GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	UniProt ID	Monosaccharide Specificities	Species	Taxonomy ID ▲	GO Labels	GO IDs
GL_000363	Endosialin	Q9HCU0		Homo sapiens	9606	anatomical structure regression calcium ion binding carbohydrate binding cell migration cytoplasm endothelial cell apoptotic process external side of plasma membrane extracellular exosome extracellular matrix extracellular matrix binding extracellular matrix protein binding fibroblast migration fibroblast proliferation lymph node development positive regulation of endothelial cell apoptotic process positive regulation of fibroblast proliferation	GO:0005509 GO:0005737 GO:0009897 GO:0010761 GO:0016477 GO:0030246 GO:0031012 GO:0048144 GO:0048146 GO:0048535 GO:0050840 GO:0060033 GO:0070062 GO:0072577 GO:1990430 GO:2000353
GL_001477	F-box only protein 6	Q9NRD1		Homo sapiens	9606	DNA damage checkpoint signaling DNA repair SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process carbohydrate binding cytoplasm cytosol endoplasmic reticulum quality control compartment glycoprotein catabolic process protein ubiquitination proteolysis response to unfolded protein ubiquitin protein ligase activity ubiquitin-dependent ERAD pathway	GO:0000077 GO:0005737 GO:0005829 GO:0006281 GO:0006508 GO:0006516 GO:0006986 GO:0016567 GO:0019005 GO:0030246 GO:0030433 GO:0031146 GO:0044322 GO:0061630
GL_000384	Ficolin-1	O00602		Homo sapiens	9606	G protein-coupled receptor binding G protein-coupled receptor signaling pathway antigen binding carbohydrate binding carbohydrate derivative binding cell surface pattern recognition receptor signaling pathway collagen trimer collagen-containing extracellular matrix complement activation, lectin pathway external side of plasma membrane extracellular region extracellular space ficolin-1-rich granule lumen metal ion binding negative regulation of viral entry into host cell pattern recognition receptor activity plasma membrane positive regulation of interleukin-8 production positive regulation of opsonization protein localization to cell surface proteolysis recognition of apoptotic cell secretory granule lumen serine-type endopeptidase complex sialic acid binding signaling receptor binding	GO:0001664 GO:0001867 GO:0002752 GO:0003823 GO:0005102 GO:0005576 GO:0005581 GO:0005615 GO:0005886 GO:0006508 GO:0007186 GO:0009897 GO:0030246 GO:0032757 GO:0033691 GO:0034394 GO:0034774 GO:0038187 GO:0043654 GO:0046597 GO:0046872 GO:0062023 GO:0097367 GO:1903028 GO:1904813 GO:1905370
GL_000487	Galectin-2	P05162	Gal	Homo sapiens	9606	T cell homeostasis carbohydrate binding cell-cell adhesion galactoside binding galectin complex positive regulation of apoptotic process positive regulation of inflammatory response	GO:0016936 GO:0030246 GO:0043029 GO:0043065 GO:0050729 GO:0098609 GO:1990724
GL_001691	Lysosomal alpha-glucosidase	P10253		Homo sapiens	9606	alpha-1,4-glucosidase activity alpha-glucosidase activity aorta development autolysosome lumen azurophil granule membrane carbohydrate binding cardiac muscle contraction diaphragm contraction extracellular exosome ficolin-1-rich granule membrane glucose metabolic process glycogen catabolic process glycophagy heart morphogenesis intracellular membrane-bounded organelle locomotory behavior lysosomal lumen lysosomal membrane lysosome lysosome organization maltose alpha-glucosidase activity maltose metabolic process membrane muscle cell cellular homeostasis neuromuscular process controlling balance neuromuscular process controlling posture plasma membrane regulation of the force of heart contraction sucrose metabolic process tertiary granule membrane tissue development vacuolar sequestering	GO:0000023 GO:0002026 GO:0002086 GO:0003007 GO:0004558 GO:0005764 GO:0005765 GO:0005886 GO:0005980 GO:0005985 GO:0006006 GO:0007040 GO:0007626 GO:0009888 GO:0016020 GO:0030246 GO:0032450 GO:0035577 GO:0035904 GO:0043181 GO:0043202 GO:0043231 GO:0046716 GO:0050884 GO:0050885 GO:0060048 GO:0061723 GO:0070062 GO:0070821 GO:0090599 GO:0101003 GO:0120282
GL_000639	L-selectin	P14151		Homo sapiens	9606	calcium ion binding calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules carbohydrate binding cell adhesion external side of plasma membrane extracellular space glycosphingolipid binding heparin binding heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules leukocyte cell-cell adhesion leukocyte tethering or rolling oligosaccharide binding plasma membrane protease binding response to cytokine secretory granule membrane sialic acid binding	GO:0002020 GO:0005509 GO:0005615 GO:0005886 GO:0007155 GO:0007157 GO:0007159 GO:0008201 GO:0009897 GO:0016339 GO:0030246 GO:0030667 GO:0033691 GO:0034097 GO:0043208 GO:0050901 GO:0070492
GL_002375	Coxsackievirus and adenovirus receptor	P78310		Homo sapiens	9606	AV node cell to bundle of His cell communication AV node cell-bundle of His cell adhesion involved in cell communication PDZ domain binding acrosomal vesicle actin cytoskeleton organization adherens junction apicolateral plasma membrane basolateral plasma membrane beta-catenin binding bicellular tight junction cardiac muscle cell development cell adhesion molecule binding cell adhesive protein binding involved in AV node cell-bundle of His cell communication cell body cell junction cell-cell junction cell-cell junction organization connexin binding cytoplasm defense response to virus epithelial structure maintenance extracellular region extracellular space filopodium gamma-delta T cell activation germ cell migration growth cone heart development heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules homotypic cell-cell adhesion identical protein binding integrin binding intercalated disc membrane raft mitochondrion organization neuromuscular junction neuron projection neutrophil chemotaxis nucleoplasm plasma membrane protein-containing complex regulation of AV node cell action potential signaling receptor binding transepithelial transport virus receptor activity	GO:0001618 GO:0001669 GO:0005102 GO:0005178 GO:0005576 GO:0005615 GO:0005654 GO:0005737 GO:0005886 GO:0005911 GO:0005912 GO:0005923 GO:0007005 GO:0007157 GO:0007507 GO:0008013 GO:0008354 GO:0010669 GO:0014704 GO:0016323 GO:0016327 GO:0030036 GO:0030054 GO:0030165 GO:0030175 GO:0030426 GO:0030593 GO:0031594 GO:0032991 GO:0034109 GO:0042802 GO:0043005 GO:0044297 GO:0045121 GO:0045216 GO:0046629 GO:0050839 GO:0051607 GO:0055013 GO:0070633 GO:0071253 GO:0086067 GO:0086072 GO:0086082 GO:0098904
GL_000330	Complement component C1q receptor	Q9NPY3		Homo sapiens	9606	calcium ion binding carbohydrate binding cell surface cell-cell adhesion complement component C1q complex binding ficolin-1-rich granule membrane macrophage activation phagocytosis plasma membrane secretory granule membrane signaling receptor activity specific granule membrane tertiary granule membrane	GO:0001849 GO:0005509 GO:0005886 GO:0006909 GO:0009986 GO:0030246 GO:0030667 GO:0035579 GO:0038023 GO:0042116 GO:0070821 GO:0098609 GO:0101003
GL_000900	Polypeptide N-acetylgalactosaminyltransferase 14	Q96FL9		Homo sapiens	9606	Golgi apparatus Golgi membrane O-glycan processing carbohydrate binding metal ion binding polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation	GO:0000139 GO:0004653 GO:0005794 GO:0006493 GO:0016266 GO:0030246 GO:0046872
GL_001986	Asialoglycoprotein receptor 2	P07307		Homo sapiens	9606	asialoglycoprotein receptor activity cell surface receptor signaling pathway endoplasmic reticulum quality control compartment external side of plasma membrane fucose binding mannose binding perinuclear region of cytoplasm plasma membrane	GO:0004873 GO:0005537 GO:0005886 GO:0007166 GO:0009897 GO:0042806 GO:0044322 GO:0048471