GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	UniProt ID	Monosaccharide Specificities	Species	Taxonomy ID ▲	GO Labels	GO IDs
GL_002042	Lithostathine-1-beta	P48304		Homo sapiens	9606	antimicrobial humoral immune response mediated by antimicrobial peptide extracellular exosome extracellular space oligosaccharide binding peptidoglycan binding positive regulation of cell population proliferation response to peptide hormone signaling receptor activity	GO:0005615 GO:0008284 GO:0038023 GO:0042834 GO:0043434 GO:0061844 GO:0070062 GO:0070492
GL_001992	C-type lectin domain family 18 member B	Q6UXF7		Homo sapiens	9606	Golgi apparatus endosome extracellular space polysaccharide binding sarcoplasmic reticulum	GO:0005615 GO:0005768 GO:0005794 GO:0016529 GO:0030247
GL_000137	C-type lectin domain family 1 member B	Q9P126		Homo sapiens	9606	carbohydrate binding cell surface cell surface receptor signaling pathway defense response plasma membrane platelet formation signal transduction transmembrane signaling receptor activity	GO:0004888 GO:0005886 GO:0006952 GO:0007165 GO:0007166 GO:0009986 GO:0030220 GO:0030246
GL_001741	Pleiotrophin	P21246		Homo sapiens	9606	Schaffer collateral - CA1 synapse bone mineralization carbohydrate binding chondroitin sulfate binding decidualization dendrite arborization dendrite regeneration endoplasmic reticulum estrous cycle extracellular region extracellular space growth factor activity heparin binding integrin binding integrin-mediated signaling pathway learning leukocyte chemotaxis involved in inflammatory response memory molecular function activator activity negative regulation of long-term synaptic potentiation negative regulation of neuroblast proliferation nervous system development oogenesis ossification involved in bone remodeling plasma membrane positive regulation of axon regeneration positive regulation of bone mineralization positive regulation of cell division positive regulation of cell population proliferation positive regulation of dendrite development positive regulation of hepatocyte proliferation positive regulation of leukocyte chemotaxis positive regulation of neuron projection development positive regulation of oligodendrocyte differentiation positive regulation of ossification positive regulation of stem cell differentiation protein kinase binding protein phosphatase inhibitor activity protein-containing complex receptor clustering regulation of endothelial cell migration regulation of hemopoiesis regulation of myelination regulation of stem cell population maintenance regulation of synaptic plasticity response to auditory stimulus tissue regeneration transmembrane receptor protein tyrosine phosphatase signaling pathway	GO:0002232 GO:0002690 GO:0004864 GO:0005178 GO:0005576 GO:0005615 GO:0005783 GO:0005886 GO:0007185 GO:0007229 GO:0007399 GO:0007406 GO:0007612 GO:0007613 GO:0008083 GO:0008201 GO:0008284 GO:0010594 GO:0010976 GO:0010996 GO:0019901 GO:0030246 GO:0030282 GO:0030501 GO:0031104 GO:0031641 GO:0032991 GO:0035374 GO:0042246 GO:0043113 GO:0043932 GO:0044849 GO:0045778 GO:0046697 GO:0048167 GO:0048477 GO:0048680 GO:0048714 GO:0051781 GO:0098685 GO:0140059 GO:0140677 GO:1900006 GO:1900272 GO:1903706 GO:2000036 GO:2000347 GO:2000738
GL_000143	C-type lectin domain family 12 member A	Q5QGZ9		Homo sapiens	9606	carbohydrate binding plasma membrane signal transduction signaling receptor regulator activity specific granule membrane tertiary granule membrane transmembrane signaling receptor activity	GO:0004888 GO:0005886 GO:0007165 GO:0030246 GO:0030545 GO:0035579 GO:0070821
GL_001648	Hematopoietic progenitor cell antigen CD34	P28906		Homo sapiens	9606	RNA polymerase II-specific DNA-binding transcription factor binding apical plasma membrane basal plasma membrane carbohydrate binding cell motility cell-cell adhesion cell-matrix adhesion cytoplasm endothelial cell proliferation endothelium development external side of plasma membrane extracellular exosome assembly extracellular region glomerular endothelium development glomerular endothelium fenestra glomerular filtration hematopoietic stem cell proliferation hemopoiesis intercellular bridge leukocyte migration lysosome mesangial cell-matrix adhesion metanephric glomerular mesangial cell differentiation negative regulation of gene expression negative regulation of interleukin-2 production paracrine signaling perinuclear region of cytoplasm plasma membrane positive regulation of angiogenesis positive regulation of gene expression positive regulation of granulocyte colony-stimulating factor production positive regulation of odontogenesis positive regulation of vasculogenesis signal transduction stem cell proliferation sulfate binding tissue homeostasis transdifferentiation vascular wound healing	GO:0001894 GO:0001935 GO:0003094 GO:0003158 GO:0005576 GO:0005737 GO:0005764 GO:0005886 GO:0007160 GO:0007165 GO:0009897 GO:0009925 GO:0010628 GO:0010629 GO:0016324 GO:0030097 GO:0030246 GO:0032703 GO:0035759 GO:0036053 GO:0038001 GO:0042482 GO:0043199 GO:0045171 GO:0045766 GO:0048471 GO:0048870 GO:0050900 GO:0060290 GO:0061042 GO:0061629 GO:0071425 GO:0071657 GO:0071971 GO:0072011 GO:0072089 GO:0072254 GO:0098609 GO:2001214
GL_001376	BOS complex subunit NOMO1	Q15155		Homo sapiens	9606	carbohydrate binding endoplasmic reticulum membrane membrane multi-pass translocon complex multi-pass transmembrane protein insertion into ER membrane ribosome binding	GO:0005789 GO:0016020 GO:0030246 GO:0043022 GO:0160063 GO:0160064
GL_000109	Brevican core protein	Q96GW7		Homo sapiens	9606	Golgi lumen carbohydrate binding cell adhesion central nervous system development extracellular region extracellular space glial cell differentiation glutamatergic synapse hippocampus development hyaluronic acid binding lysosomal lumen perineuronal net positive regulation of neuroblast proliferation side of membrane skeletal system development synapse synapse maturation	GO:0001501 GO:0002052 GO:0005540 GO:0005576 GO:0005615 GO:0005796 GO:0007155 GO:0007417 GO:0010001 GO:0021766 GO:0030246 GO:0043202 GO:0045202 GO:0060074 GO:0072534 GO:0098552 GO:0098978
GL_000491	Galectin-3	P17931	Gal	Homo sapiens	9606	IgE binding RNA binding RNA splicing carbohydrate binding cell surface chemoattractant activity collagen-containing extracellular matrix cytoplasm cytosol eosinophil chemotaxis epithelial cell differentiation extracellular exosome extracellular region extracellular space ficolin-1-rich granule membrane immunological synapse innate immune response laminin binding mRNA processing macrophage chemotaxis membrane mitochondrial inner membrane molecular condensate scaffold activity monocyte chemotaxis mononuclear cell migration negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell negative regulation of T cell receptor signaling pathway negative regulation of endocytosis negative regulation of extrinsic apoptotic signaling pathway negative regulation of immunological synapse formation negative regulation of protein tyrosine phosphatase activity neutrophil chemotaxis nucleoplasm nucleus plasma membrane positive chemotaxis positive regulation of calcium ion import positive regulation of mononuclear cell migration positive regulation of protein localization to plasma membrane positive regulation of protein-containing complex assembly protein phosphatase binding protein phosphatase inhibitor activity regulation of T cell apoptotic process regulation of T cell proliferation regulation of extrinsic apoptotic signaling pathway via death domain receptors secretory granule membrane spliceosomal complex	GO:0001772 GO:0002548 GO:0003723 GO:0004864 GO:0005576 GO:0005615 GO:0005634 GO:0005654 GO:0005681 GO:0005737 GO:0005743 GO:0005829 GO:0005886 GO:0006397 GO:0008380 GO:0009986 GO:0016020 GO:0019863 GO:0019903 GO:0030246 GO:0030593 GO:0030667 GO:0030855 GO:0031334 GO:0042056 GO:0042129 GO:0043236 GO:0045087 GO:0045806 GO:0048245 GO:0048246 GO:0050860 GO:0050918 GO:0062023 GO:0070062 GO:0070232 GO:0071674 GO:0071677 GO:0090280 GO:0101003 GO:0140693 GO:1902041 GO:1903078 GO:1903614 GO:2000521 GO:2001189 GO:2001237
GL_000507	Galectin-7	P47929	Gal	Homo sapiens	9606	apoptotic process carbohydrate binding cytoplasm extracellular exosome extracellular space heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules nucleus	GO:0005615 GO:0005634 GO:0005737 GO:0006915 GO:0007157 GO:0030246 GO:0070062