GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	UniProt ID	Species	Taxonomy ID ▲	GO Labels	GO IDs
GL_001117	Sialic acid-binding Ig-like lectin 14	Q08ET2	Homo sapiens	9606	carbohydrate binding cell adhesion ficolin-1-rich granule membrane plasma membrane sialic acid binding tertiary granule membrane	GO:0005886 GO:0007155 GO:0030246 GO:0033691 GO:0070821 GO:0101003
GL_000272	Calreticulin	P27797	Homo sapiens	9606	DNA binding MHC class I peptide loading complex RNA binding acrosomal vesicle calcium ion binding carbohydrate binding cardiac muscle cell differentiation cell surface cellular response to electrical stimulus cellular response to lithium ion cellular response to virus cellular senescence collagen-containing extracellular matrix complement component C1q complex binding cortical actin cytoskeleton organization cortical granule cytolytic granule cytoplasm cytosol endocytic vesicle lumen endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum quality control compartment endoplasmic reticulum-Golgi intermediate compartment membrane external side of plasma membrane extracellular exosome extracellular region extracellular space focal adhesion glucocorticoid receptor signaling pathway hormone binding integrin binding intracellular calcium ion homeostasis iron ion binding lumenal side of endoplasmic reticulum membrane mRNA binding membrane negative regulation of DNA-templated transcription negative regulation of intracellular steroid hormone receptor signaling pathway negative regulation of neuron differentiation negative regulation of retinoic acid receptor signaling pathway negative regulation of transcription by RNA polymerase II negative regulation of translation negative regulation of trophoblast cell migration nuclear androgen receptor binding nuclear envelope nuclear export signal receptor activity nucleus obsolete selective autophagy peptide antigen assembly with MHC class I protein complex peptide binding perinuclear region of cytoplasm phagocytic vesicle membrane polysome positive regulation of cell cycle positive regulation of cell population proliferation positive regulation of dendritic cell chemotaxis positive regulation of endothelial cell migration positive regulation of gene expression positive regulation of non-canonical NF-kappaB signal transduction positive regulation of phagocytosis positive regulation of substrate adhesion-dependent cell spreading protein export from nucleus protein folding protein folding chaperone protein folding in endoplasmic reticulum protein localization to nucleus protein maturation by protein folding protein stabilization protein-folding chaperone binding regulation of DNA-templated transcription regulation of apoptotic process regulation of meiotic nuclear division response to estradiol response to glycoside response to testosterone response to xenobiotic stimulus sarcoplasmic reticulum lumen sequestering of calcium ion smooth endoplasmic reticulum spermatogenesis ubiquitin protein ligase binding ubiquitin-dependent ERAD pathway unfolded protein binding zinc ion binding	GO:0000122 GO:0001669 GO:0001849 GO:0002502 GO:0003677 GO:0003723 GO:0003729 GO:0005049 GO:0005178 GO:0005506 GO:0005509 GO:0005576 GO:0005615 GO:0005634 GO:0005635 GO:0005737 GO:0005783 GO:0005788 GO:0005789 GO:0005790 GO:0005829 GO:0005844 GO:0005925 GO:0006355 GO:0006457 GO:0006611 GO:0006874 GO:0007283 GO:0008270 GO:0008284 GO:0009410 GO:0009897 GO:0009986 GO:0010595 GO:0010628 GO:0016020 GO:0017148 GO:0022417 GO:0030246 GO:0030433 GO:0030670 GO:0030866 GO:0031625 GO:0032355 GO:0033018 GO:0033116 GO:0033144 GO:0033574 GO:0034504 GO:0034975 GO:0040020 GO:0042277 GO:0042562 GO:0042824 GO:0042921 GO:0042981 GO:0044183 GO:0044194 GO:0044322 GO:0045665 GO:0045787 GO:0045892 GO:0048387 GO:0048471 GO:0050681 GO:0050766 GO:0050821 GO:0051082 GO:0051087 GO:0051208 GO:0055007 GO:0060473 GO:0061912 GO:0062023 GO:0070062 GO:0071257 GO:0071285 GO:0071682 GO:0090398 GO:0098553 GO:0098586 GO:1900026 GO:1901164 GO:1901224 GO:1903416 GO:2000510
GL_001020	Pulmonary surfactant-associated protein A1	Q8IWL2	Homo sapiens	9606	carbohydrate binding clathrin-coated endocytic vesicle collagen trimer endoplasmic reticulum membrane extracellular region extracellular space lamellar body lipid transporter activity multivesicular body opsonization respiratory gaseous exchange by respiratory system	GO:0005319 GO:0005576 GO:0005581 GO:0005615 GO:0005771 GO:0005789 GO:0007585 GO:0008228 GO:0030246 GO:0042599 GO:0045334
GL_002325	T-cell surface antigen CD2	P06729	Homo sapiens	9606	Golgi apparatus T cell activation apoptotic process cell surface cell surface receptor signaling pathway cell-cell adhesion cell-cell junction cytoplasmic side of plasma membrane external side of plasma membrane extracellular region heterotypic cell-cell adhesion identical protein binding membrane raft polarization natural killer cell activation natural killer cell mediated cytotoxicity nucleoplasm plasma membrane positive regulation of interleukin-8 production positive regulation of myeloid dendritic cell activation positive regulation of tumor necrosis factor production positive regulation of type II interferon production protein self-association protein-containing complex receptor tyrosine kinase binding regulation of T cell differentiation signaling receptor activity signaling receptor binding	GO:0001766 GO:0005102 GO:0005576 GO:0005654 GO:0005794 GO:0005886 GO:0005911 GO:0006915 GO:0007166 GO:0009897 GO:0009898 GO:0009986 GO:0030101 GO:0030887 GO:0030971 GO:0032729 GO:0032757 GO:0032760 GO:0032991 GO:0034113 GO:0038023 GO:0042110 GO:0042267 GO:0042802 GO:0043621 GO:0045580 GO:0098609
GL_001413	Complement C4-B	P0C0L5	Homo sapiens	9606	axon blood microparticle carbohydrate binding complement activation complement activation, classical pathway complement binding dendrite detection of molecule of bacterial origin endopeptidase inhibitor activity extracellular exosome extracellular region extracellular space inflammatory response innate immune response opsonization plasma membrane positive regulation of apoptotic cell clearance symbiont cell surface synapse	GO:0001848 GO:0004866 GO:0005576 GO:0005615 GO:0005886 GO:0006954 GO:0006956 GO:0006958 GO:0008228 GO:0030246 GO:0030424 GO:0030425 GO:0032490 GO:0045087 GO:0045202 GO:0070062 GO:0072562 GO:0106139 GO:2000427
GL_002002	E-selectin	P16581	Homo sapiens	9606	actin filament-based process activation of phospholipase C activity calcium-mediated signaling caveola clathrin-coated pit cortical cytoskeleton external side of plasma membrane extracellular space heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules inflammatory response leukocyte cell-cell adhesion leukocyte migration involved in inflammatory response leukocyte tethering or rolling membrane raft metal ion binding oligosaccharide binding perinuclear region of cytoplasm phospholipase binding plasma membrane positive regulation of leukocyte migration positive regulation of leukocyte tethering or rolling positive regulation of receptor internalization regulation of inflammatory response response to cytokine response to interleukin-1 response to lipopolysaccharide response to tumor necrosis factor sialic acid binding transmembrane signaling receptor activity	GO:0002092 GO:0002523 GO:0002687 GO:0004888 GO:0005615 GO:0005886 GO:0005901 GO:0005905 GO:0006954 GO:0007157 GO:0007159 GO:0007202 GO:0009897 GO:0019722 GO:0030029 GO:0030863 GO:0032496 GO:0033691 GO:0034097 GO:0034612 GO:0043274 GO:0045121 GO:0046872 GO:0048471 GO:0050727 GO:0050901 GO:0070492 GO:0070555 GO:1903238
GL_000304	Cell migration-inducing and hyaluronan-binding protein	Q8WUJ3	Homo sapiens	9606	ER retention sequence binding carbohydrate binding clathrin heavy chain binding clathrin-coated endocytic vesicle clathrin-coated pit clathrin-coated vesicle membrane cytoplasm endoplasmic reticulum extracellular region fibrillar center hyaluronan biosynthetic process hyaluronan catabolic process hyaluronic acid binding hyalurononglucosaminidase activity nuclear membrane plasma membrane positive regulation of cell migration positive regulation of peptidyl-threonine phosphorylation positive regulation of protein kinase C activity positive regulation of protein targeting to membrane positive regulation of release of sequestered calcium ion into cytosol sensory perception of sound	GO:0001650 GO:0004415 GO:0005540 GO:0005576 GO:0005737 GO:0005783 GO:0005886 GO:0005905 GO:0007605 GO:0010800 GO:0030213 GO:0030214 GO:0030246 GO:0030335 GO:0030665 GO:0031965 GO:0032050 GO:0045334 GO:0046923 GO:0051281 GO:0090314 GO:1900020
GL_000908	Polypeptide N-acetylgalactosaminyltransferase 18	Q6P9A2	Homo sapiens	9606	Golgi apparatus Golgi membrane carbohydrate binding metal ion binding polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation	GO:0000139 GO:0004653 GO:0005794 GO:0006493 GO:0030246 GO:0046872
GL_000299	CD302 antigen	Q8IX05	Homo sapiens	9606	carbohydrate binding cell cortex external side of plasma membrane filopodium membrane microvillus phagocytosis signaling receptor activity	GO:0005902 GO:0005938 GO:0006909 GO:0009897 GO:0016020 GO:0030175 GO:0030246 GO:0038023
GL_000519	Galectin-related protein	Q3ZCW2	Homo sapiens	9606	carbohydrate binding	GO:0030246