GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin ▼	Lectin Name	UniProt ID	Species	Taxonomy ID	GO Labels	GO IDs
GL_000273	Calreticulin	Q23858	Dictyostelium discoideum	44689	calcium ion binding carbohydrate binding endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane phagocytic vesicle phagocytosis, engulfment protein folding response to other organism ubiquitin-dependent ERAD pathway unfolded protein binding	GO:0005509 GO:0005783 GO:0005788 GO:0005789 GO:0006457 GO:0006911 GO:0030246 GO:0030433 GO:0045335 GO:0051082 GO:0051707
GL_000272	Calreticulin	P27797	Homo sapiens	9606	DNA binding MHC class I peptide loading complex RNA binding acrosomal vesicle calcium ion binding carbohydrate binding cardiac muscle cell differentiation cell surface cellular response to electrical stimulus cellular response to lithium ion cellular response to virus cellular senescence collagen-containing extracellular matrix complement component C1q complex binding cortical actin cytoskeleton organization cortical granule cytolytic granule cytoplasm cytosol endocytic vesicle lumen endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum quality control compartment endoplasmic reticulum-Golgi intermediate compartment membrane external side of plasma membrane extracellular exosome extracellular region extracellular space focal adhesion glucocorticoid receptor signaling pathway hormone binding integrin binding intracellular calcium ion homeostasis iron ion binding lumenal side of endoplasmic reticulum membrane mRNA binding membrane negative regulation of DNA-templated transcription negative regulation of intracellular steroid hormone receptor signaling pathway negative regulation of neuron differentiation negative regulation of retinoic acid receptor signaling pathway negative regulation of transcription by RNA polymerase II negative regulation of translation negative regulation of trophoblast cell migration nuclear androgen receptor binding nuclear envelope nuclear export signal receptor activity nucleus obsolete selective autophagy peptide antigen assembly with MHC class I protein complex peptide binding perinuclear region of cytoplasm phagocytic vesicle membrane polysome positive regulation of cell cycle positive regulation of cell population proliferation positive regulation of dendritic cell chemotaxis positive regulation of endothelial cell migration positive regulation of gene expression positive regulation of non-canonical NF-kappaB signal transduction positive regulation of phagocytosis positive regulation of substrate adhesion-dependent cell spreading protein export from nucleus protein folding protein folding chaperone protein folding in endoplasmic reticulum protein localization to nucleus protein maturation by protein folding protein stabilization protein-folding chaperone binding regulation of DNA-templated transcription regulation of apoptotic process regulation of meiotic nuclear division response to estradiol response to glycoside response to testosterone response to xenobiotic stimulus sarcoplasmic reticulum lumen sequestering of calcium ion smooth endoplasmic reticulum spermatogenesis ubiquitin protein ligase binding ubiquitin-dependent ERAD pathway unfolded protein binding zinc ion binding	GO:0000122 GO:0001669 GO:0001849 GO:0002502 GO:0003677 GO:0003723 GO:0003729 GO:0005049 GO:0005178 GO:0005506 GO:0005509 GO:0005576 GO:0005615 GO:0005634 GO:0005635 GO:0005737 GO:0005783 GO:0005788 GO:0005789 GO:0005790 GO:0005829 GO:0005844 GO:0005925 GO:0006355 GO:0006457 GO:0006611 GO:0006874 GO:0007283 GO:0008270 GO:0008284 GO:0009410 GO:0009897 GO:0009986 GO:0010595 GO:0010628 GO:0016020 GO:0017148 GO:0022417 GO:0030246 GO:0030433 GO:0030670 GO:0030866 GO:0031625 GO:0032355 GO:0033018 GO:0033116 GO:0033144 GO:0033574 GO:0034504 GO:0034975 GO:0040020 GO:0042277 GO:0042562 GO:0042824 GO:0042921 GO:0042981 GO:0044183 GO:0044194 GO:0044322 GO:0045665 GO:0045787 GO:0045892 GO:0048387 GO:0048471 GO:0050681 GO:0050766 GO:0050821 GO:0051082 GO:0051087 GO:0051208 GO:0055007 GO:0060473 GO:0061912 GO:0062023 GO:0070062 GO:0071257 GO:0071285 GO:0071682 GO:0090398 GO:0098553 GO:0098586 GO:1900026 GO:1901164 GO:1901224 GO:1903416 GO:2000510
GL_000271	Calreticulin	P14211	Mus musculus	10090	MHC class I peptide loading complex acrosomal vesicle calcium ion binding carbohydrate binding cardiac muscle cell differentiation cell surface cellular response to electrical stimulus cellular response to lithium ion cellular response to organic substance cellular response to virus cellular senescence collagen-containing extracellular matrix complement component C1q complex binding cortical actin cytoskeleton organization cortical granule cytolytic granule cytoplasm cytosol endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum quality control compartment external side of plasma membrane extracellular region extracellular space hormone binding integrin binding iron ion binding mRNA binding membrane negative regulation of DNA-templated transcription negative regulation of intracellular steroid hormone receptor signaling pathway negative regulation of neuron differentiation negative regulation of retinoic acid receptor signaling pathway negative regulation of transcription by RNA polymerase II negative regulation of translation negative regulation of trophoblast cell migration nuclear androgen receptor binding nuclear envelope nuclear export signal receptor activity nucleus obsolete selective autophagy peptide antigen assembly with MHC class I protein complex peptide binding perinuclear region of cytoplasm phagocytic vesicle polysome positive regulation of cell cycle positive regulation of cell population proliferation positive regulation of dendritic cell chemotaxis positive regulation of endothelial cell migration positive regulation of gene expression positive regulation of non-canonical NF-kappaB signal transduction positive regulation of phagocytosis positive regulation of substrate adhesion-dependent cell spreading protein export from nucleus protein folding protein localization to nucleus protein stabilization protein-containing complex regulation of meiotic nuclear division response to estradiol response to glycoside response to testosterone response to xenobiotic stimulus sarcoplasmic reticulum sarcoplasmic reticulum lumen smooth endoplasmic reticulum spermatogenesis ubiquitin protein ligase binding ubiquitin-dependent ERAD pathway unfolded protein binding	GO:0000122 GO:0001669 GO:0001849 GO:0002502 GO:0003729 GO:0005049 GO:0005178 GO:0005506 GO:0005509 GO:0005576 GO:0005615 GO:0005634 GO:0005635 GO:0005737 GO:0005783 GO:0005788 GO:0005789 GO:0005790 GO:0005829 GO:0005844 GO:0006457 GO:0006611 GO:0007283 GO:0008284 GO:0009410 GO:0009897 GO:0009986 GO:0010595 GO:0010628 GO:0016020 GO:0016529 GO:0017148 GO:0030246 GO:0030433 GO:0030866 GO:0031625 GO:0032355 GO:0032991 GO:0033018 GO:0033144 GO:0033574 GO:0034504 GO:0040020 GO:0042277 GO:0042562 GO:0042824 GO:0044194 GO:0044322 GO:0045335 GO:0045665 GO:0045787 GO:0045892 GO:0048387 GO:0048471 GO:0050681 GO:0050766 GO:0050821 GO:0051082 GO:0055007 GO:0060473 GO:0061912 GO:0062023 GO:0071257 GO:0071285 GO:0071310 GO:0090398 GO:0098586 GO:1900026 GO:1901164 GO:1901224 GO:1903416 GO:2000510
GL_000270	Calreticulin	P52193	Bos taurus	9913	calcium ion binding carbohydrate binding cell surface cortical granule cytolytic granule cytosol endoplasmic reticulum membrane extracellular region protein folding protein stabilization sarcoplasmic reticulum lumen ubiquitin-dependent ERAD pathway unfolded protein binding	GO:0005509 GO:0005576 GO:0005789 GO:0005829 GO:0006457 GO:0009986 GO:0030246 GO:0030433 GO:0033018 GO:0044194 GO:0050821 GO:0051082 GO:0060473
GL_000269	Calreticulin	P18418	Rattus norvegicus	10116	MHC class I peptide loading complex acrosomal vesicle calcium ion binding carbohydrate binding cardiac muscle cell differentiation cell surface cellular response to electrical stimulus cellular response to lithium ion cellular response to organic substance cellular response to virus cellular senescence collagen-containing extracellular matrix complement component C1q complex binding cortical actin cytoskeleton organization cortical granule cytolytic granule cytoplasm cytosol endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum quality control compartment external side of plasma membrane extracellular space hormone binding integrin binding iron ion binding mRNA binding membrane negative regulation of DNA-templated transcription negative regulation of intracellular steroid hormone receptor signaling pathway negative regulation of neuron differentiation negative regulation of retinoic acid receptor signaling pathway negative regulation of transcription by RNA polymerase II negative regulation of translation negative regulation of trophoblast cell migration nuclear androgen receptor binding nuclear envelope nuclear export signal receptor activity nucleus obsolete selective autophagy peptide antigen assembly with MHC class I protein complex peptide binding perinuclear region of cytoplasm polysome positive regulation of cell cycle positive regulation of cell population proliferation positive regulation of dendritic cell chemotaxis positive regulation of endothelial cell migration positive regulation of gene expression positive regulation of non-canonical NF-kappaB signal transduction positive regulation of phagocytosis positive regulation of substrate adhesion-dependent cell spreading protein export from nucleus protein folding protein localization to nucleus protein stabilization protein-containing complex regulation of meiotic nuclear division response to estradiol response to glycoside response to organic substance response to testosterone response to xenobiotic stimulus sarcoplasmic reticulum sarcoplasmic reticulum lumen smooth endoplasmic reticulum spermatogenesis ubiquitin protein ligase binding ubiquitin-dependent ERAD pathway unfolded protein binding	GO:0000122 GO:0001669 GO:0001849 GO:0002502 GO:0003729 GO:0005049 GO:0005178 GO:0005506 GO:0005509 GO:0005615 GO:0005634 GO:0005635 GO:0005737 GO:0005783 GO:0005788 GO:0005789 GO:0005790 GO:0005829 GO:0005844 GO:0006457 GO:0006611 GO:0007283 GO:0008284 GO:0009410 GO:0009897 GO:0009986 GO:0010033 GO:0010595 GO:0010628 GO:0016020 GO:0016529 GO:0017148 GO:0030246 GO:0030433 GO:0030866 GO:0031625 GO:0032355 GO:0032991 GO:0033018 GO:0033144 GO:0033574 GO:0034504 GO:0040020 GO:0042277 GO:0042562 GO:0042824 GO:0044194 GO:0044322 GO:0045665 GO:0045787 GO:0045892 GO:0048387 GO:0048471 GO:0050681 GO:0050766 GO:0050821 GO:0051082 GO:0055007 GO:0060473 GO:0061912 GO:0062023 GO:0071257 GO:0071285 GO:0071310 GO:0090398 GO:0098586 GO:1900026 GO:1901164 GO:1901224 GO:1903416 GO:2000510
GL_000268	Calreticulin	Q9SLY8	Oryza sativa Japonica Group	39947	calcium ion binding carbohydrate binding endoplasmic reticulum lumen endoplasmic reticulum membrane protein folding ubiquitin-dependent ERAD pathway unfolded protein binding	GO:0005509 GO:0005788 GO:0005789 GO:0006457 GO:0030246 GO:0030433 GO:0051082
GL_000267	Calreticulin	Q06814	Schistosoma mansoni	6183	calcium ion binding carbohydrate binding endoplasmic reticulum lumen protein folding unfolded protein binding	GO:0005509 GO:0005788 GO:0006457 GO:0030246 GO:0051082
GL_000266	Calreticulin	P83003	Entamoeba histolytica HM-1:IMSS	294381	calcium ion binding carbohydrate binding cell surface complement component C1q complex binding cytosol endoplasmic reticulum endoplasmic reticulum lumen evasion of host immune response via modulation of host complement system host cell surface binding phagocytic cup positive regulation of phagocytosis protein export from nucleus protein folding unfolded protein binding uropod	GO:0001849 GO:0001891 GO:0001931 GO:0005509 GO:0005783 GO:0005788 GO:0005829 GO:0006457 GO:0006611 GO:0009986 GO:0030246 GO:0042784 GO:0046812 GO:0050766 GO:0051082
GL_000265	Calreticulin	Q61KR9	Caenorhabditis briggsae	6238	calcium ion binding carbohydrate binding defecation endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum unfolded protein response hemidesmosome assembly multicellular organismal reproductive process programmed cell death protein folding regulation of gene expression response to ethanol response to heat ubiquitin-dependent ERAD pathway unfolded protein binding	GO:0005509 GO:0005788 GO:0005789 GO:0006457 GO:0009408 GO:0010468 GO:0012501 GO:0030246 GO:0030421 GO:0030433 GO:0030968 GO:0031581 GO:0045471 GO:0048609 GO:0051082
GL_000264	Calreticulin	P29413	Drosophila melanogaster	7227	calcium ion binding carbohydrate binding endomembrane system endoplasmic reticulum lumen endoplasmic reticulum membrane extracellular space fusome olfactory behavior protein folding sleep ubiquitin-dependent ERAD pathway unfolded protein binding	GO:0005509 GO:0005615 GO:0005788 GO:0005789 GO:0006457 GO:0012505 GO:0030246 GO:0030431 GO:0030433 GO:0042048 GO:0045169 GO:0051082