GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	UniProt ID	Species	Taxonomy ID ▼	GO Labels	GO IDs
GL_000512	Galectin-9	O08573	Mus musculus	10090	carbohydrate binding cellular response to virus chemotaxis collagen-containing extracellular matrix cytoplasm cytosol disaccharide binding enzyme binding extracellular region extracellular space female pregnancy galactoside binding heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules immune system process maintenance of protein location negative regulation of CD4-positive, alpha-beta T cell proliferation negative regulation of gene expression negative regulation of inflammatory response negative regulation of natural killer cell activation negative regulation of natural killer cell degranulation negative regulation of type II interferon production nucleus plasma membrane positive regulation of SMAD protein signal transduction positive regulation of T cell migration positive regulation of chemokine production positive regulation of cytokine production positive regulation of defense response to bacterium positive regulation of gene expression positive regulation of innate immune response positive regulation of interleukin-1 production positive regulation of interleukin-10 production positive regulation of interleukin-6 production positive regulation of macrophage activation positive regulation of oxidoreductase activity positive regulation of regulatory T cell differentiation positive regulation of tumor necrosis factor production protein serine/threonine kinase activator activity receptor clustering regulation of natural killer cell differentiation response to lipopolysaccharide signaling receptor binding transforming growth factor beta receptor signaling pathway	GO:0001819 GO:0002376 GO:0005102 GO:0005576 GO:0005615 GO:0005634 GO:0005737 GO:0005829 GO:0005886 GO:0006935 GO:0007157 GO:0007179 GO:0007565 GO:0010628 GO:0010629 GO:0016936 GO:0019899 GO:0030246 GO:0032496 GO:0032689 GO:0032722 GO:0032732 GO:0032733 GO:0032755 GO:0032760 GO:0032815 GO:0032823 GO:0043032 GO:0043113 GO:0043322 GO:0043539 GO:0045089 GO:0045185 GO:0045591 GO:0048030 GO:0050728 GO:0051353 GO:0060391 GO:0062023 GO:0098586 GO:1900426 GO:2000406 GO:2000562
GL_001362	Beta-glucuronidase	P12265	Mus musculus	10090	beta-glucuronidase activity carbohydrate binding carbohydrate metabolic process chondroitin sulfate catabolic process endoplasmic reticulum extracellular space glucuronoside catabolic process heparan sulfate proteoglycan catabolic process hyaluronan catabolic process hydrolase activity intracellular membrane-bounded organelle lysosomal lumen lysosome protein domain specific binding signaling receptor binding	GO:0004566 GO:0005102 GO:0005615 GO:0005764 GO:0005783 GO:0005975 GO:0016787 GO:0019391 GO:0019904 GO:0030200 GO:0030207 GO:0030214 GO:0030246 GO:0043202 GO:0043231
GL_001866	Transketolase	P40142	Mus musculus	10090	calcium ion binding carbohydrate binding cytosol endoplasmic reticulum membrane glyceraldehyde-3-phosphate biosynthetic process magnesium ion binding monosaccharide binding myelin sheath nuclear body nucleoplasm pentose-phosphate shunt pentose-phosphate shunt, non-oxidative branch peroxisome protein homodimerization activity regulation of growth thiamine pyrophosphate binding transketolase activity xylulose 5-phosphate biosynthetic process	GO:0000287 GO:0004802 GO:0005509 GO:0005654 GO:0005777 GO:0005789 GO:0005829 GO:0006098 GO:0009052 GO:0016604 GO:0030246 GO:0030976 GO:0040008 GO:0042803 GO:0043209 GO:0046166 GO:0048029 GO:1901159
GL_001135	T-cell surface glycoprotein YE1/48	P20937	Mus musculus	10090	carbohydrate binding cell adhesion external side of plasma membrane plasma membrane signaling receptor activity	GO:0005886 GO:0007155 GO:0009897 GO:0030246 GO:0038023
GL_000617	Killer cell lectin-like receptor subfamily B member 1B allele B	Q99JB4	Mus musculus	10090	carbohydrate binding cell surface external side of plasma membrane identical protein binding negative regulation of natural killer cell mediated cytotoxicity plasma membrane regulation of natural killer cell mediated cytotoxicity signaling receptor activity	GO:0005886 GO:0009897 GO:0009986 GO:0030246 GO:0038023 GO:0042269 GO:0042802 GO:0045953
GL_001644	Glycogen phosphorylase, muscle form	Q9WUB3	Mus musculus	10090	AMP binding SHG alpha-glucan phosphorylase activity Z disc carbohydrate binding cytoplasm glycogen catabolic process glycogen metabolic process glycogen phosphorylase activity intracellular calcium ion homeostasis linear malto-oligosaccharide phosphorylase activity organic cyclic compound binding pyridoxal phosphate binding response to cAMP response to hypoxia response to organic substance sarcoplasmic reticulum	GO:0001666 GO:0005737 GO:0005977 GO:0005980 GO:0006874 GO:0008184 GO:0010033 GO:0016208 GO:0016529 GO:0030018 GO:0030170 GO:0030246 GO:0051591 GO:0097159 GO:0102250 GO:0102499
GL_002074	Sialic acid-binding Ig-like lectin 5	Q920G3	Mus musculus	10090	cell adhesion lysosome monosaccharide binding plasma membrane regulation of endocytosis sialic acid binding	GO:0005764 GO:0005886 GO:0007155 GO:0030100 GO:0033691 GO:0048029
GL_002040	Lithostathine-1	P43137	Mus musculus	10090	antimicrobial humoral immune response mediated by antimicrobial peptide basal part of cell cellular response to chemokine cellular response to gastrin collagen-containing extracellular matrix dendrite membrane extracellular space gene expression growth cone growth factor activity identical protein binding liver regeneration midgut development molecular function inhibitor activity negative regulation of cell population proliferation neuronal cell body membrane oligosaccharide binding pancreas regeneration peptidoglycan binding perinuclear region of cytoplasm phosphatase binding phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of acinar cell proliferation positive regulation of cell population proliferation positive regulation of dendrite extension positive regulation of gene expression positive regulation of protein phosphorylation positive regulation of type B pancreatic cell proliferation protein phosphatase binding protein-containing complex response to growth hormone-releasing hormone response to hypoxia response to nutrient levels response to organic cyclic compound response to peptide hormone response to water-immersion restraint stress signaling receptor activity signaling receptor binding type B pancreatic cell differentiation zymogen granule	GO:0001666 GO:0001934 GO:0003309 GO:0005102 GO:0005615 GO:0007494 GO:0008083 GO:0008284 GO:0008285 GO:0010467 GO:0010628 GO:0014070 GO:0019902 GO:0019903 GO:0030426 GO:0031667 GO:0032590 GO:0032809 GO:0032991 GO:0038023 GO:0042588 GO:0042802 GO:0042834 GO:0043434 GO:0043491 GO:0045178 GO:0048471 GO:0061844 GO:0062023 GO:0070492 GO:0097421 GO:0140678 GO:1903861 GO:1904692 GO:1904699 GO:1990785 GO:1990798 GO:1990864 GO:1990869 GO:1990878
GL_000801	Natural killer cells antigen CD94	O54707	Mus musculus	10090	HLA-E specific inhibitory MHC class Ib receptor activity MHC class I protein complex binding MHC class Ib protein binding, via antigen binding groove adaptive immune response carbohydrate binding external side of plasma membrane natural killer cell mediated immunity negative regulation of T cell mediated cytotoxicity negative regulation of natural killer cell mediated cytotoxicity plasma membrane positive regulation of natural killer cell mediated cytotoxicity protein antigen binding receptor complex regulation of natural killer cell activation stimulatory C-type lectin receptor signaling pathway transmembrane signaling receptor activity	GO:0001915 GO:0002223 GO:0002228 GO:0002250 GO:0004888 GO:0005886 GO:0009897 GO:0023024 GO:0023030 GO:0030246 GO:0032814 GO:0043235 GO:0045953 GO:0045954 GO:0062082 GO:1990405
GL_001145	Tetranectin	P43025	Mus musculus	10090	bone mineralization calcium ion binding carbohydrate binding cytoplasm extracellular matrix extracellular space granular component heparin binding kringle domain binding ossification positive regulation of plasminogen activation skeletal system development	GO:0001501 GO:0001503 GO:0001652 GO:0005509 GO:0005615 GO:0005737 GO:0008201 GO:0010756 GO:0030246 GO:0030282 GO:0031012 GO:0036143