GO:0016791 GO:0017018 GO:0019203 GO:0030246 GO:0030247 GO:0030425 GO:0031396 GO:0032007 GO:0033137 GO:0042306 GO:0042325 GO:0042802 GO:0042803 GO:0043161 GO:0043170 GO:0043204 GO:0045786 GO:0046835 GO:0046959 GO:0061136 GO:0098554 GO:0098556 GO:1903076 GO:2001069 GO:2001070
GL_002329	Mannose-binding protein C	P08661	Rattus norvegicus	10116	antiviral innate immune response calcium ion binding calcium-dependent protein binding cell surface pattern recognition receptor signaling pathway collagen trimer complement activation, classical pathway complement activation, lectin pathway defense response to Gram-positive bacterium extracellular space galactose binding identical protein binding innate immune response killing by host of symbiont cells mannose binding multivesicular body negative regulation of viral process phosphatidylinositol-4-phosphate binding positive regulation of complement activation positive regulation of opsonization positive regulation of phagocytosis positive regulation of protein processing protease binding protein self-association protein-containing complex proteolysis serine-type endopeptidase complex signaling receptor binding surfactant homeostasis	GO:0001867 GO:0002020 GO:0002752 GO:0005102 GO:0005509 GO:0005534 GO:0005537 GO:0005581 GO:0005615 GO:0005771 GO:0006508 GO:0006958 GO:0010954 GO:0032991 GO:0042802 GO:0043129 GO:0043621 GO:0045087 GO:0045917 GO:0048306 GO:0048525 GO:0050766 GO:0050830 GO:0051873 GO:0070273 GO:0140374 GO:1903028 GO:1905370