GlyCosmos Portal

GlyCosmos Lectins

Protein entries annotated as carbohydrate-binding in UniProt. Glycosylation site information, along with glycan-binding patterns are also integrated where available.

Database	Last Updated
MCAW-DB	July 10, 2019
UniLectin	June 14, 2023
UniProt	February 16, 2024
Lectin Frontier DataBase (LfDB)	February 16, 2024
CarboGrove	June 14, 2023

GlyCosmos Lectin	Lectin Name	UniProt ID	Species	Taxonomy ID	GO Labels	GO IDs ▼
GL_000287	Calreticulin	Q4R6K8	Macaca fascicularis	9541	MHC class I peptide loading complex calcium ion binding carbohydrate binding cell surface cellular senescence complement component C1q complex binding cortical granule cytolytic granule cytosol extracellular space integrin binding mRNA binding negative regulation of intracellular steroid hormone receptor signaling pathway negative regulation of neuron differentiation negative regulation of retinoic acid receptor signaling pathway negative regulation of transcription by RNA polymerase II negative regulation of translation negative regulation of trophoblast cell migration nuclear androgen receptor binding nuclear envelope nuclear export signal receptor activity perinuclear region of cytoplasm polysome positive regulation of cell cycle positive regulation of cell population proliferation positive regulation of dendritic cell chemotaxis positive regulation of endothelial cell migration positive regulation of substrate adhesion-dependent cell spreading protein export from nucleus protein folding protein localization to nucleus protein stabilization sarcoplasmic reticulum lumen ubiquitin protein ligase binding unfolded protein binding	GO:0000122 GO:0001849 GO:0003729 GO:0005049 GO:0005178 GO:0005509 GO:0005615 GO:0005635 GO:0005829 GO:0005844 GO:0006457 GO:0006611 GO:0008284 GO:0009986 GO:0010595 GO:0017148 GO:0030246 GO:0031625 GO:0033018 GO:0033144 GO:0034504 GO:0042824 GO:0044194 GO:0045665 GO:0045787 GO:0048387 GO:0048471 GO:0050681 GO:0050821 GO:0051082 GO:0060473 GO:0090398 GO:1900026 GO:1901164 GO:2000510
GL_000262	Calreticulin	P28491	Sus scrofa	9823	MHC class I peptide loading complex calcium ion binding carbohydrate binding cellular senescence complement component C1q complex binding cortical actin cytoskeleton organization cortical granule cytolytic granule cytosol endoplasmic reticulum membrane endoplasmic reticulum quality control compartment external side of plasma membrane extracellular space integrin binding mRNA binding negative regulation of intracellular steroid hormone receptor signaling pathway negative regulation of neuron differentiation negative regulation of retinoic acid receptor signaling pathway negative regulation of transcription by RNA polymerase II negative regulation of translation negative regulation of trophoblast cell migration nuclear androgen receptor binding nuclear envelope nuclear export signal receptor activity peptide antigen assembly with MHC class I protein complex perinuclear region of cytoplasm polysome positive regulation of cell cycle positive regulation of cell population proliferation positive regulation of dendritic cell chemotaxis positive regulation of endothelial cell migration positive regulation of gene expression positive regulation of non-canonical NF-kappaB signal transduction positive regulation of phagocytosis positive regulation of substrate adhesion-dependent cell spreading protein export from nucleus protein folding protein localization to nucleus protein stabilization regulation of meiotic nuclear division sarcoplasmic reticulum lumen ubiquitin protein ligase binding ubiquitin-dependent ERAD pathway unfolded protein binding	GO:0000122 GO:0001849 GO:0002502 GO:0003729 GO:0005049 GO:0005178 GO:0005509 GO:0005615 GO:0005635 GO:0005789 GO:0005829 GO:0005844 GO:0006457 GO:0006611 GO:0008284 GO:0009897 GO:0010595 GO:0010628 GO:0017148 GO:0030246 GO:0030433 GO:0030866 GO:0031625 GO:0033018 GO:0033144 GO:0034504 GO:0040020 GO:0042824 GO:0044194 GO:0044322 GO:0045665 GO:0045787 GO:0048387 GO:0048471 GO:0050681 GO:0050766 GO:0050821 GO:0051082 GO:0060473 GO:0090398 GO:1900026 GO:1901164 GO:1901224 GO:2000510
GL_000269	Calreticulin	P18418	Rattus norvegicus	10116	MHC class I peptide loading complex acrosomal vesicle calcium ion binding carbohydrate binding cardiac muscle cell differentiation cell surface cellular response to electrical stimulus cellular response to lithium ion cellular response to organic substance cellular response to virus cellular senescence collagen-containing extracellular matrix complement component C1q complex binding cortical actin cytoskeleton organization cortical granule cytolytic granule cytoplasm cytosol endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum quality control compartment external side of plasma membrane extracellular space hormone binding integrin binding iron ion binding mRNA binding membrane negative regulation of DNA-templated transcription negative regulation of intracellular steroid hormone receptor signaling pathway negative regulation of neuron differentiation negative regulation of retinoic acid receptor signaling pathway negative regulation of transcription by RNA polymerase II negative regulation of translation negative regulation of trophoblast cell migration nuclear androgen receptor binding nuclear envelope nuclear export signal receptor activity nucleus obsolete selective autophagy peptide antigen assembly with MHC class I protein complex peptide binding perinuclear region of cytoplasm polysome positive regulation of cell cycle positive regulation of cell population proliferation positive regulation of dendritic cell chemotaxis positive regulation of endothelial cell migration positive regulation of gene expression positive regulation of non-canonical NF-kappaB signal transduction positive regulation of phagocytosis positive regulation of substrate adhesion-dependent cell spreading protein export from nucleus protein folding protein localization to nucleus protein stabilization protein-containing complex regulation of meiotic nuclear division response to estradiol response to glycoside response to organic substance response to testosterone response to xenobiotic stimulus sarcoplasmic reticulum sarcoplasmic reticulum lumen smooth endoplasmic reticulum spermatogenesis ubiquitin protein ligase binding ubiquitin-dependent ERAD pathway unfolded protein binding	GO:0000122 GO:0001669 GO:0001849 GO:0002502 GO:0003729 GO:0005049 GO:0005178 GO:0005506 GO:0005509 GO:0005615 GO:0005634 GO:0005635 GO:0005737 GO:0005783 GO:0005788 GO:0005789 GO:0005790 GO:0005829 GO:0005844 GO:0006457 GO:0006611 GO:0007283 GO:0008284 GO:0009410 GO:0009897 GO:0009986 GO:0010033 GO:0010595 GO:0010628 GO:0016020 GO:0016529 GO:0017148 GO:0030246 GO:0030433 GO:0030866 GO:0031625 GO:0032355 GO:0032991 GO:0033018 GO:0033144 GO:0033574 GO:0034504 GO:0040020 GO:0042277 GO:0042562 GO:0042824 GO:0044194 GO:0044322 GO:0045665 GO:0045787 GO:0045892 GO:0048387 GO:0048471 GO:0050681 GO:0050766 GO:0050821 GO:0051082 GO:0055007 GO:0060473 GO:0061912 GO:0062023 GO:0071257 GO:0071285 GO:0071310 GO:0090398 GO:0098586 GO:1900026 GO:1901164 GO:1901224 GO:1903416 GO:2000510
GL_000271	Calreticulin	P14211	Mus musculus	10090	MHC class I peptide loading complex acrosomal vesicle calcium ion binding carbohydrate binding cardiac muscle cell differentiation cell surface cellular response to electrical stimulus cellular response to lithium ion cellular response to organic substance cellular response to virus cellular senescence collagen-containing extracellular matrix complement component C1q complex binding cortical actin cytoskeleton organization cortical granule cytolytic granule cytoplasm cytosol endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum quality control compartment external side of plasma membrane extracellular region extracellular space hormone binding integrin binding iron ion binding mRNA binding membrane negative regulation of DNA-templated transcription negative regulation of intracellular steroid hormone receptor signaling pathway negative regulation of neuron differentiation negative regulation of retinoic acid receptor signaling pathway negative regulation of transcription by RNA polymerase II negative regulation of translation negative regulation of trophoblast cell migration nuclear androgen receptor binding nuclear envelope nuclear export signal receptor activity nucleus obsolete selective autophagy peptide antigen assembly with MHC class I protein complex peptide binding perinuclear region of cytoplasm phagocytic vesicle polysome positive regulation of cell cycle positive regulation of cell population proliferation positive regulation of dendritic cell chemotaxis positive regulation of endothelial cell migration positive regulation of gene expression positive regulation of non-canonical NF-kappaB signal transduction positive regulation of phagocytosis positive regulation of substrate adhesion-dependent cell spreading protein export from nucleus protein folding protein localization to nucleus protein stabilization protein-containing complex regulation of meiotic nuclear division response to estradiol response to glycoside response to testosterone response to xenobiotic stimulus sarcoplasmic reticulum sarcoplasmic reticulum lumen smooth endoplasmic reticulum spermatogenesis ubiquitin protein ligase binding ubiquitin-dependent ERAD pathway unfolded protein binding	GO:0000122 GO:0001669 GO:0001849 GO:0002502 GO:0003729 GO:0005049 GO:0005178 GO:0005506 GO:0005509 GO:0005576 GO:0005615 GO:0005634 GO:0005635 GO:0005737 GO:0005783 GO:0005788 GO:0005789 GO:0005790 GO:0005829 GO:0005844 GO:0006457 GO:0006611 GO:0007283 GO:0008284 GO:0009410 GO:0009897 GO:0009986 GO:0010595 GO:0010628 GO:0016020 GO:0016529 GO:0017148 GO:0030246 GO:0030433 GO:0030866 GO:0031625 GO:0032355 GO:0032991 GO:0033018 GO:0033144 GO:0033574 GO:0034504 GO:0040020 GO:0042277 GO:0042562 GO:0042824 GO:0044194 GO:0044322 GO:0045335 GO:0045665 GO:0045787 GO:0045892 GO:0048387 GO:0048471 GO:0050681 GO:0050766 GO:0050821 GO:0051082 GO:0055007 GO:0060473 GO:0061912 GO:0062023 GO:0071257 GO:0071285 GO:0071310 GO:0090398 GO:0098586 GO:1900026 GO:1901164 GO:1901224 GO:1903416 GO:2000510
GL_000272	Calreticulin	P27797	Homo sapiens	9606	DNA binding MHC class I peptide loading complex RNA binding acrosomal vesicle calcium ion binding carbohydrate binding cardiac muscle cell differentiation cell surface cellular response to electrical stimulus cellular response to lithium ion cellular response to virus cellular senescence collagen-containing extracellular matrix complement component C1q complex binding cortical actin cytoskeleton organization cortical granule cytolytic granule cytoplasm cytosol endocytic vesicle lumen endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum quality control compartment endoplasmic reticulum-Golgi intermediate compartment membrane external side of plasma membrane extracellular exosome extracellular region extracellular space focal adhesion glucocorticoid receptor signaling pathway hormone binding integrin binding intracellular calcium ion homeostasis iron ion binding lumenal side of endoplasmic reticulum membrane mRNA binding membrane negative regulation of DNA-templated transcription negative regulation of intracellular steroid hormone receptor signaling pathway negative regulation of neuron differentiation negative regulation of retinoic acid receptor signaling pathway negative regulation of transcription by RNA polymerase II negative regulation of translation negative regulation of trophoblast cell migration nuclear androgen receptor binding nuclear envelope nuclear export signal receptor activity nucleus obsolete selective autophagy peptide antigen assembly with MHC class I protein complex peptide binding perinuclear region of cytoplasm phagocytic vesicle membrane polysome positive regulation of cell cycle positive regulation of cell population proliferation positive regulation of dendritic cell chemotaxis positive regulation of endothelial cell migration positive regulation of gene expression positive regulation of non-canonical NF-kappaB signal transduction positive regulation of phagocytosis positive regulation of substrate adhesion-dependent cell spreading protein export from nucleus protein folding protein folding chaperone protein folding in endoplasmic reticulum protein localization to nucleus protein maturation by protein folding protein stabilization protein-folding chaperone binding regulation of DNA-templated transcription regulation of apoptotic process regulation of meiotic nuclear division response to estradiol response to glycoside response to testosterone response to xenobiotic stimulus sarcoplasmic reticulum lumen sequestering of calcium ion smooth endoplasmic reticulum spermatogenesis ubiquitin protein ligase binding ubiquitin-dependent ERAD pathway unfolded protein binding zinc ion binding	GO:0000122 GO:0001669 GO:0001849 GO:0002502 GO:0003677 GO:0003723 GO:0003729 GO:0005049 GO:0005178 GO:0005506 GO:0005509 GO:0005576 GO:0005615 GO:0005634 GO:0005635 GO:0005737 GO:0005783 GO:0005788 GO:0005789 GO:0005790 GO:0005829 GO:0005844 GO:0005925 GO:0006355 GO:0006457 GO:0006611 GO:0006874 GO:0007283 GO:0008270 GO:0008284 GO:0009410 GO:0009897 GO:0009986 GO:0010595 GO:0010628 GO:0016020 GO:0017148 GO:0022417 GO:0030246 GO:0030433 GO:0030670 GO:0030866 GO:0031625 GO:0032355 GO:0033018 GO:0033116 GO:0033144 GO:0033574 GO:0034504 GO:0034975 GO:0040020 GO:0042277 GO:0042562 GO:0042824 GO:0042921 GO:0042981 GO:0044183 GO:0044194 GO:0044322 GO:0045665 GO:0045787 GO:0045892 GO:0048387 GO:0048471 GO:0050681 GO:0050766 GO:0050821 GO:0051082 GO:0051087 GO:0051208 GO:0055007 GO:0060473 GO:0061912 GO:0062023 GO:0070062 GO:0071257 GO:0071285 GO:0071682 GO:0090398 GO:0098553 GO:0098586 GO:1900026 GO:1901164 GO:1901224 GO:1903416 GO:2000510
GL_001477	F-box only protein 6	Q9NRD1	Homo sapiens	9606	DNA damage checkpoint signaling DNA repair SCF ubiquitin ligase complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process carbohydrate binding cytoplasm cytosol endoplasmic reticulum quality control compartment glycoprotein catabolic process protein ubiquitination proteolysis response to unfolded protein ubiquitin protein ligase activity ubiquitin-dependent ERAD pathway	GO:0000077 GO:0005737 GO:0005829 GO:0006281 GO:0006508 GO:0006516 GO:0006986 GO:0016567 GO:0019005 GO:0030246 GO:0030433 GO:0031146 GO:0044322 GO:0061630
GL_001679	Laforin	O95278	Homo sapiens	9606	L-glutamate transmembrane transport Wnt signaling pathway autophagosome assembly calcium ion transport carbohydrate binding carbohydrate phosphatase activity carbohydrate phosphorylation cytoplasm cytoplasmic side of rough endoplasmic reticulum membrane cytosol dendrite dephosphorylation glial cell proliferation glycogen (starch) synthase activity glycogen binding glycogen biosynthetic process glycogen metabolic process habituation mitochondrion organization myosin phosphatase activity negative regulation of cell cycle negative regulation of dephosphorylation negative regulation of gene expression negative regulation of peptidyl-serine phosphorylation negative regulation of phosphatase activity nucleoplasm nucleus peptidyl-tyrosine dephosphorylation perikaryon phosphatase activity plasma membrane positive regulation of macroautophagy proteasome-mediated ubiquitin-dependent protein catabolic process protein dephosphorylation protein dimerization activity protein homodimerization activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activity protein tyrosine/serine/threonine phosphatase activity regulation of cell growth regulation of proteasomal protein catabolic process regulation of protein import into nucleus regulation of protein localization to plasma membrane regulation of protein ubiquitination starch binding	GO:0000045 GO:0001558 GO:0004373 GO:0004722 GO:0004725 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005886 GO:0005977 GO:0005978 GO:0006470 GO:0006816 GO:0007005 GO:0008138 GO:0010629 GO:0010923 GO:0014009 GO:0015813 GO:0016055 GO:0016239 GO:0016311 GO:0016791 GO:0017018 GO:0019203 GO:0030246 GO:0030425 GO:0031396 GO:0033137 GO:0035305 GO:0035335 GO:0042306 GO:0042803 GO:0043161 GO:0043204 GO:0045786 GO:0046835 GO:0046959 GO:0046983 GO:0061136 GO:0098556 GO:1903076 GO:2001069 GO:2001070
GL_001678	Laforin	Q91XQ2	Rattus norvegicus	10116	L-glutamate transmembrane transport Wnt signaling pathway autophagosome assembly autophagy calcium ion transport carbohydrate binding carbohydrate phosphatase activity carbohydrate phosphorylation cytoplasm cytoplasmic side of endoplasmic reticulum membrane cytoplasmic side of rough endoplasmic reticulum membrane cytosol dendrite dephosphorylation glial cell proliferation glycogen (starch) synthase activity glycogen binding glycogen biosynthetic process glycogen metabolic process habituation identical protein binding macromolecule metabolic process mitochondrion organization myosin phosphatase activity negative regulation of TOR signaling negative regulation of cell cycle negative regulation of gene expression negative regulation of peptidyl-serine phosphorylation nervous system development nucleus perikaryon phosphatase activity phosphoprotein phosphatase activity plasma membrane polysaccharide binding positive regulation of macroautophagy proteasome-mediated ubiquitin-dependent protein catabolic process protein homodimerization activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activity protein tyrosine/serine/threonine phosphatase activity regulation of cell growth regulation of gene expression regulation of phosphorylation regulation of proteasomal protein catabolic process regulation of protein import into nucleus regulation of protein localization to plasma membrane regulation of protein phosphorylation regulation of protein ubiquitination starch binding	GO:0000045 GO:0001558 GO:0001932 GO:0004373 GO:0004721 GO:0004722 GO:0004725 GO:0005634 GO:0005737 GO:0005829 GO:0005886 GO:0005977 GO:0005978 GO:0006816 GO:0006914 GO:0007005 GO:0007399 GO:0008138 GO:0010468 GO:0010629 GO:0014009 GO:0015813 GO:0016055 GO:0016239 GO:0016311 GO:0016791 GO:0017018 GO:0019203 GO:0030246 GO:0030247 GO:0030425 GO:0031396 GO:0032007 GO:0033137 GO:0042306 GO:0042325 GO:0042802 GO:0042803 GO:0043161 GO:0043170 GO:0043204 GO:0045786 GO:0046835 GO:0046959 GO:0061136 GO:0098554 GO:0098556 GO:1903076 GO:2001069 GO:2001070
GL_001680	Laforin	Q9WUA5	Mus musculus	10090	L-glutamate transmembrane transport Wnt signaling pathway autophagosome assembly autophagy calcium ion transport carbohydrate binding carbohydrate phosphatase activity carbohydrate phosphorylation cytoplasm cytoplasmic side of endoplasmic reticulum membrane cytoplasmic side of rough endoplasmic reticulum membrane cytosol dendrite dephosphorylation glial cell proliferation glycogen (starch) synthase activity glycogen binding glycogen biosynthetic process glycogen metabolic process habituation identical protein binding macromolecule metabolic process mitochondrion organization myosin phosphatase activity negative regulation of TOR signaling negative regulation of cell cycle negative regulation of dephosphorylation negative regulation of gene expression negative regulation of peptidyl-serine phosphorylation nervous system development nucleoplasm nucleus perikaryon phosphatase activity phosphoprotein phosphatase activity plasma membrane polysaccharide binding polysome positive regulation of macroautophagy proteasome-mediated ubiquitin-dependent protein catabolic process protein dimerization activity protein homodimerization activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activity protein tyrosine/serine/threonine phosphatase activity regulation of cell growth regulation of gene expression regulation of phosphorylation regulation of proteasomal protein catabolic process regulation of protein import into nucleus regulation of protein localization to plasma membrane regulation of protein phosphorylation regulation of protein ubiquitination starch binding	GO:0000045 GO:0001558 GO:0001932 GO:0004373 GO:0004721 GO:0004722 GO:0004725 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005844 GO:0005886 GO:0005977 GO:0005978 GO:0006816 GO:0006914 GO:0007005 GO:0007399 GO:0008138 GO:0010468 GO:0010629 GO:0014009 GO:0015813 GO:0016055 GO:0016239 GO:0016311 GO:0016791 GO:0017018 GO:0019203 GO:0030246 GO:0030247 GO:0030425 GO:0031396 GO:0032007 GO:0033137 GO:0035305 GO:0042306 GO:0042325 GO:0042802 GO:0042803 GO:0043161 GO:0043170 GO:0043204 GO:0045786 GO:0046835 GO:0046959 GO:0046983 GO:0061136 GO:0098554 GO:0098556 GO:1903076 GO:2001069 GO:2001070
GL_001711	Maltose phosphorylase	E6ENP7	Enterococcus faecalis TX4000	749493	carbohydrate binding maltose catabolic process maltose phosphorylase activity	GO:0000025 GO:0030246 GO:0050082