GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	UniProt ID	Species	Taxonomy ID ▲	GO Labels	GO IDs
GL_000969	Protein FAM3A	Q5R5C3	Pongo abelii	9601	carbohydrate binding extracellular region	GO:0005576 GO:0030246
GL_000250	Calnexin	Q5R440	Pongo abelii	9601	calcium ion binding carbohydrate binding clathrin-dependent endocytosis endoplasmic reticulum endoplasmic reticulum membrane melanosome presynapse protein folding synaptic vesicle endocytosis unfolded protein binding	GO:0005509 GO:0005783 GO:0005789 GO:0006457 GO:0030246 GO:0042470 GO:0048488 GO:0051082 GO:0072583 GO:0098793
GL_000797	N-acetylgalactosaminyltransferase 7	Q5RFJ6	Pongo abelii	9601	Golgi membrane carbohydrate binding metal ion binding polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation	GO:0000139 GO:0004653 GO:0006493 GO:0030246 GO:0046872
GL_001693	Lysosomal alpha-glucosidase	Q5R7A9	Pongo abelii	9601	alpha-1,4-glucosidase activity carbohydrate binding glycogen catabolic process lysosomal membrane maltose alpha-glucosidase activity	GO:0004558 GO:0005765 GO:0005980 GO:0030246 GO:0032450
GL_000987	Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1	Q5RCB9	Pongo abelii	9601	Golgi membrane O-glycan processing acetylglucosaminyltransferase activity carbohydrate binding manganese ion binding membrane protein O-linked glycosylation	GO:0000139 GO:0006493 GO:0008375 GO:0016020 GO:0016266 GO:0030145 GO:0030246
GL_000314	Chitinase-3-like protein 1	Q5RBP6	Pongo abelii	9601	activation of NF-kappaB-inducing kinase activity apoptotic process carbohydrate binding carbohydrate metabolic process cellular response to tumor necrosis factor chitin binding cytoplasm endoplasmic reticulum extracellular space inflammatory response lung development perinuclear region of cytoplasm positive regulation of ERK1 and ERK2 cascade positive regulation of angiogenesis positive regulation of interleukin-8 production positive regulation of peptidyl-threonine phosphorylation positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction response to interleukin-1 response to interleukin-6 response to mechanical stimulus response to tumor necrosis factor	GO:0005615 GO:0005737 GO:0005783 GO:0005975 GO:0006915 GO:0006954 GO:0007250 GO:0008061 GO:0009612 GO:0010800 GO:0030246 GO:0030324 GO:0032757 GO:0034612 GO:0045766 GO:0048471 GO:0051897 GO:0070374 GO:0070555 GO:0070741 GO:0071356
GL_000501	Galectin-4	P56470	Homo sapiens	9606	antibacterial peptide biosynthetic process carbohydrate binding cell adhesion collagen-containing extracellular matrix cytosol extracellular space galactoside binding plasma membrane	GO:0002780 GO:0005615 GO:0005829 GO:0005886 GO:0007155 GO:0016936 GO:0030246 GO:0062023
GL_000820	NKG2-C type II integral membrane protein	P26717	Homo sapiens	9606	MHC class I protein complex binding activating MHC class Ib receptor activity adaptive immune response carbohydrate binding cellular defense response external side of plasma membrane natural killer cell mediated immunity plasma membrane positive regulation of natural killer cell degranulation positive regulation of natural killer cell mediated cytotoxicity protein antigen binding receptor complex regulation of natural killer cell activation signal transduction stimulatory C-type lectin receptor signaling pathway transmembrane signaling receptor activity	GO:0002223 GO:0002228 GO:0002250 GO:0004888 GO:0005886 GO:0006968 GO:0007165 GO:0009897 GO:0023024 GO:0030246 GO:0032814 GO:0043235 GO:0043323 GO:0045954 GO:0062081 GO:1990405
GL_001829	Sclerostin	Q9BQB4	Homo sapiens	9606	BMP binding BMP signaling pathway DNA-binding transcription factor binding Golgi apparatus canonical Wnt signaling pathway carbohydrate binding cellular response to parathyroid hormone stimulus extracellular region extracellular space heparin binding localization molecular function inhibitor activity negative regulation of BMP signaling pathway negative regulation of Wnt signaling pathway negative regulation of canonical Wnt signaling pathway negative regulation of ossification negative regulation of protein-containing complex assembly ossification positive regulation of DNA-templated transcription protein-containing complex response to mechanical stimulus	GO:0001503 GO:0005576 GO:0005615 GO:0005794 GO:0008201 GO:0009612 GO:0030178 GO:0030246 GO:0030279 GO:0030509 GO:0030514 GO:0031333 GO:0032991 GO:0036122 GO:0045893 GO:0051179 GO:0060070 GO:0071374 GO:0090090 GO:0140297 GO:0140678
GL_001036	Putative C-type lectin-like domain family 1	Q8IZS7	Homo sapiens	9606	B cell adhesion carbohydrate binding plasma membrane positive regulation of T cell proliferation positive regulation of interleukin-4 production	GO:0005886 GO:0030246 GO:0032753 GO:0042102 GO:0097323