GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	UniProt ID	Species	Taxonomy ID ▼	GO Labels	GO IDs
GL_000624	Killer cell lectin-like receptor subfamily E member 1	Q8CJC7	Mus musculus	10090	carbohydrate binding cell surface external side of plasma membrane identical protein binding natural killer cell activation negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target plasma membrane positive regulation of natural killer cell mediated cytotoxicity positive regulation of type II interferon production protein phosphatase binding stimulatory C-type lectin receptor signaling pathway transmembrane signaling receptor activity	GO:0002223 GO:0002859 GO:0004888 GO:0005886 GO:0009897 GO:0009986 GO:0019903 GO:0030101 GO:0030246 GO:0032729 GO:0042802 GO:0045954
GL_001017	Pulmonary surfactant-associated protein A	P35242	Mus musculus	10090	carbohydrate binding collagen trimer collagen-containing extracellular matrix extracellular space metal ion binding multivesicular body positive regulation of phagocytosis respiratory gaseous exchange by respiratory system	GO:0005581 GO:0005615 GO:0005771 GO:0007585 GO:0030246 GO:0046872 GO:0050766 GO:0062023
GL_001370	Beta-hexosaminidase subunit beta	P20060	Mus musculus	10090	N-acetyl-beta-D-galactosaminidase activity N-acetylglucosamine metabolic process acetylglucosaminyltransferase activity acrosomal vesicle astrocyte cell migration azurophil granule beta-N-acetylglucosaminidase activity beta-N-acetylhexosaminidase activity beta-N-acetylhexosaminidase complex carbohydrate binding chondroitin sulfate catabolic process cortical granule dermatan sulfate catabolic process extracellular space ganglioside catabolic process glycosaminoglycan metabolic process glycosphingolipid metabolic process hexosaminidase activity hyaluronan catabolic process hydrolase activity identical protein binding intracellular calcium ion homeostasis lipid storage locomotory behavior lysosomal lumen lysosome lysosome organization maintenance of location in cell male courtship behavior membrane myelination neuromuscular process neuromuscular process controlling balance neuron cellular homeostasis oligosaccharide catabolic process oogenesis penetration of zona pellucida phospholipid biosynthetic process positive regulation of transcription by RNA polymerase II protein metabolic process protein-containing complex binding regulation of cell shape sensory perception of sound sexual reproduction single fertilization skeletal system development	GO:0001501 GO:0001669 GO:0004563 GO:0005615 GO:0005764 GO:0006044 GO:0006687 GO:0006689 GO:0006874 GO:0007040 GO:0007338 GO:0007341 GO:0007605 GO:0007626 GO:0008049 GO:0008360 GO:0008375 GO:0008654 GO:0009313 GO:0015929 GO:0016020 GO:0016231 GO:0016787 GO:0019538 GO:0019915 GO:0019953 GO:0030203 GO:0030207 GO:0030209 GO:0030214 GO:0030246 GO:0042552 GO:0042582 GO:0042802 GO:0043202 GO:0043615 GO:0044877 GO:0045944 GO:0048477 GO:0050885 GO:0050905 GO:0051651 GO:0060473 GO:0070050 GO:0102148 GO:1905379
GL_000182	C-type lectin domain family 4 member E	Q9R0Q8	Mus musculus	10090	Fc-gamma receptor signaling pathway T cell differentiation involved in immune response antifungal innate immune response calcium ion binding carbohydrate binding cell projection defense response to bacterium external side of plasma membrane glycolipid binding immune response innate immune response membrane pattern recognition receptor activity pattern recognition receptor signaling pathway phagocytic cup phagocytic vesicle membrane plasma membrane positive regulation of cytokine production signaling receptor activity	GO:0001819 GO:0001891 GO:0002221 GO:0002292 GO:0005509 GO:0005886 GO:0006955 GO:0009897 GO:0016020 GO:0030246 GO:0030670 GO:0038023 GO:0038094 GO:0038187 GO:0042742 GO:0042995 GO:0045087 GO:0051861 GO:0061760
GL_000014	Adhesion G protein-coupled receptor L1	Q80TR1	Mus musculus	10090	G protein-coupled receptor activity adenylate cyclase-activating G protein-coupled receptor signaling pathway axon calcium-mediated signaling using intracellular calcium source carbohydrate binding cell adhesion molecule binding cell surface receptor signaling pathway glutamatergic synapse growth cone heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules latrotoxin receptor activity neuron projection plasma membrane positive regulation of synapse assembly positive regulation of synapse maturation presynaptic membrane synapse toxic substance binding	GO:0004930 GO:0005886 GO:0007157 GO:0007166 GO:0007189 GO:0015643 GO:0016524 GO:0030246 GO:0030424 GO:0030426 GO:0035584 GO:0042734 GO:0043005 GO:0045202 GO:0050839 GO:0051965 GO:0090129 GO:0098978
GL_000780	Myelin-associated glycoprotein	P20917	Mus musculus	10090	Schmidt-Lanterman incisure axon regeneration carbohydrate binding cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules cellular response to mechanical stimulus central nervous system myelin formation central nervous system myelination compact myelin ganglioside GT1b binding membrane raft mesaxon myelin sheath myelin sheath adaxonal region myelination negative regulation of axon extension negative regulation of neuron apoptotic process negative regulation of neuron differentiation negative regulation of neuron projection development paranode region of axon plasma membrane positive regulation of astrocyte differentiation positive regulation of myelination protein homodimerization activity protein kinase binding sialic acid binding signaling receptor binding transmission of nerve impulse	GO:0005102 GO:0005886 GO:0007155 GO:0010977 GO:0019226 GO:0019901 GO:0022010 GO:0030246 GO:0030517 GO:0031103 GO:0031643 GO:0032289 GO:0033270 GO:0033691 GO:0035749 GO:0042552 GO:0042803 GO:0043209 GO:0043218 GO:0043220 GO:0043524 GO:0045121 GO:0045665 GO:0048711 GO:0071260 GO:0097453 GO:0098742 GO:1905576
GL_001692	Lysosomal alpha-glucosidase	P70699	Mus musculus	10090	alpha-1,4-glucosidase activity alpha-glucosidase activity aorta development autolysosome lumen carbohydrate binding cardiac muscle contraction diaphragm contraction glucan 1,6-alpha-glucosidase activity glycogen catabolic process glycogen metabolic process glycophagy heart morphogenesis intracellular membrane-bounded organelle locomotory behavior lysosomal membrane lysosome lysosome organization maltose alpha-glucosidase activity membrane muscle cell cellular homeostasis neuromuscular process controlling balance neuromuscular process controlling posture regulation of the force of heart contraction striated muscle contraction tissue development vacuolar sequestering	GO:0002026 GO:0002086 GO:0003007 GO:0004558 GO:0005764 GO:0005765 GO:0005977 GO:0005980 GO:0006941 GO:0007040 GO:0007626 GO:0009888 GO:0016020 GO:0030246 GO:0032450 GO:0035904 GO:0043181 GO:0043231 GO:0043896 GO:0046716 GO:0050884 GO:0050885 GO:0060048 GO:0061723 GO:0090599 GO:0120282
GL_000193	C-type lectin domain family 6 member A	Q9JKF4	Mus musculus	10090	adaptive immune response antifungal innate immune response calcium ion binding carbohydrate binding defense response to fungus detection of yeast external side of plasma membrane innate immune response mannose binding pattern recognition receptor activity plasma membrane positive regulation of T-helper 17 type immune response positive regulation of canonical NF-kappaB signal transduction positive regulation of cytokine production positive regulation of intracellular signal transduction positive regulation of peptidyl-tyrosine phosphorylation response to yeast stimulatory C-type lectin receptor signaling pathway	GO:0001819 GO:0001878 GO:0001879 GO:0002223 GO:0002250 GO:0005509 GO:0005537 GO:0005886 GO:0009897 GO:0030246 GO:0038187 GO:0043123 GO:0045087 GO:0050731 GO:0050832 GO:0061760 GO:1902533 GO:2000318
GL_000154	C-type lectin domain family 2 member D	Q91V08	Mus musculus	10090	carbohydrate binding cell surface cellular defense response endoplasmic reticulum external side of plasma membrane natural killer cell lectin-like receptor binding negative regulation of osteoclast differentiation plasma membrane protection from natural killer cell mediated cytotoxicity transmembrane signaling receptor activity	GO:0004888 GO:0005783 GO:0005886 GO:0006968 GO:0009897 GO:0009986 GO:0030246 GO:0042270 GO:0045671 GO:0046703
GL_000875	Polycystin-1	O08852	Mus musculus	10090	Golgi apparatus Wnt receptor activity basolateral plasma membrane blood vessel development branching morphogenesis of an epithelial tube calcium channel activity calcium channel complex calcium ion transmembrane transport calcium ion transport carbohydrate binding cartilage condensation cation channel complex cell surface cell-cell adhesion cell-cell signaling by wnt cilium cytoplasm detection of mechanical stimulus digestive tract development embryonic placenta development endoplasmic reticulum establishment of epithelial cell polarity extracellular exosome genitalia development heart development in utero embryonic development kidney development lateral plasma membrane liver development lung epithelium development lymph vessel morphogenesis membrane mesonephric duct development metanephric ascending thin limb development metanephric collecting duct development metanephric distal tubule morphogenesis metanephric proximal tubule development monoatomic cation channel activity motile cilium neural tube development nitrogen compound metabolic process nucleus peptidyl-serine phosphorylation placenta blood vessel development plasma membrane polycystin complex positive regulation of cytosolic calcium ion concentration positive regulation of transcription by RNA polymerase II protein domain specific binding protein export from nucleus protein heterotetramerization protein kinase binding receptor signaling pathway via JAK-STAT regulation of G1/S transition of mitotic cell cycle regulation of cell adhesion regulation of cell cycle regulation of mitotic spindle organization regulation of proteasomal protein catabolic process response to fluid shear stress skin development spinal cord development transcription regulator inhibitor activity transmembrane transporter binding	GO:0001502 GO:0001568 GO:0001701 GO:0001822 GO:0001889 GO:0001892 GO:0002133 GO:0005261 GO:0005262 GO:0005634 GO:0005737 GO:0005783 GO:0005794 GO:0005886 GO:0005929 GO:0006611 GO:0006807 GO:0006816 GO:0007204 GO:0007259 GO:0007507 GO:0009986 GO:0016020 GO:0016323 GO:0016328 GO:0018105 GO:0019901 GO:0019904 GO:0021510 GO:0021915 GO:0030155 GO:0030246 GO:0031514 GO:0034405 GO:0034703 GO:0034704 GO:0036303 GO:0042813 GO:0043588 GO:0044325 GO:0045944 GO:0048565 GO:0048754 GO:0048806 GO:0050982 GO:0051290 GO:0051726 GO:0060236 GO:0060428 GO:0060674 GO:0061136 GO:0070062 GO:0070588 GO:0072177 GO:0072205 GO:0072218 GO:0072237 GO:0072287 GO:0090162 GO:0098609 GO:0140416 GO:0198738 GO:2000045