GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	UniProt ID	Species	Taxonomy ID	GO Labels	GO IDs ▼
GL_000052	Aggrecan core protein	P07897	Rattus norvegicus	10116	GABA-ergic synapse basement membrane calcium ion binding carbohydrate binding cartilage condensation cell adhesion cellular response to growth factor stimulus central nervous system development chondroblast differentiation chondrocyte development collagen fibril organization extracellular matrix extracellular space glial cell differentiation glutamatergic synapse heart development hyaluronic acid binding negative regulation of cell migration neuronal cell body ossification perineuronal net perisynaptic extracellular matrix positive regulation of neuroblast proliferation proteoglycan biosynthetic process response to acidic pH response to glucose response to gravity response to mechanical stimulus response to organic cyclic compound response to xenobiotic stimulus skeletal system development spinal cord development synapse	GO:0001501 GO:0001502 GO:0001503 GO:0002052 GO:0002063 GO:0005509 GO:0005540 GO:0005604 GO:0005615 GO:0007155 GO:0007417 GO:0007507 GO:0009410 GO:0009612 GO:0009629 GO:0009749 GO:0010001 GO:0010447 GO:0014070 GO:0021510 GO:0030166 GO:0030199 GO:0030246 GO:0030336 GO:0031012 GO:0043025 GO:0045202 GO:0060591 GO:0071363 GO:0072534 GO:0098966 GO:0098978 GO:0098982
GL_001852	Transcriptional regulator LsrR	P76141	Escherichia coli K-12	83333	DNA-templated transcription carbohydrate binding cis-regulatory region sequence-specific DNA binding cytosol identical protein binding regulation of DNA-templated transcription initiation response to heat	GO:0000987 GO:0005829 GO:0006351 GO:0009408 GO:0030246 GO:0042802 GO:2000142
GL_000990	Protein OS-9	Q13438	Homo sapiens	9606	Hrd1p ubiquitin ligase complex carbohydrate binding endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum unfolded protein response negative regulation of retrograde protein transport, ER to cytosol protease binding protein retention in ER lumen protein targeting protein ubiquitination response to endoplasmic reticulum stress retrograde protein transport, ER to cytosol ubiquitin-dependent ERAD pathway ubiquitin-dependent protein catabolic process	GO:0000836 GO:0002020 GO:0005783 GO:0005788 GO:0005789 GO:0006511 GO:0006605 GO:0006621 GO:0016567 GO:0030246 GO:0030433 GO:0030968 GO:0030970 GO:0034976 GO:1904153
GL_002059	Protein OS-9 homolog	Q99220	Saccharomyces cerevisiae S288C	559292	Hrd1p ubiquitin ligase ERAD-L complex Hrd1p ubiquitin ligase complex detection of unfolded protein endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum unfolded protein response identical protein binding luminal surveillance complex oligosaccharide binding retrograde protein transport, ER to cytosol ubiquitin-dependent ERAD pathway ubiquitin-dependent glycoprotein ERAD pathway	GO:0000836 GO:0000839 GO:0002235 GO:0005783 GO:0005788 GO:0005789 GO:0030433 GO:0030968 GO:0030970 GO:0034099 GO:0042802 GO:0070492 GO:0097466
GL_001835	Sorbitol dehydrogenase	Q00796	Homo sapiens	9606	(R,R)-butanediol dehydrogenase activity D-sorbitol dehydrogenase (acceptor) activity D-xylulose reductase activity L-iditol 2-dehydrogenase activity L-xylitol catabolic process L-xylitol metabolic process NAD binding carbohydrate binding cytosol extracellular exosome extracellular space flagellated sperm motility fructose biosynthetic process glucose metabolic process glucuronate catabolic process to xylulose 5-phosphate identical protein binding membrane mitochondrial membrane motile cilium ribitol 2-dehydrogenase activity sorbitol catabolic process zinc ion binding	GO:0000721 GO:0003939 GO:0005615 GO:0005829 GO:0006006 GO:0006062 GO:0008270 GO:0016020 GO:0019640 GO:0030246 GO:0030317 GO:0031514 GO:0031966 GO:0042802 GO:0046370 GO:0046526 GO:0047833 GO:0050255 GO:0051160 GO:0051164 GO:0051287 GO:0070062
GL_000558	Intermembrane lipid transfer protein Vps13D	Q9VU08	Drosophila melanogaster	7227	K63-linked polyubiquitin modification-dependent protein binding carbohydrate binding extrinsic component of membrane lipid transport lysosome mitochondrion organization mitophagy protein retention in Golgi apparatus protein targeting to vacuole ubiquitin binding	GO:0000423 GO:0005764 GO:0006623 GO:0006869 GO:0007005 GO:0019898 GO:0030246 GO:0043130 GO:0045053 GO:0070530
GL_001224	Alpha-mannosidase	P22855	Saccharomyces cerevisiae S288C	559292	Cvt complex alpha-mannosidase activity carbohydrate binding fungal-type vacuole membrane mannose catabolic process metal ion binding oligosaccharide catabolic process	GO:0000329 GO:0004559 GO:0009313 GO:0019309 GO:0030246 GO:0034270 GO:0046872
GL_001389	Cell wall acid trehalase ATC1	Q5AAU5	Candida albicans SC5314	237561	alpha,alpha-trehalase activity carbohydrate binding carbon utilization cell wall-bounded periplasmic space extracellular vesicle fungal-type cell wall fungal-type vacuole lumen membrane trehalose catabolic process	GO:0000328 GO:0004555 GO:0005993 GO:0009277 GO:0015976 GO:0016020 GO:0030246 GO:0030287 GO:1903561
GL_001739	Periplasmic/secreted acid trehalase ATH1	M1RNJ8	Nakaseomyces glabratus	5478	alpha,alpha-trehalase activity carbohydrate binding carbon utilization cell wall-bounded periplasmic space extracellular region fungal-type cell wall fungal-type vacuole lumen membrane periplasmic space trehalose catabolic process	GO:0000328 GO:0004555 GO:0005576 GO:0005993 GO:0009277 GO:0015976 GO:0016020 GO:0030246 GO:0030287 GO:0042597
GL_001225	Alpha-mannosidase	Q9UT61	Schizosaccharomyces pombe 972h-	284812	alpha-mannosidase activity carbohydrate binding cytosol fungal-type vacuole lumen fungal-type vacuole membrane mannose metabolic process mannosyl-oligosaccharide 1,3-alpha-mannosidase activity mannosyl-oligosaccharide 1,6-alpha-mannosidase activity metal ion binding oligosaccharide catabolic process	GO:0000328 GO:0000329 GO:0004559 GO:0005829 GO:0006013 GO:0009313 GO:0030246 GO:0046872 GO:0052767 GO:0052768