GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	UniProt ID	Species	Taxonomy ID ▼	GO Labels	GO IDs
GL_000985	Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1	Q8WZA1	Homo sapiens	9606	Golgi membrane O-glycan processing acetylglucosaminyltransferase activity basement membrane organization beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity carbohydrate binding dentate gyrus development gene expression localization of cell manganese ion binding membrane myelination protein O-linked glycosylation protein O-linked mannosylation reactive gliosis sensory perception of sound	GO:0000139 GO:0006493 GO:0007605 GO:0008375 GO:0010467 GO:0016020 GO:0016266 GO:0021542 GO:0030145 GO:0030246 GO:0035269 GO:0042552 GO:0047223 GO:0051674 GO:0071711 GO:0150103
GL_000823	NKG2-D type II integral membrane protein	P26718	Homo sapiens	9606	MHC class I protein binding MHC class Ib receptor activity T cell costimulation adaptive immune response carbohydrate binding cell differentiation cell surface cellular response to lipopolysaccharide defense response to Gram-positive bacterium external side of plasma membrane identical protein binding membrane natural killer cell activation natural killer cell mediated cytotoxicity negative regulation of GTPase activity negative regulation of natural killer cell chemotaxis nitric oxide biosynthetic process plasma membrane positive regulation of natural killer cell mediated cytotoxicity positive regulation of nitric oxide biosynthetic process positive regulation of type II interferon production signal transduction signaling receptor activity stimulatory C-type lectin receptor signaling pathway	GO:0002223 GO:0002250 GO:0005886 GO:0006809 GO:0007165 GO:0009897 GO:0009986 GO:0016020 GO:0030101 GO:0030154 GO:0030246 GO:0031295 GO:0032394 GO:0032729 GO:0034260 GO:0038023 GO:0042267 GO:0042288 GO:0042802 GO:0045429 GO:0045954 GO:0050830 GO:0071222 GO:2000502
GL_002017	Galectin-12	Q96DT0	Homo sapiens	9606	cytoplasm intrinsic apoptotic signaling pathway lactose binding mitochondrion nucleus	GO:0005634 GO:0005737 GO:0005739 GO:0030395 GO:0097193
GL_000239	C-type mannose receptor 2	Q9UBG0	Homo sapiens	9606	carbohydrate binding collagen binding collagen catabolic process endocytosis focal adhesion membrane osteoblast differentiation signaling receptor activity	GO:0001649 GO:0005518 GO:0005925 GO:0006897 GO:0016020 GO:0030246 GO:0030574 GO:0038023
GL_000249	Calnexin	P27824	Homo sapiens	9606	RNA binding calcium ion binding carbohydrate binding clathrin-dependent endocytosis endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum quality control compartment extracellular exosome lumenal side of endoplasmic reticulum membrane melanosome membrane mitochondria-associated endoplasmic reticulum membrane nuclear membrane presynapse protein folding protein folding in endoplasmic reticulum protein secretion synaptic vesicle endocytosis ubiquitin-dependent ERAD pathway unfolded protein binding viral protein processing	GO:0003723 GO:0005509 GO:0005783 GO:0005788 GO:0005789 GO:0006457 GO:0009306 GO:0016020 GO:0019082 GO:0030246 GO:0030433 GO:0031965 GO:0034975 GO:0042470 GO:0044233 GO:0044322 GO:0048488 GO:0051082 GO:0070062 GO:0072583 GO:0098553 GO:0098793
GL_000990	Protein OS-9	Q13438	Homo sapiens	9606	Hrd1p ubiquitin ligase complex carbohydrate binding endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum unfolded protein response negative regulation of retrograde protein transport, ER to cytosol protease binding protein retention in ER lumen protein targeting protein ubiquitination response to endoplasmic reticulum stress retrograde protein transport, ER to cytosol ubiquitin-dependent ERAD pathway ubiquitin-dependent protein catabolic process	GO:0000836 GO:0002020 GO:0005783 GO:0005788 GO:0005789 GO:0006511 GO:0006605 GO:0006621 GO:0016567 GO:0030246 GO:0030433 GO:0030968 GO:0030970 GO:0034976 GO:1904153
GL_001238	Alpha-mannosidase 2x	P49641	Homo sapiens	9606	Golgi membrane N-glycan processing alpha-mannosidase activity carbohydrate binding hydrolase activity, hydrolyzing N-glycosyl compounds mannose metabolic process mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity metal ion binding protein glycosylation	GO:0000139 GO:0004559 GO:0004572 GO:0006013 GO:0006486 GO:0006491 GO:0016799 GO:0030246 GO:0046872
GL_000842	Pancreatic adenocarcinoma up-regulated factor	Q96DA0	Homo sapiens	9606	carbohydrate binding extracellular exosome extracellular space	GO:0005615 GO:0030246 GO:0070062
GL_001363	Beta-glucuronidase	P08236	Homo sapiens	9606	azurophil granule lumen beta-glucuronidase activity carbohydrate binding carbohydrate metabolic process chondroitin sulfate catabolic process extracellular exosome extracellular region extracellular space ficolin-1-rich granule lumen glucuronoside catabolic process glycosaminoglycan catabolic process heparan sulfate proteoglycan catabolic process hyaluronan catabolic process intracellular membrane-bounded organelle lysosomal lumen membrane protein domain specific binding signaling receptor binding	GO:0004566 GO:0005102 GO:0005576 GO:0005615 GO:0005975 GO:0006027 GO:0016020 GO:0019391 GO:0019904 GO:0030200 GO:0030207 GO:0030214 GO:0030246 GO:0035578 GO:0043202 GO:0043231 GO:0070062 GO:1904813
GL_000880	Polycystin-1-like protein 3	Q7Z443	Homo sapiens	9606	calcium channel activity carbohydrate binding cation channel complex cellular response to acidic pH detection of chemical stimulus involved in sensory perception of sour taste detection of mechanical stimulus extracellular exosome kidney development membrane monoatomic cation transport plasma membrane receptor complex sensory perception of sour taste	GO:0001581 GO:0001822 GO:0005262 GO:0005886 GO:0006812 GO:0016020 GO:0030246 GO:0034703 GO:0043235 GO:0050915 GO:0050982 GO:0070062 GO:0071468