GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	UniProt ID	Species	Taxonomy ID ▼	GO Labels	GO IDs
GL_000108	Bone marrow proteoglycan	Q63189	Rattus norvegicus	10116	carbohydrate binding defense response to bacterium defense response to nematode extracellular region heparin binding immune response negative regulation of interleukin-10 production negative regulation of macrophage cytokine production positive regulation of interleukin-4 production	GO:0002215 GO:0005576 GO:0006955 GO:0008201 GO:0010936 GO:0030246 GO:0032693 GO:0032753 GO:0042742
GL_001671	Keratin, type II cytoskeletal 1	Q6IMF3	Rattus norvegicus	10116	carbohydrate binding complement activation, lectin pathway cornified envelope cytoplasm establishment of skin barrier intermediate filament organization keratin filament keratinization membrane negative regulation of inflammatory response protein heterodimerization activity protein heterotetramerization structural constituent of skin epidermis	GO:0001533 GO:0001867 GO:0005737 GO:0016020 GO:0030246 GO:0030280 GO:0031424 GO:0045095 GO:0045109 GO:0046982 GO:0050728 GO:0051290 GO:0061436
GL_000269	Calreticulin	P18418	Rattus norvegicus	10116	MHC class I peptide loading complex acrosomal vesicle calcium ion binding carbohydrate binding cardiac muscle cell differentiation cell surface cellular response to electrical stimulus cellular response to lithium ion cellular response to organic substance cellular response to virus cellular senescence collagen-containing extracellular matrix complement component C1q complex binding cortical actin cytoskeleton organization cortical granule cytolytic granule cytoplasm cytosol endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum quality control compartment external side of plasma membrane extracellular space hormone binding integrin binding iron ion binding mRNA binding membrane negative regulation of DNA-templated transcription negative regulation of intracellular steroid hormone receptor signaling pathway negative regulation of neuron differentiation negative regulation of retinoic acid receptor signaling pathway negative regulation of transcription by RNA polymerase II negative regulation of translation negative regulation of trophoblast cell migration nuclear androgen receptor binding nuclear envelope nuclear export signal receptor activity nucleus obsolete selective autophagy peptide antigen assembly with MHC class I protein complex peptide binding perinuclear region of cytoplasm polysome positive regulation of cell cycle positive regulation of cell population proliferation positive regulation of dendritic cell chemotaxis positive regulation of endothelial cell migration positive regulation of gene expression positive regulation of non-canonical NF-kappaB signal transduction positive regulation of phagocytosis positive regulation of substrate adhesion-dependent cell spreading protein export from nucleus protein folding protein localization to nucleus protein stabilization protein-containing complex regulation of meiotic nuclear division response to estradiol response to glycoside response to organic substance response to testosterone response to xenobiotic stimulus sarcoplasmic reticulum sarcoplasmic reticulum lumen smooth endoplasmic reticulum spermatogenesis ubiquitin protein ligase binding ubiquitin-dependent ERAD pathway unfolded protein binding	GO:0000122 GO:0001669 GO:0001849 GO:0002502 GO:0003729 GO:0005049 GO:0005178 GO:0005506 GO:0005509 GO:0005615 GO:0005634 GO:0005635 GO:0005737 GO:0005783 GO:0005788 GO:0005789 GO:0005790 GO:0005829 GO:0005844 GO:0006457 GO:0006611 GO:0007283 GO:0008284 GO:0009410 GO:0009897 GO:0009986 GO:0010033 GO:0010595 GO:0010628 GO:0016020 GO:0016529 GO:0017148 GO:0030246 GO:0030433 GO:0030866 GO:0031625 GO:0032355 GO:0032991 GO:0033018 GO:0033144 GO:0033574 GO:0034504 GO:0040020 GO:0042277 GO:0042562 GO:0042824 GO:0044194 GO:0044322 GO:0045665 GO:0045787 GO:0045892 GO:0048387 GO:0048471 GO:0050681 GO:0050766 GO:0050821 GO:0051082 GO:0055007 GO:0060473 GO:0061912 GO:0062023 GO:0071257 GO:0071285 GO:0071310 GO:0090398 GO:0098586 GO:1900026 GO:1901164 GO:1901224 GO:1903416 GO:2000510
GL_001192	6-phosphogluconate dehydrogenase, decarboxylating	P85968	Rattus norvegicus	10116	D-gluconate catabolic process D-gluconate metabolic process NADP binding NADP metabolic process carbohydrate binding carboxylic acid binding cytosol pentose biosynthetic process pentose-phosphate shunt pentose-phosphate shunt, oxidative branch phosphogluconate dehydrogenase (decarboxylating) activity	GO:0004616 GO:0005829 GO:0006098 GO:0006739 GO:0009051 GO:0019322 GO:0019521 GO:0030246 GO:0031406 GO:0046177 GO:0050661
GL_000142	C-type lectin domain family 11 member A	O88201	Rattus norvegicus	10116	carbohydrate binding cytoplasm extracellular region extracellular space growth factor activity ossification positive regulation of cell population proliferation	GO:0001503 GO:0005576 GO:0005615 GO:0005737 GO:0008083 GO:0008284 GO:0030246
GL_000495	Galectin-3	P08699	Rattus norvegicus	10116	Fc-gamma receptor I complex binding IgE binding RNA splicing advanced glycation end-product receptor activity carbohydrate binding cell surface chemoattractant activity cornified envelope cytoplasm disaccharide binding eosinophil chemotaxis epithelial cell differentiation external side of plasma membrane extracellular matrix extracellular matrix organization extracellular space glial cell projection immunological synapse innate immune response laminin binding mRNA processing macrophage chemotaxis mitochondrial inner membrane molecular condensate scaffold activity monocyte chemotaxis mononuclear cell migration monosaccharide binding negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell negative regulation of T cell receptor signaling pathway negative regulation of apoptotic process negative regulation of cell proliferation in bone marrow negative regulation of endocytosis negative regulation of extrinsic apoptotic signaling pathway negative regulation of immunological synapse formation neutrophil chemotaxis nucleus plasma membrane positive chemotaxis positive regulation of angiogenesis positive regulation of calcium ion import positive regulation of cell population proliferation positive regulation of mononuclear cell migration positive regulation of protein localization to plasma membrane positive regulation of protein-containing complex assembly positive regulation of serotonin secretion protein phosphatase binding regulation of T cell apoptotic process regulation of T cell proliferation regulation of extrinsic apoptotic signaling pathway via death domain receptors response to quercetin skeletal system development spliceosomal complex	GO:0001501 GO:0001533 GO:0001772 GO:0002548 GO:0005615 GO:0005634 GO:0005681 GO:0005737 GO:0005743 GO:0005886 GO:0006397 GO:0008284 GO:0008380 GO:0009897 GO:0009986 GO:0014064 GO:0019863 GO:0019903 GO:0030198 GO:0030246 GO:0030593 GO:0030855 GO:0031012 GO:0031334 GO:0034988 GO:0042056 GO:0042129 GO:0043066 GO:0043236 GO:0045087 GO:0045766 GO:0045806 GO:0048029 GO:0048030 GO:0048245 GO:0048246 GO:0050785 GO:0050860 GO:0050918 GO:0070232 GO:0071674 GO:0071677 GO:0090280 GO:0097386 GO:0140693 GO:1902041 GO:1903078 GO:1903769 GO:1905235 GO:2000521 GO:2001189 GO:2001237
GL_000504	Galectin-5	P47967	Rattus norvegicus	10116	carbohydrate binding cytosol galactoside binding lactose binding negative regulation of CD4-positive, alpha-beta T cell proliferation negative regulation of type II interferon production nucleus positive regulation of T cell apoptotic process positive regulation of gene expression	GO:0005634 GO:0005829 GO:0010628 GO:0016936 GO:0030246 GO:0030395 GO:0032689 GO:0070234 GO:2000562
GL_000302	CD302 antigen	Q5FVR3	Rattus norvegicus	10116	carbohydrate binding cell cortex external side of plasma membrane filopodium microvillus phagocytosis signaling receptor activity	GO:0005902 GO:0005938 GO:0006909 GO:0009897 GO:0030175 GO:0030246 GO:0038023
GL_000157	C-type lectin domain family 2 member D2	A4KWA5	Rattus norvegicus	10116	carbohydrate binding external side of plasma membrane natural killer cell lectin-like receptor binding	GO:0009897 GO:0030246 GO:0046703
GL_001204	Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Q09326	Rattus norvegicus	10116	Golgi membrane Golgi stack alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity carbohydrate binding manganese ion binding oligosaccharide biosynthetic process protein N-linked glycosylation protein N-linked glycosylation via asparagine protein homodimerization activity	GO:0000139 GO:0005795 GO:0006487 GO:0008455 GO:0009312 GO:0018279 GO:0030145 GO:0030246 GO:0042803