GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	UniProt ID	Species	Taxonomy ID	GO Labels ▼	GO IDs
GL_000052	Aggrecan core protein	P07897	Rattus norvegicus	10116	GABA-ergic synapse basement membrane calcium ion binding carbohydrate binding cartilage condensation cell adhesion cellular response to growth factor stimulus central nervous system development chondroblast differentiation chondrocyte development collagen fibril organization extracellular matrix extracellular space glial cell differentiation glutamatergic synapse heart development hyaluronic acid binding negative regulation of cell migration neuronal cell body ossification perineuronal net perisynaptic extracellular matrix positive regulation of neuroblast proliferation proteoglycan biosynthetic process response to acidic pH response to glucose response to gravity response to mechanical stimulus response to organic cyclic compound response to xenobiotic stimulus skeletal system development spinal cord development synapse	GO:0001501 GO:0001502 GO:0001503 GO:0002052 GO:0002063 GO:0005509 GO:0005540 GO:0005604 GO:0005615 GO:0007155 GO:0007417 GO:0007507 GO:0009410 GO:0009612 GO:0009629 GO:0009749 GO:0010001 GO:0010447 GO:0014070 GO:0021510 GO:0030166 GO:0030199 GO:0030246 GO:0030336 GO:0031012 GO:0043025 GO:0045202 GO:0060591 GO:0071363 GO:0072534 GO:0098966 GO:0098978 GO:0098982
GL_000110	Brevican core protein	P55068	Rattus norvegicus	10116	GABA-ergic synapse axon axon initial segment carbohydrate binding cell surface cell-matrix adhesion central nervous system development dendrite extracellular matrix extracellular space glial cell differentiation gliogenesis glutamatergic synapse hippocampus development hyaluronic acid binding neuron projection extension node of Ranvier perineuronal net perisynaptic extracellular matrix positive regulation of neuroblast proliferation regulation of neuronal synaptic plasticity side of membrane skeletal system development synapse synapse maturation synaptic membrane	GO:0001501 GO:0002052 GO:0005540 GO:0005615 GO:0007160 GO:0007417 GO:0009986 GO:0010001 GO:0021766 GO:0030246 GO:0030424 GO:0030425 GO:0031012 GO:0033268 GO:0042063 GO:0043194 GO:0045202 GO:0048168 GO:0060074 GO:0072534 GO:0097060 GO:0098552 GO:0098966 GO:0098978 GO:0098982 GO:1990138
GL_000111	Brevican core protein	Q61361	Mus musculus	10090	GABA-ergic synapse axon axon initial segment calcium ion binding carbohydrate binding cell surface cell-matrix adhesion central nervous system development dendrite extracellular matrix extracellular space glial cell differentiation glutamatergic synapse hippocampus development hyaluronic acid binding neuron projection extension node of Ranvier perineuronal net perisynaptic extracellular matrix positive regulation of neuroblast proliferation skeletal system development synapse synapse maturation synaptic membrane	GO:0001501 GO:0002052 GO:0005509 GO:0005540 GO:0005615 GO:0007160 GO:0007417 GO:0009986 GO:0010001 GO:0021766 GO:0030246 GO:0030424 GO:0030425 GO:0031012 GO:0033268 GO:0043194 GO:0045202 GO:0060074 GO:0072534 GO:0097060 GO:0098966 GO:0098978 GO:0098982 GO:1990138
GL_000878	Polycystin-1-like protein 2	Q7TN88	Mus musculus	10090	G-protein alpha-subunit binding calcium channel activity calcium ion binding carbohydrate binding detection of mechanical stimulus membrane	GO:0001965 GO:0005262 GO:0005509 GO:0016020 GO:0030246 GO:0050982
GL_000385	Ficolin-1	O70165	Mus musculus	10090	G protein-coupled receptor signaling pathway antigen binding carbohydrate binding carbohydrate derivative binding cell surface pattern recognition receptor signaling pathway collagen trimer collagen-containing extracellular matrix complement activation, lectin pathway extracellular space metal ion binding pattern recognition receptor activity plasma membrane positive regulation of interleukin-8 production signaling receptor binding	GO:0001867 GO:0002752 GO:0003823 GO:0005102 GO:0005581 GO:0005615 GO:0005886 GO:0007186 GO:0030246 GO:0032757 GO:0038187 GO:0046872 GO:0062023 GO:0097367
GL_000387	Ficolin-1	Q9WTS8	Rattus norvegicus	10116	G protein-coupled receptor signaling pathway antigen binding carbohydrate binding carbohydrate derivative binding cell surface pattern recognition receptor signaling pathway collagen trimer collagen-containing extracellular matrix complement activation, lectin pathway extracellular space metal ion binding pattern recognition receptor activity plasma membrane positive regulation of interleukin-8 production signaling receptor binding	GO:0001867 GO:0002752 GO:0003823 GO:0005102 GO:0005581 GO:0005615 GO:0005886 GO:0007186 GO:0030246 GO:0032757 GO:0038187 GO:0046872 GO:0062023 GO:0097367
GL_001665	Interleukin-2	P04351	Mus musculus	10090	G protein-coupled receptor signaling pathway T cell proliferation activated T cell proliferation adaptive immune response carbohydrate binding cytokine activity extracellular space extrinsic apoptotic signaling pathway in absence of ligand gene expression glycosphingolipid binding growth factor activity interleukin-2 receptor binding interleukin-2-mediated signaling pathway kappa-type opioid receptor binding leukocyte activation involved in immune response lymphocyte proliferation negative regulation of B cell apoptotic process negative regulation of T-helper 17 cell differentiation negative regulation of inflammatory response negative regulation of lymphocyte proliferation negative regulation of protein phosphorylation positive regulation of B cell proliferation positive regulation of T cell differentiation positive regulation of T cell proliferation positive regulation of activated T cell proliferation positive regulation of cytosolic calcium ion concentration positive regulation of dendritic spine development positive regulation of immunoglobulin production positive regulation of interleukin-17 production positive regulation of isotype switching to IgG isotypes positive regulation of plasma cell differentiation positive regulation of protein phosphorylation positive regulation of regulatory T cell differentiation positive regulation of transcription by RNA polymerase II positive regulation of type II interferon production positive regulation of tyrosine phosphorylation of STAT protein protein kinase C-activating G protein-coupled receptor signaling pathway regulation of CD4-positive, alpha-beta T cell proliferation regulation of T cell homeostatic proliferation response to ethanol transcription by RNA polymerase II	GO:0001933 GO:0001934 GO:0002250 GO:0002366 GO:0002639 GO:0002903 GO:0005125 GO:0005134 GO:0005615 GO:0006366 GO:0007186 GO:0007204 GO:0007205 GO:0008083 GO:0010467 GO:0030246 GO:0030890 GO:0031851 GO:0032729 GO:0032740 GO:0038110 GO:0042098 GO:0042102 GO:0042104 GO:0042531 GO:0043208 GO:0045471 GO:0045582 GO:0045591 GO:0045944 GO:0046013 GO:0046651 GO:0048304 GO:0050672 GO:0050728 GO:0050798 GO:0060999 GO:0097192 GO:1900100 GO:2000320 GO:2000561
GL_001667	Interleukin-2	P17108	Rattus norvegicus	10116	G protein-coupled receptor signaling pathway T cell proliferation activated T cell proliferation adaptive immune response carbohydrate binding cytokine activity extracellular space extrinsic apoptotic signaling pathway in absence of ligand gene expression glycosphingolipid binding growth factor activity interleukin-2 receptor binding interleukin-2-mediated signaling pathway kappa-type opioid receptor binding leukocyte activation involved in immune response lymphocyte proliferation negative regulation of B cell apoptotic process negative regulation of T-helper 17 cell differentiation negative regulation of inflammatory response negative regulation of lymphocyte proliferation negative regulation of protein phosphorylation positive regulation of B cell proliferation positive regulation of T cell differentiation positive regulation of T cell proliferation positive regulation of activated T cell proliferation positive regulation of cytosolic calcium ion concentration positive regulation of dendritic spine development positive regulation of immunoglobulin production positive regulation of interleukin-17 production positive regulation of isotype switching to IgG isotypes positive regulation of plasma cell differentiation positive regulation of protein phosphorylation positive regulation of regulatory T cell differentiation positive regulation of transcription by RNA polymerase II positive regulation of type II interferon production positive regulation of tyrosine phosphorylation of STAT protein protein kinase C-activating G protein-coupled receptor signaling pathway regulation of CD4-positive, alpha-beta T cell proliferation regulation of T cell homeostatic proliferation response to ethanol response to tacrolimus transcription by RNA polymerase II	GO:0001933 GO:0001934 GO:0002250 GO:0002366 GO:0002639 GO:0002903 GO:0005125 GO:0005134 GO:0005615 GO:0006366 GO:0007186 GO:0007204 GO:0007205 GO:0008083 GO:0010467 GO:0030246 GO:0030890 GO:0031851 GO:0032729 GO:0032740 GO:0038110 GO:0042098 GO:0042102 GO:0042104 GO:0042531 GO:0043208 GO:0045471 GO:0045582 GO:0045591 GO:0045944 GO:0046013 GO:0046651 GO:0048304 GO:0050672 GO:0050728 GO:0050798 GO:0060999 GO:0097192 GO:1900100 GO:1901327 GO:2000320 GO:2000561
GL_000074	Attractin-like protein 1	Q6A051	Mus musculus	10090	G protein-coupled receptor signaling pathway Notch binding carbohydrate binding plasma membrane	GO:0005112 GO:0005886 GO:0007186 GO:0030246
GL_000075	Attractin-like protein 1	Q5VV63	Homo sapiens	9606	G protein-coupled receptor signaling pathway Notch binding carbohydrate binding membrane	GO:0005112 GO:0007186 GO:0016020 GO:0030246