GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	UniProt ID	Species	Taxonomy ID ▼	GO Labels	GO IDs
GL_000511	Galectin-8	Q9JL15	Mus musculus	10090	T cell costimulation carbohydrate binding cellular response to virus cytoplasm cytoplasmic vesicle cytosol integrin binding lymphatic endothelial cell migration plasma cell differentiation xenophagy	GO:0002317 GO:0005178 GO:0005737 GO:0005829 GO:0030246 GO:0031295 GO:0031410 GO:0098586 GO:0098792 GO:1904977
GL_002009	Ficolin-2	O70497	Mus musculus	10090	G protein-coupled receptor binding G protein-coupled receptor signaling pathway antigen binding calcium-dependent protein binding carbohydrate derivative binding cell surface pattern recognition receptor signaling pathway collagen trimer collagen-containing extracellular matrix complement activation, lectin pathway extracellular space identical protein binding mannan binding metal ion binding negative regulation of viral entry into host cell pattern recognition receptor activity plasma membrane positive regulation of interleukin-8 production positive regulation of opsonization protein localization to cell surface proteoglycan binding proteolysis recognition of apoptotic cell serine-type endopeptidase complex sialic acid binding signaling receptor binding	GO:0001664 GO:0001867 GO:0002752 GO:0003823 GO:0005102 GO:0005581 GO:0005615 GO:0005886 GO:0006508 GO:0007186 GO:0032757 GO:0033691 GO:0034394 GO:0038187 GO:0042802 GO:0043394 GO:0043654 GO:0046597 GO:0046872 GO:0048306 GO:0062023 GO:0097367 GO:1903028 GO:1905370 GO:2001065
GL_001008	Proteoglycan 3	Q9JL95	Mus musculus	10090	basophil activation carbohydrate binding histamine biosynthetic process immune response leukotriene biosynthetic process negative regulation of translation neutrophil activation positive regulation of interleukin-8 production superoxide anion generation	GO:0001694 GO:0006955 GO:0017148 GO:0019370 GO:0030246 GO:0032757 GO:0042119 GO:0042554 GO:0045575
GL_000200	C-type lectin domain family 9 member A	Q8BRU4	Mus musculus	10090	carbohydrate binding cell surface membrane positive regulation of cytokine production receptor-mediated endocytosis	GO:0001819 GO:0006898 GO:0009986 GO:0016020 GO:0030246
GL_000494	Galectin-3	P16110	Mus musculus	10090	Fc-gamma receptor I complex binding IgE binding RNA splicing advanced glycation end-product receptor activity antimicrobial humoral immune response mediated by antimicrobial peptide carbohydrate binding cell differentiation cell surface chemoattractant activity collagen-containing extracellular matrix cornified envelope cytoplasm cytosol disaccharide binding eosinophil chemotaxis external side of plasma membrane extracellular matrix extracellular matrix organization extracellular region extracellular space glial cell projection immunological synapse innate immune response killing of cells of another organism laminin binding mRNA processing macrophage chemotaxis mitochondrial inner membrane molecular condensate scaffold activity monocyte chemotaxis mononuclear cell migration monosaccharide binding negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell negative regulation of T cell receptor signaling pathway negative regulation of apoptotic process negative regulation of cell proliferation in bone marrow negative regulation of endocytosis negative regulation of extrinsic apoptotic signaling pathway negative regulation of immunological synapse formation neutrophil chemotaxis nucleoplasm nucleus oligosaccharide binding positive chemotaxis positive regulation of angiogenesis positive regulation of calcium ion import positive regulation of cell population proliferation positive regulation of mononuclear cell migration positive regulation of protein localization to plasma membrane positive regulation of protein-containing complex assembly positive regulation of serotonin secretion protein phosphatase binding regulation of T cell apoptotic process regulation of T cell proliferation regulation of extrinsic apoptotic signaling pathway via death domain receptors skeletal system development spliceosomal complex	GO:0001501 GO:0001533 GO:0001772 GO:0002548 GO:0005576 GO:0005615 GO:0005634 GO:0005654 GO:0005681 GO:0005737 GO:0005743 GO:0005829 GO:0006397 GO:0008284 GO:0008380 GO:0009897 GO:0009986 GO:0014064 GO:0019863 GO:0019903 GO:0030154 GO:0030198 GO:0030246 GO:0030593 GO:0031012 GO:0031334 GO:0031640 GO:0034988 GO:0042056 GO:0042129 GO:0043066 GO:0043236 GO:0045087 GO:0045766 GO:0045806 GO:0048029 GO:0048030 GO:0048245 GO:0048246 GO:0050785 GO:0050860 GO:0050918 GO:0061844 GO:0062023 GO:0070232 GO:0070492 GO:0071674 GO:0071677 GO:0090280 GO:0097386 GO:0140693 GO:1902041 GO:1903078 GO:1903769 GO:2000521 GO:2001189 GO:2001237
GL_000138	C-type lectin domain family 1 member B	Q9JL99	Mus musculus	10090	carbohydrate binding cell surface cell surface receptor signaling pathway plasma membrane platelet formation signal transduction transmembrane signaling receptor activity	GO:0004888 GO:0005886 GO:0007165 GO:0007166 GO:0009986 GO:0030220 GO:0030246
GL_000635	Killer cell lectin-like receptor subfamily I member 2	Q5DT36	Mus musculus	10090	carbohydrate binding external side of plasma membrane plasma membrane positive regulation of natural killer cell mediated cytotoxicity stimulatory C-type lectin receptor signaling pathway transmembrane signaling receptor activity	GO:0002223 GO:0004888 GO:0005886 GO:0009897 GO:0030246 GO:0045954
GL_001632	Glucose-6-phosphate 1-dehydrogenase 2	P97324	Mus musculus	10090	NADP binding NADP metabolic process NADPH regeneration carbohydrate binding cellular response to oxidative stress centriolar satellite cholesterol biosynthetic process cytoplasm cytoplasmic side of plasma membrane cytosol erythrocyte maturation glucose 6-phosphate metabolic process glucose binding glucose metabolic process glucose-6-phosphate dehydrogenase activity glutathione metabolic process identical protein binding intracellular membrane-bounded organelle negative regulation of cell growth involved in cardiac muscle cell development negative regulation of protein glutathionylation negative regulation of reactive oxygen species metabolic process pentose biosynthetic process pentose-phosphate shunt pentose-phosphate shunt, oxidative branch positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel protein homodimerization activity regulation of neuron apoptotic process response to ethanol ribose phosphate biosynthetic process	GO:0004345 GO:0005536 GO:0005737 GO:0005829 GO:0006006 GO:0006098 GO:0006695 GO:0006739 GO:0006740 GO:0006749 GO:0009051 GO:0009898 GO:0010734 GO:0019322 GO:0030246 GO:0034451 GO:0034599 GO:0042802 GO:0042803 GO:0043231 GO:0043249 GO:0043523 GO:0045471 GO:0046390 GO:0050661 GO:0051156 GO:0061052 GO:1904879 GO:2000378
GL_000678	Layilin	Q8C351	Mus musculus	10090	carbohydrate binding cell surface hyaluronic acid binding membrane ruffle	GO:0001726 GO:0005540 GO:0009986 GO:0016020 GO:0030246
GL_001987	Asialoglycoprotein receptor 2	P24721	Mus musculus	10090	bone mineralization endocytosis endoplasmic reticulum quality control compartment external side of plasma membrane fucose binding glycoprotein metabolic process lipid homeostasis mannose binding perinuclear region of cytoplasm regulation of protein stability	GO:0005537 GO:0006897 GO:0009100 GO:0009897 GO:0030282 GO:0031647 GO:0042806 GO:0044322 GO:0048471 GO:0055088