GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	UniProt ID	Species	Taxonomy ID ▼	GO Labels	GO IDs
GL_000825	NKG2-D type II integral membrane protein	O54709	Mus musculus	10090	MHC class I protein binding MHC class Ib receptor activity adaptive immune response carbohydrate binding cell differentiation cell surface cellular response to lipopolysaccharide defense response to Gram-positive bacterium external side of plasma membrane identical protein binding kinase binding natural killer cell activation natural killer cell mediated cytotoxicity negative regulation of natural killer cell chemotaxis nitric oxide biosynthetic process plasma membrane positive regulation of apoptotic process positive regulation of myeloid dendritic cell activation positive regulation of natural killer cell mediated cytotoxicity positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target positive regulation of nitric oxide biosynthetic process positive regulation of type II interferon production signaling receptor activity stimulatory C-type lectin receptor signaling pathway	GO:0002223 GO:0002250 GO:0002860 GO:0005886 GO:0006809 GO:0009897 GO:0009986 GO:0019900 GO:0030101 GO:0030154 GO:0030246 GO:0030887 GO:0032394 GO:0032729 GO:0038023 GO:0042267 GO:0042288 GO:0042802 GO:0043065 GO:0045429 GO:0045954 GO:0050830 GO:0071222 GO:2000502
GL_000620	Killer cell lectin-like receptor subfamily B member 1C	P27814	Mus musculus	10090	carbohydrate binding cell surface external side of plasma membrane identical protein binding natural killer cell activation plasma membrane positive regulation of natural killer cell mediated cytotoxicity regulation of natural killer cell mediated cytotoxicity signaling receptor activity	GO:0005886 GO:0009897 GO:0009986 GO:0030101 GO:0030246 GO:0038023 GO:0042269 GO:0042802 GO:0045954
GL_000359	Early activation antigen CD69	P37217	Mus musculus	10090	calcium ion binding carbohydrate binding cell surface cellular response to xenobiotic stimulus external side of plasma membrane identical protein binding protein-containing complex	GO:0005509 GO:0009897 GO:0009986 GO:0030246 GO:0032991 GO:0042802 GO:0071466
GL_001468	ER membrane protein complex subunit 7	Q9EP72	Mus musculus	10090	EMC complex carbohydrate binding endoplasmic reticulum membrane membrane membrane insertase activity protein insertion into ER membrane by stop-transfer membrane-anchor sequence tail-anchored membrane protein insertion into ER membrane	GO:0005789 GO:0016020 GO:0030246 GO:0032977 GO:0045050 GO:0071816 GO:0072546
GL_000884	Polypeptide N-acetylgalactosaminyltransferase 1	O08912	Mus musculus	10090	Golgi apparatus Golgi cisterna membrane carbohydrate binding extracellular region manganese ion binding perinuclear region of cytoplasm polypeptide N-acetylgalactosaminyltransferase activity protein O-linked glycosylation protein O-linked glycosylation via serine protein O-linked glycosylation via threonine	GO:0004653 GO:0005576 GO:0005794 GO:0006493 GO:0018242 GO:0018243 GO:0030145 GO:0030246 GO:0032580 GO:0048471
GL_000374	F-box only protein 2	Q80UW2	Mus musculus	10090	SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process amyloid-beta binding carbohydrate binding cytoplasm cytosol denatured protein binding dendritic spine endoplasmic reticulum extrinsic component of postsynaptic membrane glutamatergic synapse glycoprotein catabolic process negative regulation of cell population proliferation protein ubiquitination regulation of protein catabolic process at postsynapse, modulating synaptic transmission regulation of protein ubiquitination ubiquitin-dependent ERAD pathway ubiquitin-dependent protein catabolic process	GO:0001540 GO:0005737 GO:0005783 GO:0005829 GO:0006511 GO:0006516 GO:0008285 GO:0016567 GO:0019005 GO:0030246 GO:0030433 GO:0031146 GO:0031249 GO:0031396 GO:0043197 GO:0098890 GO:0098978 GO:0099576
GL_001729	Neutral alpha-glucosidase C	Q8BVW0	Mus musculus	10090	N-glycan processing alpha-1,4-glucosidase activity carbohydrate binding glucose metabolic process maltose alpha-glucosidase activity	GO:0004558 GO:0006006 GO:0006491 GO:0030246 GO:0032450
GL_001112	Sialic acid-binding Ig-like lectin 10	Q80ZE3	Mus musculus	10090	SH2 domain binding adaptive immune response carbohydrate binding cell adhesion hematopoietic progenitor cell differentiation innate immune response negative regulation of calcium-mediated signaling negative regulation of immunoglobulin production negative regulation of inflammatory response to wounding phosphatase binding plasma membrane regulation of B cell proliferation regulation of immune response sialic acid binding	GO:0002244 GO:0002250 GO:0002638 GO:0005886 GO:0007155 GO:0019902 GO:0030246 GO:0030888 GO:0033691 GO:0042169 GO:0045087 GO:0050776 GO:0050849 GO:0106015
GL_002076	VIP36-like protein	P59481	Mus musculus	10090	COPII-coated ER to Golgi transport vesicle Golgi apparatus Golgi membrane endoplasmic reticulum membrane endoplasmic reticulum to Golgi vesicle-mediated transport endoplasmic reticulum-Golgi intermediate compartment mannose binding metal ion binding protein transport	GO:0000139 GO:0005537 GO:0005789 GO:0005793 GO:0005794 GO:0006888 GO:0015031 GO:0030134 GO:0046872
GL_001232	Alpha-mannosidase 2	P27046	Mus musculus	10090	Golgi apparatus Golgi medial cisterna Golgi membrane N-glycan processing alpha-mannosidase activity carbohydrate binding cis-Golgi network extracellular space hydrolase activity hydrolase activity, hydrolyzing N-glycosyl compounds identical protein binding in utero embryonic development liver development lung alveolus development mannose metabolic process mannosidase activity mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity metal ion binding mitochondrion organization positive regulation of neurogenesis protein glycosylation protein homodimerization activity respiratory gaseous exchange by respiratory system retina morphogenesis in camera-type eye vacuole organization	GO:0000139 GO:0001701 GO:0001889 GO:0004559 GO:0004572 GO:0005615 GO:0005794 GO:0005797 GO:0005801 GO:0006013 GO:0006486 GO:0006491 GO:0007005 GO:0007033 GO:0007585 GO:0015923 GO:0016787 GO:0016799 GO:0030246 GO:0042802 GO:0042803 GO:0046872 GO:0048286 GO:0050769 GO:0060042