GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	UniProt ID	Monosaccharide Specificities	Species	Taxonomy ID	GO Labels ▼	GO IDs
GL_001382	CD209 antigen	Q9NNX6	Man	Homo sapiens	9606	B cell adhesion adaptive immune response antigen processing and presentation carbohydrate binding cell surface cell-cell recognition cytoplasm endocytosis external side of plasma membrane extracellular region heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules host cell immune response innate immune response intracellular signal transduction intracellular transport of virus leukocyte cell-cell adhesion mannose binding membrane metal ion binding peptide antigen binding peptide antigen transport plasma membrane positive regulation of T cell proliferation positive regulation of viral life cycle regulation of T cell proliferation viral entry into host cell viral genome replication virion attachment to host cell virion binding virus receptor activity	GO:0001618 GO:0002250 GO:0005537 GO:0005576 GO:0005737 GO:0005886 GO:0006897 GO:0006955 GO:0007157 GO:0007159 GO:0009897 GO:0009986 GO:0009988 GO:0016020 GO:0019062 GO:0019079 GO:0019882 GO:0030246 GO:0035556 GO:0042102 GO:0042129 GO:0042605 GO:0043657 GO:0045087 GO:0046718 GO:0046790 GO:0046872 GO:0046968 GO:0075733 GO:0097323 GO:1903902
GL_000081	B-cell receptor CD22	Q9N1E5		Pan paniscus	9597	B cell activation CD4 receptor binding carbohydrate binding cell adhesion early endosome external side of plasma membrane negative regulation of B cell receptor signaling pathway negative regulation of calcium-mediated signaling negative regulation of immunoglobulin production neuronal cell body membrane protein phosphatase binding recycling endosome regulation of B cell proliferation regulation of endocytosis sialic acid binding	GO:0002638 GO:0005769 GO:0007155 GO:0009897 GO:0019903 GO:0030100 GO:0030246 GO:0030888 GO:0032809 GO:0033691 GO:0042113 GO:0042609 GO:0050849 GO:0050859 GO:0055037
GL_000080	B-cell receptor CD22	Q9N1E6		Pan troglodytes	9598	B cell activation CD4 receptor binding carbohydrate binding cell adhesion early endosome external side of plasma membrane negative regulation of B cell receptor signaling pathway negative regulation of calcium-mediated signaling negative regulation of immunoglobulin production neuronal cell body membrane protein phosphatase binding recycling endosome regulation of B cell proliferation regulation of endocytosis sialic acid binding	GO:0002638 GO:0005769 GO:0007155 GO:0009897 GO:0019903 GO:0030100 GO:0030246 GO:0030888 GO:0032809 GO:0033691 GO:0042113 GO:0042609 GO:0050849 GO:0050859 GO:0055037
GL_000078	B-cell receptor CD22	P35329		Mus musculus	10090	B cell activation CD4 receptor binding carbohydrate binding cell adhesion cell surface cell surface receptor signaling pathway coreceptor activity early endosome external side of plasma membrane negative regulation of B cell receptor signaling pathway negative regulation of calcium-mediated signaling negative regulation of immunoglobulin production neuronal cell body membrane plasma membrane protein phosphatase binding recycling endosome regulation of B cell proliferation regulation of endocytosis regulation of immune response sialic acid binding	GO:0002638 GO:0005769 GO:0005886 GO:0007155 GO:0007166 GO:0009897 GO:0009986 GO:0015026 GO:0019903 GO:0030100 GO:0030246 GO:0030888 GO:0032809 GO:0033691 GO:0042113 GO:0042609 GO:0050776 GO:0050849 GO:0050859 GO:0055037
GL_000082	B-cell receptor CD22	P20273		Homo sapiens	9606	B cell activation CD4 receptor binding IgM binding carbohydrate binding cell adhesion cell surface cytoplasm early endosome external side of plasma membrane extracellular exosome membrane negative regulation of B cell receptor signaling pathway negative regulation of calcium-mediated signaling negative regulation of immunoglobulin production neuronal cell body membrane plasma membrane protein phosphatase binding recycling endosome regulation of B cell proliferation regulation of endocytosis regulation of immune response sialic acid binding signaling receptor binding	GO:0001791 GO:0002638 GO:0005102 GO:0005737 GO:0005769 GO:0005886 GO:0007155 GO:0009897 GO:0009986 GO:0016020 GO:0019903 GO:0030100 GO:0030246 GO:0030888 GO:0032809 GO:0033691 GO:0042113 GO:0042609 GO:0050776 GO:0050849 GO:0050859 GO:0055037 GO:0070062
GL_002375	Coxsackievirus and adenovirus receptor	P78310		Homo sapiens	9606	AV node cell to bundle of His cell communication AV node cell-bundle of His cell adhesion involved in cell communication PDZ domain binding acrosomal vesicle actin cytoskeleton organization adherens junction apicolateral plasma membrane basolateral plasma membrane beta-catenin binding bicellular tight junction cardiac muscle cell development cell adhesion molecule binding cell adhesive protein binding involved in AV node cell-bundle of His cell communication cell body cell junction cell-cell junction cell-cell junction organization connexin binding cytoplasm defense response to virus epithelial structure maintenance extracellular region extracellular space filopodium gamma-delta T cell activation germ cell migration growth cone heart development heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules homotypic cell-cell adhesion identical protein binding integrin binding intercalated disc membrane raft mitochondrion organization neuromuscular junction neuron projection neutrophil chemotaxis nucleoplasm plasma membrane protein-containing complex regulation of AV node cell action potential signaling receptor binding transepithelial transport virus receptor activity	GO:0001618 GO:0001669 GO:0005102 GO:0005178 GO:0005576 GO:0005615 GO:0005654 GO:0005737 GO:0005886 GO:0005911 GO:0005912 GO:0005923 GO:0007005 GO:0007157 GO:0007507 GO:0008013 GO:0008354 GO:0010669 GO:0014704 GO:0016323 GO:0016327 GO:0030036 GO:0030054 GO:0030165 GO:0030175 GO:0030426 GO:0030593 GO:0031594 GO:0032991 GO:0034109 GO:0042802 GO:0043005 GO:0044297 GO:0045121 GO:0045216 GO:0046629 GO:0050839 GO:0051607 GO:0055013 GO:0070633 GO:0071253 GO:0086067 GO:0086072 GO:0086082 GO:0098904
GL_001193	ABC transporter periplasmic-binding protein YphF	P77269		Escherichia coli K-12	83333	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing carbohydrate binding membrane outer membrane-bounded periplasmic space transmembrane transport	GO:0016020 GO:0030246 GO:0030288 GO:0055052 GO:0055085
GL_001422	D-galactose/methyl-galactoside binding periplasmic protein MglB	P0AEE5		Escherichia coli K-12	83333	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing calcium ion binding carbohydrate binding chemotaxis galactose transmembrane transport membrane methylgalactoside transport outer membrane-bounded periplasmic space	GO:0005509 GO:0006935 GO:0015757 GO:0015765 GO:0016020 GO:0030246 GO:0030288 GO:0055052
GL_001430	D-xylose-binding periplasmic protein	P37387		Escherichia coli K-12	83333	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing D-xylose metabolic process D-xylose transmembrane transport carbohydrate binding membrane monosaccharide binding outer membrane-bounded periplasmic space	GO:0015753 GO:0016020 GO:0030246 GO:0030288 GO:0042732 GO:0048029 GO:0055052
GL_001263	Autoinducer 2-binding protein LsrB	Q74PW2		Yersinia pestis	632	ATP-binding cassette (ABC) transporter complex carbohydrate binding outer membrane-bounded periplasmic space	GO:0030246 GO:0030288 GO:0043190