GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	UniProt ID	Species	Taxonomy ID ▼	GO Labels	GO IDs
GL_002355	Mannose-binding protein A	P19999	Rattus norvegicus	10116	calcium ion binding calcium-dependent carbohydrate binding calcium-dependent protein binding collagen trimer complement activation, classical pathway complement activation, lectin pathway defense response to Gram-positive bacterium extracellular space identical protein binding killing by host of symbiont cells mannose binding multivesicular body oligosaccharide binding phosphatidylinositol-4-phosphate binding polysaccharide binding positive regulation of phagocytosis protease binding protein homodimerization activity protein homotrimerization surfactant homeostasis	GO:0001867 GO:0002020 GO:0005509 GO:0005537 GO:0005581 GO:0005615 GO:0005771 GO:0006958 GO:0030247 GO:0042802 GO:0042803 GO:0043129 GO:0048306 GO:0050766 GO:0050830 GO:0051873 GO:0070207 GO:0070273 GO:0070492 GO:0120153
GL_002064	Regenerating islet-derived protein 3-beta	P25031	Rattus norvegicus	10116	acute-phase response antimicrobial humoral immune response mediated by antimicrobial peptide apical part of cell cellular response to L-arginine cellular response to tumor necrosis factor cellular response to xenobiotic stimulus defense response to Gram-negative bacterium defense response to Gram-positive bacterium estrous cycle extracellular space female pregnancy growth factor binding hormone activity identical protein binding metal ion binding midgut development negative regulation of apoptotic process negative regulation of cellular response to oxidative stress negative regulation of inflammatory response to wounding negative regulation of keratinocyte differentiation oligosaccharide binding peptidoglycan binding positive regulation of cell population proliferation positive regulation of protein phosphorylation protein-containing complex response to bacterium response to estradiol response to nutrient levels response to peptide hormone response to starvation response to wounding signaling receptor activity zymogen granule	GO:0001934 GO:0005179 GO:0005615 GO:0006953 GO:0007494 GO:0007565 GO:0008284 GO:0009611 GO:0009617 GO:0019838 GO:0031667 GO:0032355 GO:0032991 GO:0038023 GO:0042588 GO:0042594 GO:0042802 GO:0042834 GO:0043066 GO:0043434 GO:0044849 GO:0045177 GO:0045617 GO:0046872 GO:0050829 GO:0050830 GO:0061844 GO:0070492 GO:0071356 GO:0071466 GO:0106015 GO:1900408 GO:1903577
GL_000183	C-type lectin domain family 4 member F	P10716	Rattus norvegicus	10116	NK T cell activation carbohydrate binding endocytosis external side of plasma membrane galactose binding glycolipid binding plasma membrane positive regulation of gene expression	GO:0005534 GO:0005886 GO:0006897 GO:0009897 GO:0010628 GO:0030246 GO:0051132 GO:0051861
GL_000018	Adhesion G protein-coupled receptor L2	O88923	Rattus norvegicus	10116	G protein-coupled receptor activity PDZ domain binding adenylate cyclase-activating G protein-coupled receptor signaling pathway carbohydrate binding cell surface receptor signaling pathway glutamatergic synapse positive regulation of synapse assembly postsynaptic membrane response to bacterium synapse organization	GO:0004930 GO:0007166 GO:0007189 GO:0009617 GO:0030165 GO:0030246 GO:0045211 GO:0050808 GO:0051965 GO:0098978
GL_001824	Ribose-phosphate pyrophosphokinase 2	P09330	Rattus norvegicus	10116	5-phosphoribose 1-diphosphate biosynthetic process ADP binding AMP binding AMP biosynthetic process ATP binding GDP binding animal organ regeneration carbohydrate binding cytoplasm cytosol identical protein binding kinase activity magnesium ion binding pentose-phosphate shunt phosphorylation protein homodimerization activity protein-containing complex purine nucleotide biosynthetic process ribose phosphate diphosphokinase activity ribose phosphate diphosphokinase complex	GO:0000287 GO:0002189 GO:0004749 GO:0005524 GO:0005737 GO:0005829 GO:0006015 GO:0006098 GO:0006164 GO:0006167 GO:0016208 GO:0016301 GO:0016310 GO:0019003 GO:0030246 GO:0031100 GO:0032991 GO:0042802 GO:0042803 GO:0043531
GL_001499	Galactose mutarotase	Q66HG4	Rattus norvegicus	10116	aldose 1-epimerase activity carbohydrate binding carbohydrate metabolic process cytoplasm galactose catabolic process via UDP-galactose galactose metabolic process glucose metabolic process	GO:0004034 GO:0005737 GO:0005975 GO:0006006 GO:0006012 GO:0030246 GO:0033499
GL_001417	Contactin-2	P22063	Rattus norvegicus	10116	G protein-coupled adenosine receptor signaling pathway adult walking behavior axon axon guidance axon initial segment axonal fasciculation axonogenesis brain development carbohydrate binding cell surface cell-cell adhesion cell-cell adhesion mediator activity cell-matrix adhesion central nervous system myelination cerebral cortex GABAergic interneuron migration clustering of voltage-gated potassium channels establishment of localization in cell establishment of protein localization to juxtaparanode region of axon fat cell differentiation juxtaparanode region of axon learning microtubule cytoskeleton organization myelin sheath negative regulation of neuron differentiation neuron differentiation neuron migration neuron projection neuron projection development neuronal cell body node of Ranvier plasma membrane positive regulation of adenosine receptor signaling pathway positive regulation of protein processing postsynaptic membrane presynaptic membrane organization protein localization to juxtaparanode region of axon protein processing protein self-association receptor internalization reduction of food intake in response to dietary excess regulation of astrocyte differentiation regulation of axon diameter regulation of cell morphogenesis regulation of neuronal synaptic plasticity response to dietary excess side of membrane synapse	GO:0000226 GO:0001764 GO:0001973 GO:0002021 GO:0002023 GO:0005886 GO:0007160 GO:0007409 GO:0007411 GO:0007413 GO:0007420 GO:0007612 GO:0007628 GO:0009986 GO:0010954 GO:0016485 GO:0021853 GO:0022010 GO:0022604 GO:0030182 GO:0030246 GO:0030424 GO:0031133 GO:0031175 GO:0031623 GO:0033268 GO:0043005 GO:0043025 GO:0043194 GO:0043209 GO:0043621 GO:0044224 GO:0045163 GO:0045202 GO:0045211 GO:0045444 GO:0045665 GO:0048168 GO:0048710 GO:0051649 GO:0060168 GO:0071205 GO:0071206 GO:0097090 GO:0098552 GO:0098609 GO:0098632
GL_000809	Neurocan core protein	P55067	Rattus norvegicus	10116	GABA-ergic synapse calcium ion binding carbohydrate binding cell adhesion central nervous system development extracellular space glial cell differentiation glutamatergic synapse hyaluronic acid binding modulation of chemical synaptic transmission perineuronal net perisynaptic extracellular matrix plasma membrane positive regulation of neuroblast proliferation regulation of postsynapse organization regulation of synapse structural plasticity skeletal system development synapse	GO:0001501 GO:0002052 GO:0005509 GO:0005540 GO:0005615 GO:0005886 GO:0007155 GO:0007417 GO:0010001 GO:0030246 GO:0045202 GO:0050804 GO:0051823 GO:0072534 GO:0098966 GO:0098978 GO:0098982 GO:0099175
GL_002050	P-selectin	P98106	Rattus norvegicus	10116	calcium ion binding calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules calcium-dependent protein binding calcium-mediated signaling using intracellular calcium source cell-cell adhesion external side of plasma membrane extracellular space fucose binding heparin binding heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules inflammatory response leukocyte cell-cell adhesion leukocyte migration leukocyte tethering or rolling lipopolysaccharide binding membrane oligosaccharide binding plasma membrane platelet alpha granule membrane positive regulation of cell adhesion positive regulation of leukocyte migration positive regulation of leukocyte tethering or rolling positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of platelet activation regulation of cellular extravasation regulation of integrin activation response to cytokine response to lipopolysaccharide response to organic cyclic compound sialic acid binding	GO:0001530 GO:0002687 GO:0002691 GO:0005509 GO:0005615 GO:0005886 GO:0006954 GO:0007157 GO:0007159 GO:0008201 GO:0009897 GO:0010572 GO:0014070 GO:0016020 GO:0016339 GO:0031092 GO:0032496 GO:0033623 GO:0033691 GO:0034097 GO:0035584 GO:0042806 GO:0045785 GO:0048306 GO:0050900 GO:0050901 GO:0051897 GO:0070492 GO:0098609 GO:1903238
GL_000886	Polypeptide N-acetylgalactosaminyltransferase 1	Q10473	Rattus norvegicus	10116	Golgi apparatus Golgi cisterna membrane carbohydrate binding extracellular region manganese ion binding perinuclear region of cytoplasm polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation protein O-linked glycosylation via serine protein O-linked glycosylation via threonine	GO:0004653 GO:0005576 GO:0005794 GO:0006493 GO:0018242 GO:0018243 GO:0030145 GO:0030246 GO:0032580 GO:0048471